Racing toward the future of chronic hepatitis B management: Achieving functional cure and enhancing hepatocellular carcinoma surveillance through precision medicine

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Hepatitis B virus (HBV) infection represents a significant global public health threat, often progressing to severe complications such as liver cirrhosis and hepatocellular carcinoma (HCC). Despite the World Health Organization’s 2030 challenge eliminate HBV, achieving functional cure remains major milestone in fight against disease. However, even with cure, risk of HCC persists, necessitating ongoing surveillance. Hopefully, advances technological innovations, artificial intelligence, establishment data platforms have enhanced both prediction surveillance strategies. This review examines recent advancements HBV therapies, models for chronic hepatitis (CHB) (such GOLDEN model) evaluating these new approaches, current state Furthermore, potential novel biomarkers is highlighted context precision medicine improve CHB assessment.

Язык: Английский

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The Associations of Serum Folate Forms with Metabolic Dysfunction-Associated Fatty Liver Disease and Liver Fibrosis: A Nationwide Cross-Sectional Study

Metabolites, Год журнала: 2025, Номер 15(6), С. 370 - 370

Опубликована: Июнь 5, 2025

Background: Accumulating evidence indicates a link between folate and metabolic dysfunction-associated fatty liver disease (MAFLD). Objectives: The aim of this study was to ascertain whether different serum forms are associated with newly defined MAFLD as well fibrosis in the US general population. Methods: This cross-sectional used data from 2017–2020 (March) cycle 2017–2018 National Health Nutrition Examination Survey (NHANES) US. Hepatic steatosis were evaluated by transient elastography, which employed controlled attenuation parameters stiffness measurements assessment indicators. Results: 7447 eligible individuals included. estimated prevalence 51.6% (95% confidence interval [CI]: 50.4–52.7%) 10.0% CI: 9.3–10.7%). After adjusting for confounding factors, every 1 nmol/L increase 5-methyltetrahydrofolate (5-mTHF), risk developing decreased 1% 1–2%, p < 0.001), 0–2%, = 0.005). There also significant differences indicators such alanine aminotransferase (ALT), gamma-glutamyl transaminase (GGT), C-reactive protein (CRP) group non-MAFLD (all values 0.001). Conclusions: suggests significantly 5-mTHF concentration.

Язык: Английский

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Changing the nomenclature from nonalcoholic fatty liver disease to metabolic dysfunction-associated fatty liver disease is more than a change in terminology

Clinical and Molecular Hepatology, Год журнала: 2023, Номер 29(2), С. 371 - 373

Опубликована: Март 14, 2023

Язык: Английский

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High prevalence of fatty liver and its association with metabolic syndrome among rural adults with chronic hepatitis C: Implications for primary healthcare

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 20, 2024

Abstract Background Chronic hepatitis C (CHC) virus infection is a global health concern that associated with significant liver-related morbidity and mortality. Owing to the inflammatory pathway, CHC can causefatty liver, liver cirrhosis, cancer cardiometabolic diseases, such as hypertension diabetes. Fatty metabolic disorders, cardiovascular diabetes, cancer. Hence, early detection of fatty through noninvasive screening in adults important primary healthcare settings. This study aimed explore prevalence its association syndrome amongrural CHC. Methods was series cohort studies related elimination burden around western coastal Yunlin County, Taiwan, between August 2018 July 2021. A cross-sectional conducted after RNA confirmation C- endemic area. gastrointestinal physician or radiologist assessed by ultrasonography. classified into four grades: normal, mild, moderate, severe. Three enzyme biomarkers were identified. According Taiwan national standard, defined based on presence three more five abnormal biomarkers, including increased waist circumference, elevated blood pressure, fasting glucose level, triglyceride low high-density lipoprotein cholesterol level. Results total 256 rural enrolled. The mean age participants 67.5 (standard deviation = 11.8) years, educational High (79%), central obesity (54.3%), pressure (55.5%),elevated (FBG) level (44.9%), (37.9%) observed.The results showed moderate severe significantly an risk circumference ( P < 0.001), 0.05), biomarker levels (all 0.05) adjusting for age, sex, Furthermore, greater (odds ratio 2.85, 95% confidence interval 1.66 4.92). Conclusions findings demonstrate high CHC, which obesity, syndrome, levels. Clinicians providers must encourage patients receive antiviral therapy combined weight loss management lifestyle modification, allowing general improvements their health.

Язык: Английский

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Functional cure of chronic hepatitis B encounters resmetirom

Clinical and Molecular Hepatology, Год журнала: 2024, Номер 30(3), С. 580 - 581

Опубликована: Апрель 30, 2024

Язык: Английский

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