Overcoming age: Slow anesthesia induction may prevent geriatric patients from developing burst suppression and help developing intraoperative EEG signatures of a younger brain DOI Creative Commons
David P. Obert, P. Sepúlveda,

V Adriazola

и другие.

Journal of Clinical Anesthesia, Год журнала: 2024, Номер 99, С. 111672 - 111672

Опубликована: Окт. 31, 2024

Язык: Английский

The effect of anesthesia on postoperative cognitive dysfunction in adults undergoing cataract surgery: a systematic review DOI Creative Commons

E Foroughi,

Etrusca Brogi, Francesco Forfori

и другие.

BMC Anesthesiology, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 23, 2025

We systematically reviewed the evidence on effect of anesthetic methods and drugs incidence postoperative cognitive dysfunction (POCD) after cataract surgery. The Web Science, PubMed, Scopus databases were searched for relevant English reports published from 2000 to August 2024. After full-text screening checking quality assessment each article using JBI checklist, 9 articles included in this study. explain how different modalities may affect POCD Our study aimed investigate relationship between various anesthesia people undergoing clinical trials with 1014 participants, which analyzed interventions. Four compared modality interventions five studies POCD. used measurement scales, including Mini-Mental State Examination, Neurobehavioral Rating Scale, Blessed Orientation-Memory-Concentration Test, Iowa Satisfaction Anesthesia scale, PALT, VF test. All that local topical found no statistically significant difference at postop days 1 7. General cause approximately twofold than anesthesia. Ketamine, Midazolam, or Dexmedetomidine seemed reduce complications control group‌‌. This systematic review investigates techniques available literature is far being conclusive further are needed reach any conclusions. It necessary adopt an appropriate method elderly high-risk patients, especially who have a history problems‌‌ elective surgery, surgery.‌

Язык: Английский

Процитировано

0

Sedation with midazolam in the NICU: implications on neurodevelopment DOI

Nghi M. Nguyen,

Gurudutt Pendyala

NeuroImmune Pharmacology and Therapeutics, Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Abstract The developing brain, particularly in premature infants, is highly susceptible to environmental and pharmacological influences. Premature neonates often require prolonged stays the NICU, where midazolam (MDZ), a benzodiazepine, commonly used as sedative, despite concerns raised by FDA 2016 regarding its potential neurological complications infants. Understanding long-term effects of MDZ on these vulnerable patients hindered ethical considerations limited research. This review emphasizes vulnerability infants sedation anesthesia outlines how early exposure can impact brain development at both molecular behavioral levels, drawing from clinical preclinical data. Additionally, we highlighted existing knowledge gaps suggested avenues for further research better comprehend enduring consequences neurodevelopment this population.

Язык: Английский

Процитировано

2

Overcoming age: Slow anesthesia induction may prevent geriatric patients from developing burst suppression and help developing intraoperative EEG signatures of a younger brain DOI Creative Commons
David P. Obert, P. Sepúlveda,

V Adriazola

и другие.

Journal of Clinical Anesthesia, Год журнала: 2024, Номер 99, С. 111672 - 111672

Опубликована: Окт. 31, 2024

Язык: Английский

Процитировано

1