Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
273, С. 132579 - 132579
Опубликована: Май 23, 2024
Язык: Английский
Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(2), С. 10 - 10
Опубликована: Апрель 9, 2025
Nanotheranostics—where
nanoscale
materials
serve
both
diagnostic
and
therapeutic
functions—are
rapidly
transforming
gene
therapy
by
tackling
critical
delivery
challenges.
This
review
explores
the
design
engineering
of
various
nanoparticle
systems
(lipid-based,
polymeric,
inorganic,
hybrid)
to
enhance
stability,
targeting,
endosomal
escape
genetic
payloads.
We
discuss
how
real-time
imaging
capabilities
integrated
into
these
platforms
enable
precise
localization
controlled
release
genes,
improving
treatment
efficacy
while
reducing
off-target
effects.
Key
strategies
overcome
barriers
(such
as
proton
sponge
effect
photothermal
disruption)
achieve
nuclear
are
highlighted,
along
with
recent
advances
in
stimuli-responsive
that
facilitate
spatiotemporal
control
expression.
Clinical
trials
preclinical
studies
demonstrate
expanding
role
nanotheranostics
managing
cancer,
inherited
disorders,
cardiovascular
neurological
diseases.
further
address
regulatory
manufacturing
hurdles
must
be
for
widespread
clinical
adoption
nanoparticle-based
therapies.
By
synthesizing
progress
ongoing
challenges,
this
underscores
transformative
potential
effective,
targeted,
image-guided
delivery.
Язык: Английский
Advanced Generation Therapeutics: Biomimetic Nanodelivery System for Tumor Immunotherapy
ACS Nano,
Год журнала:
2023,
Номер
17(24), С. 24593 - 24618
Опубликована: Дек. 6, 2023
Tumor
immunotherapy
is
a
safe
and
effective
strategy
for
precision
medicine.
However,
most
cancer
cases
still
ends
in
failure,
with
the
root
causes
of
immunosuppressive
extraordinary
heterogeneity
solid
tumors
microenvironment.
The
emerging
biomimetic
nanodelivery
system
provides
promising
tactic
to
improve
effect
while
reducing
adverse
reactions
on
nontarget
cells.
Herein,
we
summarize
relationship
between
tumor
occurrence
immune
microenvironment,
mechanism
escape,
classification
(including
adoptive
cellular
therapy,
cytokines,
vaccines,
checkpoint
inhibitors)
recommend
target
cells
first,
then
emphatically
introduce
recent
advances
applications
latest
systems
(e.g.,
cells,
erythrocytes,
platelets,
bacteria)
immunotherapy.
Meanwhile,
separately
application
vaccines.
Finally,
predictable
challenges
perspectives
forward
exploration
are
also
discussed.
Язык: Английский
Gene Drug Delivery for the Treatment of Cancer
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 55 - 86
Опубликована: Март 7, 2025
Gene
drug
delivery
is
a
pivotal
approach
in
modern
cancer
treatment,
offering
targeted
therapies
that
overcome
the
limitations
of
conventional
methods.
This
chapter
delves
into
significance
gene
therapy
oncology,
highlighting
key
mechanisms
like
silencing,
suicide
genes,
and
tumor
suppressor
replacement
to
inhibit
progression.
Advanced
systems
are
essential
for
effective
therapy.
The
explores
nanocarriers
both
viral
nonviral
methods
as
critical
tools
improving
precision.
editing
technologies
CRISPR-Cas9
also
investigated
their
potential
transform
treatment.
integration
with
other
modalities,
such
immunotherapy
personalized
medicine,
proposed
way
improve
patient
outcomes.
Future
directions
developing
trends
therapy,
including
innovations
persistent
obstacles
clinical
translation,
explored.
offers
concise
overview
current
future
prospects
Язык: Английский
Stimulus-Responsive Nanodelivery and Release Systems for Cancer Gene Therapy: Efficacy Improvement Strategies
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7099 - 7121
Опубликована: Июль 1, 2024
Abstract:
Introduction
of
exogenous
genes
into
target
cells
to
overcome
various
tumor
diseases
caused
by
genetic
defects
or
abnormalities
and
gene
therapy,
a
new
treatment
method,
provides
promising
strategy
for
treatment.
Over
the
past
decade,
therapy
has
made
exciting
progress;
however,
it
still
faces
challenge
low
nucleic
acid
delivery
release
efficiencies.
The
emergence
nonviral
vectors,
primarily
nanodelivery
systems
(NDRS),
resulted
in
historic
breakthrough
application
therapy.
NDRS,
especially
stimulus-responsive
NDRS
that
can
respond
timely
manner
changes
internal
external
microenvironment
(eg,
pH,
high
concentration
glutathione/reactive
oxygen
species,
overexpressed
enzymes,
temperature,
light,
ultrasound,
magnetic
field),
shown
excellent
loading
advantages
precision
efficiency
been
widely
applied.
only
disadvantage
is
poor
transfection
limits
in-depth
clinical
practice,
owing
presence
biological
barriers
body.
Therefore,
this
review
first
introduces
development
history
current
obstacles
faced
delivery,
strategies
these
obstacles,
conventional
then
focuses
on
latest
research
progress
improving
efficiency.
Finally,
future
challenges
prospects
may
face
transformation
are
discussed
provide
references
enhancing
Keywords:
treatment,
efficiency,
microenvironment,
physiological
barrier,
efficacy
improvement
Язык: Английский
Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
282, С. 137047 - 137047
Опубликована: Ноя. 1, 2024
Язык: Английский
Cancer‐derived non‐coding RNAs endow tumor microenvironment with immunosuppressive properties
Wiley Interdisciplinary Reviews - RNA,
Год журнала:
2023,
Номер
15(1)
Опубликована: Окт. 10, 2023
Non-coding
RNAs
(ncRNAs)
have
attracted
extensive
attention
due
to
their
vital
roles
in
tumorigenesis
and
progression,
especially
the
immunotherapy
resistance.
Tumor
resistance
is
a
crucial
factor
hindering
efficacy
of
tumor
treatments,
which
can
be
largely
attributed
immunosuppressive
properties
microenvironment.
Current
studies
revealed
that
cancer-derived
ncRNAs
are
involved
formation
microenvironment
(TIME)
through
multiple
ways.
They
not
only
promote
expression
immune
checkpoint
ligands
(e.g.,
PD-L1,
CD47,
Gal-9,
CD276)
on
cancer
cell
surfaces,
but
also
enhance
secretion
cytokines
TGF-β,
IL-6,
IL-10,
VEGF,
chemokines).
Cancer-derived
could
transferred
into
surrounding
immune-related
cells
extracellular
vesicles,
thereby
inhibiting
cytotoxicity
CD8+
T
NK
cells,
restraining
DC-mediated
antigen
presentation,
inducing
phenotype
transformation
TAMs
CAFs,
enhancing
functions
Tregs
MDSCs.
Herein,
we
summarize
regulating
TIME
further
explore
potential
applications
as
prognostic
biomarkers
immunotherapeutic
targets,
will
help
us
address
TIME-mediated
future.
This
article
categorized
under:
RNA
Disease
Development
>
Regulatory
RNAs/RNAi/Riboswitches
RNAs.
Язык: Английский
Delivery of nucleic acids using nanomaterials
Molecular Biomedicine,
Год журнала:
2023,
Номер
4(1)
Опубликована: Дек. 14, 2023
The
increasing
number
of
approved
nucleic
acid
therapeutics
demonstrates
the
potential
for
prevention
and
treatment
a
broad
spectrum
diseases.
This
trend
underscores
significant
impact
promise
acid-based
treatments
in
field
medicine.
Nevertheless,
employing
acids
as
is
challenging
due
to
their
susceptibility
degradation
by
nucleases
unfavorable
physicochemical
characteristics
that
hinder
delivery
into
cells.
Appropriate
vectors
play
pivotal
role
improving
stability
delivering
specific
maturation
systems
has
led
breakthroughs
development
based
on
such
DNA,
siRNA,
mRNA.
Non-viral
have
gained
prominence
among
myriad
nanomaterials
low
immunogenicity,
ease
manufacturing,
simplicity
cost-effective,
large-scale
production.
Here,
we
provide
an
overview
recent
advancements
delivery.
Specifically,
give
detailed
introduction
polymers,
lipids,
polymer-lipid
hybrids,
comprehensive
descriptions
applications
Also,
biological
barriers,
administration
routes,
strategies
organ-selective
are
discussed.
In
summary,
this
review
offers
insights
rational
design
next-generation
Язык: Английский
Review on gene and cell therapies in prostate cancer treatment: prospects and challenges
Journal of Translational Genetics and Genomics,
Год журнала:
2025,
Номер
9(2), С. 62 - 75
Опубликована: Март 21, 2025
Gene
and
cell
therapies
have
emerged
as
innovative
therapeutic
strategies,
offering
a
new
paradigm
in
the
treatment
of
prostate
cancer.
This
review
explores
current
state
gene
therapies,
including
their
mechanisms,
applications,
challenges
faced
clinical
translation.
The
article
selection
was
based
on
2020
preferred
reporting
items
for
systematic
reviews
meta-analyses
(PRISMA).
Eighty-four
(84)
articles
(published
English
between
2018
2024)
from
standard
electronic
databases
were
extracted
reviewed.
Key
approaches
such
viral
vector-mediated
delivery,
CRISPR-Cas9
editing,
suicide
genes,
cell-based
like
CAR
T
therapy,
dendritic
vaccines
that
target
specific
tumor
antigens
These
promise
to
enhance
efficacy
with
few
challenges,
off-target
effects,
limited
delivery
efficiency,
immune-related
toxicities
associated
delivery.
Advances
cells,
nanoparticle-based
systems,
epigenetic
modulation
are
potential
solutions
these
challenges.
Combination
involving
immunotherapies
oncolytic
viruses
hold
synergistic
effects.
Certain
critical
regulatory,
ethical,
accessibility
issues
must
be
addressed
ensure
safe
equitable
deployment
therapies.
Continued
research
innovation
streamlined
regulatory
pathways
will
crucial
realizing
full
treating
Overcoming
fears
confronting
worldwide
might
facilitate
stream
personalized
medicine
oncology.
Язык: Английский