Clinical and Molecular Hepatology, Год журнала: 2023, Номер 29(4), С. 1050 - 1051
Опубликована: Авг. 29, 2023
Язык: Английский
Egyptian Liver Journal, Год журнала: 2024, Номер 14(1)
Опубликована: Авг. 2, 2024
Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases, and it characterized by a series diseases that can lead to severe disease. Although no therapeutic drug has been approved as an effective therapy for NAFLD date, dietary changes physical activity are thought be cornerstone management. For this reason, some articles available analyze studies done so far using various modifications intermittent fasting (IF) among animals patients with NAFLD. Data from preclinical clinical trials suggested IF positively impacts inflammatory metabolic markers in both humans. Inflammation oxidative stress major risk factors involved pathogenesis shown have positive benefits alleviating disorders, promoting browning white tissue, resetting circadian rhythm, activating autophagy cells. This review intended provide detailed synopsis protocols, potential mechanisms action, supporting evidence We will highlight what currently known about approaches treatments populations mechanism insight animal studies, safety concerns certain patient groups. Graphical The protocols various. humans animals. nonalcoholic
Язык: Английский
Процитировано
4
Antioxidants, Год журнала: 2025, Номер 14(1), С. 99 - 99
Опубликована: Янв. 16, 2025
Cellular senescence is a state of permanent cell cycle arrest accompanied by metabolic activity and characteristic phenotypic changes. This process crucial for developing age-related diseases, where excessive calorie intake accelerates dysfunction aging. Overnutrition disturbs key pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target rapamycin (mTOR), AMP-activated protein kinase. The dysregulation these pathways contributes to insulin resistance, impaired autophagy, exacerbated oxidative stress, mitochondrial dysfunction, further enhancing cellular systemic derangements. On other hand, dysfunctional endothelial cells adipocytes contribute inflammation, reduced nitric oxide production, altered lipid metabolism. Numerous factors, extracellular vesicles, mediate pathological communication between vascular system adipose tissue, amplifying imbalances. Meanwhile, caloric restriction (CR) emerges as potent intervention counteract overnutrition effects, improve function, reduce restore balance. CR modulates such IIS, mTOR, sirtuins, glucose metabolism, reducing promoting autophagy. can extend health span mitigate diseases delaying improving healthy endothelial-adipocyte interactions. review highlights crosstalk adipocytes, emphasizing potential in counteracting overnutrition-induced restoring homeostasis.
Язык: Английский
Процитировано
0
Clinical and Molecular Hepatology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 6, 2025
Lifestyle and dietary intake play a pivotal role in development of metabolic dysfunction-associated fatty liver disease(MAFLD). We performed this cross-sectional study to evaluate the association between lifestyle insulinemic potential odds MAFLD overweight obese children adolescents. The diet was assessed by computing scores empirical index for hyperinsulinemia(EDIH), hyperinsulinemia(ELIH), insulin resistance(EDIR), resistance(ELIR). diagnosed according consensus definitions. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated logistic regression. A total 334 (49.1% boys) with mean ± SD age BMI-for-age-Z-score 9.3 1.8 2.55 0.69, respectively, enrolled. After adjusting all confounders, participants highest quartile ELIH score had greater developing (OR:3.50;95%CI:1.49–8.22) compared those lowest quartile. This remained significant among boys pubertal ones. However, no EDIH, EDIR, or ELIR found. Our suggests that collective intake, BMI, physical activity is associated increased MAFLD.
Язык: Английский
Процитировано
0
Healthcare, Год журнала: 2025, Номер 13(4), С. 351 - 351
Опубликована: Фев. 7, 2025
Background/Objectives: Fatty liver disease (FLD), particularly non-alcoholic fatty (NAFLD), is a growing global health concern that underscores the need for effective dietary management strategies. With over 25% of patients seeking advice through platforms like YouTube, quality and reliability this information remain critical. However, disparity in educational value engagement metrics between professional non-professional content remains underexplored. This study evaluates YouTube's role disseminating FLD management, focusing on reliability, metrics, videos. Methods: cross-sectional systematically analyzed 183 YouTube videos advice. Videos were selected based relevance, English language, non-promotional content. Scoring systems, including DISCERN, Global Quality Score (GQS), Video Information Index (VIQI), employed to assess quality, value. Engagement such as views, likes, dislikes, interaction rates across uploader categories, healthcare professionals, patients, undefined sources. Results: uploaded by professionals demonstrated significantly higher DISCERN scores (4.2 ± 0.8) GQS ratings (4.1 0.6) compared patient-generated (DISCERN: 2.8 0.9; GQS: 3.0 0.7). achieved rates, with median views reaching 340,000 (IQR: 15,000-1,000,000) 450,050 23,000-1,800,000) Nutritional recommendations spanned diverse approaches, low-carb diets, Mediterranean guidance avoid processed foods sugars. A significant proportion lacked evidence-based content, among uploads. Conclusions: represents widely accessed but inconsistent source FLD. While exhibit value, achieves broader engagement, revealing critical gap trusted, accessible guidance. These findings highlight clinicians creators collaborate curating ensuring receive accurate, actionable managing
Язык: Английский
Процитировано
0
Foods, Год журнала: 2025, Номер 14(5), С. 888 - 888
Опубликована: Март 5, 2025
The growing consumption of processed foods, including meat-based and plant-based burgers (PBM), raises concerns about their long-term health effects. While PBM are marketed as healthier alternatives, biochemical histological impacts remain unclear. This study investigates the effects chronic burger on metabolic organ health, considering sex differences. Thirty-six Wistar rats (18 males 18 females) were divided into three groups: control (standard chow), meat burger-fed, burger-fed. Improved chow was prepared using lyophilized powder. Over eight weeks, food intake, weight gain, efficiency ratio (FER) monitored. Serum markers, AST, ALT, urea, creatinine, lipid profile (TG, CHOL, HDL, LDL), leptin, analyzed, alongside histopathological evaluation liver, kidneys, heart. PBM-fed exhibited significantly higher FER than group (p < 0.05). AST ALT levels slightly elevated in meat-fed rats, while had increased urea levels. Triglyceride group, but cholesterol did not differ significantly. leptin both experimental groups, suggesting resistance. Histological findings showed mild hepatic inflammation microvacuolar changes, with minor cardiac fibrosis. These highlight need for further research PBM's
Язык: Английский
Процитировано
0
Terapevt (General Physician), Год журнала: 2025, Номер 3, С. 37 - 61
Опубликована: Март 25, 2025
Non-alcoholic fatty liver disease is a chronic progressive with variable outcome. Treatment of non-alcoholic aimed at eliminating risk factors, improving metabolic status, and preventing progression. The mainstay therapy lifestyle modification, including nutrition physical activity. A personalized diet the elimination dietary factors subsequent organization rational play an important role. Pharmacotherapy for currently has no approved specific drugs, but some drugs are used «off-label» to reduce inflammation fibrosis or treat concomitant disorders. For example, metformin in presence type 2 diabetes mellitus prediabetes improve insulin sensitivity, although its effect on limited. Thiazolidinediones such as pioglitazone can steatosis patients metabolically associated disease, their use limited confirmed diagnosis. Vitamin E (α-tocopherol) may be useful non-diabetic NASH dose 800 IU/day, long-term requires caution due possible side effects. Statins (atorvastatin, rosu vastatin) widely control cholesterol levels prevent cardiovascular complica tions safe disease. Angiotensin II receptor antagonists (eg, losartan) have additional antifibrotic effect. New approaches treatment being actively studied. GLP-1 agonists (liraglutide, semaglutide) SGLT-2 inhibitors (dapagliflozin, empagliflozin), diabetes, show promising results reducing body weight steatosis. Drugs action, obeticholic acid, also
Язык: Английский
Процитировано
0
Molecular Diversity, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Процитировано
0
Food & Function, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Several meta-analyses have summarized the associations between dietary factors and risk of hepatocellular carcinoma (HCC).
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2023, Номер 15(10), С. 2394 - 2394
Опубликована: Май 19, 2023
Although previous epidemiological studies have been conducted to investigate the relationship between nut consumption and risk of nonalcoholic fatty liver disease (NAFLD), evidence remains inconclusive contentious. The aim our study was further conduct a meta-analysis observational explore latest influence on NAFLD. This included comprehensive search all articles published in PubMed Web Science online databases as April 2023. A total 11 were included, comprising 2 prospective cohort studies, 3 cross-sectional 7 case-control random effects model used evaluate nuts Results showed that odds ratio (OR) NAFLD 0.90 (95% CI: 0.81-0.99, p < 0.001) when comparing highest lowest intake, indicating significant negative correlation. Furthermore, subgroup analysis revealed protective effect more females (OR = 0.88; 95% 0.78-0.98, I2 76.2%). In summary, findings provide support for intake Further exploration association other dietary components is an important avenue future research.
Язык: Английский
Процитировано
10