Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment
Chemical Engineering Journal,
Год журнала:
2024,
Номер
490, С. 151756 - 151756
Опубликована: Апрель 30, 2024
Язык: Английский
Multifunctional Silver‐Enzyme Nanogels Assembly with Efficient Trienzyme Cascades for Synergistic Diabetic Wound Healing
Yedong Ma,
Xiyu Lai,
Xi Luo
и другие.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
Diabetic
wound
healing
presents
a
persistent
clinical
challenge,
often
characterized
by
prolonged
times,
and
can
be
particularly
difficult
to
achieve
in
hyperglycemic
environment.
In
this
study,
multi‐functional
silver‐enzyme
nanogels
assembly
(Ag‐nGHC)
is
designed
focusing
on
the
complex
diabetic
Glucose
oxidase
(GOX),
horseradish
peroxidase
(HRP),
catalase
(CAT)
are
modified
within
polymeric
nanogel
layers
assembled
into
large
enzyme
cluster
with
silver
ions.
The
close
attachment
of
three
enzymes
ensures
fast
continuous
consumption
high
level
glucose,
generation
oxygen,
hydroxyl
radicals
(•OH)
around
site.
Meanwhile,
ions
Ag‐nGHC
act
as
an
effective
agent
kill
bacteria.
This
cascade
system
significantly
improves
microenvironment
site
reducing
bacterium
infection
alleviating
hypoxia
well
hyperglycemia.
Sequentially,
improved
environment
facilitates
later
processes
including
anti‐inflammatory,
re‐epithelialization,
angiogenesis,
evidenced
enhancing
polarization
toward
M2
macrophages
increasing
CD31
signals
study.
Overall,
materials
proven
multifunctional
properties
complicated
(attributes
such
adaptability,
hypoxia‐alleviated,
anti‐hyperglycemic,
antimicrobial,
angiogenic)
showed
great
potential
for
treatment
chronic
wound.
Язык: Английский
E-PL/MnO2 nanozymes/gellan gum/hyaluronic acid-based multifunctional hydrogel to promote diabetic wound healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
304, С. 140777 - 140777
Опубликована: Фев. 7, 2025
Язык: Английский
Next‐Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel‐Based Pharmaceuticals for Inflammation Regulation
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Oral
ulcers,
affecting
27.9%
of
adults,
can
lead
to
malnutrition
and
dehydration,
especially
in
individuals
with
diabetes,
cancer,
viral
infections,
autoimmune
diseases.
Existing
treatments-including
oral
films,
sprays,
frosts,
powders-often
fail
be
effective
due
rapid
dilution
clearance
the
moist
environment.
This
study
is
first
investigate
use
Cold
Atmospheric
Plasma
(CAP)
for
treating
ulcers
its
underlying
molecular
mechanisms.
A
novel
high-bioavailability,
mucoadhesive
therapy
combining
handheld
three
dimensions
(3D)
multi-microhole
CAP
developed
a
nanogel-based
pharmaceutical
system
containing
glucose
oxidase
(GOx)
catalase
(CAT),
termed
GCN.
These
results
showed
that
both
alone
combined
GCN
significantly
accelerate
ulcer
healing,
modulate
immune
responses,
activate
Epidermal
Growth
Factor
Receptor
(EGFR)
acetic
acid-induced
outperforming
untreated
controls
conventional
medication,
Watermelon
Frost
(WF).
Furthermore,
CAP+GCN
combination
enhances
therapeutic
effects
by
promoting
fibroblast
generation.
pretreatment
also
cell
permeability
nanoparticle
uptake,
improving
tissue
adhesion.
findings
are
validated
primary
Human
Gingival
Fibroblasts
(HGF)
Periodontal
Ligament
Stem
Cells
(PDLSC)
from
healthy
donors,
as
well
an
model
rats,
demonstrating
superior
biocompatibility
safety.
Язык: Английский
In-situ Oxygen-Supplying ROS Nanopurifier for Enhanced Healing of MRSA-Infected Diabetic Wounds via Microenvironment Modulation
Acta Biomaterialia,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
In vitro assembly of the trehalose bi-enzyme complex with artificial scaffold protein
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Авг. 29, 2023
Introduction:
Trehalose
is
a
significant
rare
sugar
known
for
its
stable
properties
and
ability
to
protect
biomolecules
from
environmental
factors.
Methods:
In
this
study,
we
present
novel
approach
utilizing
scaffold
protein-mediated
assembly
method
the
formation
of
trehalose
bi-enzyme
complex.
This
complex
consists
maltooligosyltrehalose
synthase
(MTSase)
trehalohydrolase
(MTHase),
which
work
in
tandem
catalyze
substrate
enhance
overall
catalytic
efficiency.
Utilizing
specific
interaction
between
cohesin
dockerin,
study
presents
implementation
an
assembly,
analysis
efficiency,
exploration
strategies
enzyme
utilization
through
construction
under
optimal
conditions
vitro.
Results
Discussion:
The
demonstrated
production
level
1.5
times
higher
than
that
free
mixture
at
40
h,
with
sustained
upward
trend.
Compared
mixtures,
adoption
may
improve
cascade
reactions
effects,
thus
presenting
promising
prospects.
Язык: Английский
A Cohort Study on the Outcome of Diabetic Foot Ulcers
Sriram Sanjeeviraj,
Aswinkumar Subburaj,
Smriti Aluri
и другие.
Cureus,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 31, 2023
Diabetic
foot
ulcers
(DFUs)
represent
a
significant
and
challenging
complication
of
diabetes
mellitus,
often
leading
to
serious
morbidity
substantial
burden
on
healthcare
systems.
The
study
was
conducted
with
the
objectives
evaluating
outcomes
DFUs.A
cohort
evaluate
DFUs
from
May
2019
2020
at
tertiary
care
hospital
located
in
Chennai.
included
patients
aged
18
90
years
who
were
diagnosed
DFUs.
Individuals
diabetic
lesions
(skin
such
as
fissures,
abscess,
cellulites)
other
than
or
those
without
excluded.
data
collected
total
100
using
systematic
random
sampling
technique.The
mean
(SD)
age
participants
54.68
(6.72)
males
constituting
56%
population.
Among
participants,
65%
experienced
healing
while
35%
did
not.
Logistic
regression
analysis
showed
that
glycated
haemoglobin
(HbA1c)
levels,
age,
duration
had
effect
patient
outcome.
HbA1c
Out
12
major
amputation,
seven
(58.3%)
survived,
out
19
minor
amputations,
(94.7%)
remarkably
higher
survival
rate.
Meanwhile,
100%
rate
observed
no
amputation.The
study's
comprehensive
assessment
risk
factors
their
associations
provides
essential
knowledge
for
clinical
practice.
findings
collectively
support
optimization
interventions
strategies
prevent
manage
DFUs,
ultimately
improving
enhancing
quality
life.
highlights
significance
glycemic
control
limb
preservation
DFU
management.
Язык: Английский
Utilization of Nanogels Extract Leaf Binahong on Palatal Wound Healing
Archives of The Medicine and Case Reports,
Год журнала:
2024,
Номер
5(2), С. 667 - 672
Опубликована: Фев. 1, 2024
The
palatal
wound
is
difficult
to
heal
related
activity
of
eating
and
chewing,
so
needed
system
delivers
drugs
materials
that
can
help
speed
up
the
healing.
Leaf
binahong's
content
saponins,
tannins,
alkaloids,
flavonoids,
vitamin
C.
Content
cause
leaf
binahong
characteristic
antibacterial,
antiviral,
anti-inflammatory,
analgesic,
antioxidants
important
for
preparation
nanogels
in
application
biomedical
pharmacy
has
lots
used,
however,
use
extract
still
needs
discussion
more
continue.
Writing
this
aim
see
potency
mucosa
healing
was
reviewed
various
studies
before.
Several
have
disclosed
healing,
both
on
skin
as
well
cavity
mouth
through
enhancement
fibroblasts,
collagen,
another
factor.
Based
matter
they
conclude
potentially
Язык: Английский