The organ-specific modulation of malignant processes by opioids: a systematic review of cell culture studies DOI Creative Commons

Natalia Hefteh,

Olivia Welch,

Mahdi Sheikh

и другие.

British Journal of Cancer, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract Background The International Agency for Research on Cancer (IARC) monographs recently classified opium consumption as carcinogenic to humans in certain organs, raising concerns regarding the effects of pharmaceutical opioids. This systematic review (Open Science Framework osf.io/xyg9p) evaluated whether opioid exposure causes organ-specific modulation malignant processes cancer cell culture studies. Methods We identified all research articles evaluating tumour by opioids vitro through 28/02/2024. Data organ origin cells, activity, exposure, and outcomes (tumour growth, metastasis, clonogenicity) were extracted. Statistical analyses performed using Fisher’s exact tests multivariable logistic regression. Results anti-cancer outcome was most prevalent (57%) while only 11% experiments reported pro-cancer outcomes. A total 230 publications, comprising 1465 experiments, included. Low concentrations ( p = 0.0005), short durations 0.0035), organs where risk increases with use 0.002), associated reporting agonists. Conclusion findings support a positive association between growth cells from lung, bladder, larynx, pancreas, pharynx, stomach, or oesophagus further reveal duration concentration critical factors cultured cells.

Язык: Английский

The organ-specific modulation of malignant processes by opioids: a systematic review of cell culture studies DOI Creative Commons

Natalia Hefteh,

Olivia Welch,

Mahdi Sheikh

и другие.

British Journal of Cancer, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract Background The International Agency for Research on Cancer (IARC) monographs recently classified opium consumption as carcinogenic to humans in certain organs, raising concerns regarding the effects of pharmaceutical opioids. This systematic review (Open Science Framework osf.io/xyg9p) evaluated whether opioid exposure causes organ-specific modulation malignant processes cancer cell culture studies. Methods We identified all research articles evaluating tumour by opioids vitro through 28/02/2024. Data organ origin cells, activity, exposure, and outcomes (tumour growth, metastasis, clonogenicity) were extracted. Statistical analyses performed using Fisher’s exact tests multivariable logistic regression. Results anti-cancer outcome was most prevalent (57%) while only 11% experiments reported pro-cancer outcomes. A total 230 publications, comprising 1465 experiments, included. Low concentrations ( p = 0.0005), short durations 0.0035), organs where risk increases with use 0.002), associated reporting agonists. Conclusion findings support a positive association between growth cells from lung, bladder, larynx, pancreas, pharynx, stomach, or oesophagus further reveal duration concentration critical factors cultured cells.

Язык: Английский

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