Biomedical Application of MSCs in Corneal Regeneration and Repair
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 695 - 695
Опубликована: Янв. 15, 2025
The
World
Health
Organization
estimates
that
approximately
285
million
people
suffer
from
visual
impairments,
around
5%
of
which
are
caused
by
corneal
pathologies.
Currently,
the
most
common
clinical
treatment
consists
a
transplant
(keratoplasty)
human
donor.
However,
worldwide
demand
for
donor
corneas
amply
exceeds
available
supply.
Lamellar
keratoplasty
(transplantation
replacement
only
one
three
layers
cornea)
is
partially
solving
problem
cornea
undersupply.
Obviously,
cell
therapy
applied
to
every
these
will
expand
current
therapeutic
options,
reducing
cost
ophthalmological
interventions
and
increasing
effectiveness
surgery.
Mesenchymal
stem
cells
(MSCs)
adult
with
capacity
self-renewal
differentiation
into
different
lineages.
They
can
be
obtained
many
tissues,
such
as
bone
marrow,
umbilical
cord,
adipose
tissue,
dental
pulp,
skin,
cornea.
Their
ease
collection
advantages
over
embryonic
or
induced
pluripotent
make
them
very
practical
source
experimental
potential
applications.
In
this
review,
we
focus
on
recent
advances
using
MSCs
sources
replace
damaged
layers,
at
both
preclinical
levels
specific
diseases.
Язык: Английский
Top2b regulates morphological and migratory properties of retinal progenitor cells in vivo and upon transplantable matrix substrates
Alexandra C. Dabrowski,
Alison Logan,
Rameshwari Rayaji
и другие.
Опубликована: Апрель 14, 2025
Aim:
This
study
evaluated
the
impact
of
retinal
extracellular
matrix
(ECM)
and
key
biomaterial
substrates
on
motility
transplantable
cells
with
genomic
manipulation,
using
therapeutic
molecule,
Topoisomerase
II
beta
(Top2b),
as
a
model.
Methods:
Tests
first
applied
in
ovo
electroporation
to
examine
effects
pharmacological
Top2b
inhibitor
(ICRF-193)
progenitor
development
embryonic
retina.
Complementary
qRT-PCR
tests
measured
changes
select
cadherin
molecules
response
treatment.
In
vitro
transfection
produced
cultured
cell
groups
overexpression
knockdown.
Differences
adhesion
altered
groups,
compared
wildtype
cells,
were
upon
used
emerging
transplantation
matrixes.
Results:
Data
illustrated
significant
differences
number
spacing
ganglion
when
retina
was
treated
ICRF-193,
well
downregulation
several
molecules.
Cultured
progenitors
knockdown
exhibited
different
expression
chemotactic
receptors,
parameters,
modalities
migration
laminin,
poly-L-lysine,
collagen
IV.
Significant
morphology
surface
area
also
cells.
Conclusions:
Corroborating
vivo
data
support
target
for
but
indicate
transplantation.
These
highlight
advantages
bioinspired
materials
developed
aid
replacement
modified
genetic
improve
outcomes
across
nervous
system.
Язык: Английский
Role of borneol as enhancer in drug formulation: A review
Chinese Herbal Medicines,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
As
a
traditional
Chinese
medicine
(TCM),
borneol
has
shown
superior
ability
for
anti-inflammatory
and
analgesic
activities
when
coupled
with
other
active
ingredients
from
ancient
times.
Furthermore,
is
believed
to
improve
blood
concentration
bioavailability
of
drugs.
Thus,
it
been
paired
various
TCM
formulas
since
time.
The
physiological
barriers
in
human
can
cause
significant
limitations
drug
efficiency
as
the
primarily
restricted
entering
into
brain.
Borneol
proven
enhance
permeability
biological
such
blood-brain,
transdermal,
corneal,
intestinal
barriers.
Moreover,
growing
interest
delivery
system
design
trans-barrier
transport
involving
borneol.
Nano-drug
increased
surface
area
improved
sites,
applied
increase
bioactivity
water
insoluble
used
efficacy
by
reducing
time
action
compared
conventional
administration
approach
formulas.
Given
its
cross-barrier
permeation
efficacy,
integrated
precise
prolonged
targeting
at
tumor
sites.
However,
preparation
consisting
still
face
great
challenges.
Current
research
fails
unravel
difference
mechanism
between
nano-drug
systems
comprised
Enhanced
penetration
rarely
verified
identical
formulation
regarding
dosage
medical
indications.
This
study
outlines
current
state
on
properties,
pharmacological
effects
borneol,
allowing
cross-comparison
single
compound
classical
aims
provide
insights
borneol-based
enhanced
formulation,
potential
development
bioavailability.
Язык: Английский
Atrophic Macular Degeneration and Stem Cell Therapy: A Clinical Review
Advances in experimental medicine and biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Nanotechnology in retinal diseases: From disease diagnosis to therapeutic applications
Biophysics Reviews,
Год журнала:
2024,
Номер
5(4)
Опубликована: Ноя. 5, 2024
Nanotechnology
has
demonstrated
tremendous
promise
in
the
realm
of
ocular
illnesses,
with
applications
for
disease
detection
and
therapeutic
interventions.
The
nanoscale
features
nanoparticles
enable
their
precise
interactions
retinal
tissues,
allowing
more
efficient
effective
treatments.
Because
biological
organs
are
compatible
diverse
nanomaterials,
such
as
nanoparticles,
nanowires,
nanoscaffolds,
hybrid
nanostructures,
usage
biomedical
applications,
particularly
increased.
use
nanotechnology
medicine
is
advancing
rapidly,
recent
advances
nanomedicine-based
diagnosis
therapy
techniques
may
provide
considerable
benefits
addressing
primary
causes
blindness
related
to
illnesses.
current
state,
prospects,
challenges
monitoring
nanostructures
or
cells
eye
application
regenerative
ophthalmology
have
been
discussed
thoroughly
reviewed.
In
this
review,
we
build
on
our
previously
published
review
article
2021,
where
impact
nano-biomaterials
regeneration.
However,
extended
focus
incorporate
discuss
all
diseases,
a
highlight
diagnostic
research
studies.
Язык: Английский