Royal Society of Chemistry eBooks,
Год журнала:
2024,
Номер
unknown, С. 20 - 39
Опубликована: Ноя. 15, 2024
Implantation
of
biomaterials
into
the
human
body
is
important
for
biological
applications
and
medical
field.
The
issues
in
this
field
that
require
immediate
attention
are
extending
lifespan
biomaterial
implants,
decreasing
body’s
rejection
response,
lowering
risk
infection.
surface
can
be
modified
to
alter
their
initial
chemical,
biological,
physical
characteristics
while
also
enhancing
functionality
biomaterials.
practical
implications
methods
modification
surfaces
various
fields
have
been
reported
last
few
years
main
focus
chapter.
Film
coating
production,
covalent
transplantation,
self-assembled
monolayers,
plasma
alteration
examples
techniques.
First,
these
briefly
introduced.
A
brief
summary
discussed
then
shifts
how
biomaterials,
assessing
impact
alterations
on
cell
compatibility,
antibacterial
properties,
antifouling
hydrophobic
characteristics.
consequences
development
purposes
addressed
RSC Advances,
Год журнала:
2023,
Номер
13(30), С. 20495 - 20511
Опубликована: Янв. 1, 2023
Biomaterial
implantation
into
the
human
body
plays
a
key
role
in
medical
and
biological
field.
It
increases
life
expectancy,
reduces
rejection
reaction
risk
infections.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
157, С. 113998 - 113998
Опубликована: Ноя. 16, 2022
Cancer
immunotherapy
is
a
therapeutic
strategy
to
inhibit
tumor
growth
and
metastasis
by
intervening
in
the
immune
response
process.
Strategies
applied
cancer
mainly
include
blocking
checkpoints,
adoptive
transfer
of
engineered
cells,
cytokine
therapy,
vaccines,
oncolytic
virus
infection.
However,
many
factors,
such
as
off-target
side
effects,
immunosuppressive
cell
infiltration
and/or
upregulation
checkpoint
expression,
heterogeneity,
lack
antigen
presentation,
affect
effect
on
cancer.
To
improve
efficacy
targeted
reduce
over
past
two
decades,
nanoparticle
delivery
platforms
have
been
increasingly
used
immunotherapy.
nanoparticles
are
still
subject
biological
barriers
biodistribution
challenges,
which
limit
their
overall
clinical
potential.
This
has
prompted
series
overcome
specific
obstacles
accumulation
payloads
tumor-infiltrating
cells.
In
recent
years,
new
techniques
chemical
methods
employed
modify
or
functionalize
surfaces
nanoparticles.
review
discusses
progress
surface-engineered
inducing
responses
immunotherapy,
well
future
directions
for
development
next-generation
nanomedicines.
Membranes,
Год журнала:
2022,
Номер
12(12), С. 1244 - 1244
Опубликована: Дек. 8, 2022
Extracellular
vesicles
(EV)
are
membrane
surrounded
by
a
lipid
bilayer
and
include
microvesicles,
apoptotic
bodies,
exosomes,
exomeres.
Exosome-encapsulated
microRNAs
(miRNAs)
released
from
cancer
cells
involved
in
the
proliferation
metastasis
of
tumor
via
angiogenesis.
On
other
hand,
mesenchymal
stem
cell
(MSC)
therapy,
which
is
being
employed
regenerative
medicine
owing
to
ability
MSCs
differentiate
into
various
cells,
due
humoral
factors,
including
messenger
RNA
(mRNA),
miRNAs,
proteins,
lipids,
encapsulated
exosomes
derived
transplanted
cells.
New
treatments
that
advocate
cell-free
therapy
using
MSC-derived
will
significantly
improve
clinical
practice.
Therefore,
highly
purified
perform
their
original
functions
desirable.
In
this
review,
we
summarized
advances
purification,
modification,
application
EVs
as
novel
strategies
treat
some
diseases.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
This
study
introduces
a
comprehensive
approach
to
enhancing
SiNx
nanofilters
for
exosome
isolation
from
bovine
milk
using
the
electrophoretic
oscillation-assisted
tangent-flow
ultrafiltration
(EPOTF)
process.
Reinforcing
nanofilter
with
electro-spun
poly(vinylidene
fluoride)
(PVDF)
fibers
significantly
improved
durability
under
high-pressure
conditions,
withstanding
nearly
2.8
times
greater
pressures
than
nonreinforced
nanofilters.
The
PVDF-fiber-coated
achieved
flow
rate
of
over
70
mL
min–1,
compared
just
25
min–1
A
filter
housing
system
copper
electrodes
isolated
solution
path
further
enhanced
electrical
stability
entire
system,
widening
EPO
voltage
range
while
reducing
risk
corrosion
and
contamination.
electrode
in
separated
efficiently
prevented
clogging
bioparticle
agglomeration,
maintaining
constant
filtration
performance
across
various
voltages
duty
cycles.
Biochemical
analyses
confirmed
high
concentration
structural
integrity
exosomes
at
rates.
Long-term
tests
verified
superior
PVDF-coated
filters,
successfully
filtering
3400
24
h.
These
results
demonstrate
potential
these
advances
highly
efficient
shape
exosomes,
offering
promise
future
research.
SCRIPTA MEDICA,
Год журнала:
2025,
Номер
56(1), С. 155 - 171
Опубликована: Янв. 1, 2025
Inflammatory
bowel
disease
(IBD),
includes
ulcerative
colitis
(UC)
and
Crohn's
(CD),
is
characterised
by
recurrent,
chronic
inflammation
of
the
gastrointestinal
system.
For
treatment
UC,
oral
medication
delivery
to
colon
largely
favoured
since
it
increases
their
effectiveness
while
lowering
systemic
toxicity.
To
deliver
a
colon,
which
at
distal
end
system
however
challenging,
because
physiological
difficulties,
biochemical
barriers
environmental
obstacles,
such
as
those
brought
on
mucus
epithelium.
Recent
preclinical
studies
have
suggested
that
targeted
administration
using
nanoparticle-based
drug
systems
(DDS)
may
be
promising
strategy
for
UC.
Additionally,
this
study
offers
thorough
assessment
newly
discovered
naturally
produced
nanoparticles
(such
extracellular
vesicles
plant-derived
nanoparticles)
well
DDS
based
synthetic
nanoparticles.
These
innovative
UC
plans
present
chance
clinical
application
nanoparticle
formulae.
