Amorphous calcium phosphate reinforced alginate-dialdehyde-gelatin (ADA-GEL) bioink for biofabrication of bone tissue scaffolds
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2025,
Номер
unknown, С. 100710 - 100710
Опубликована: Фев. 1, 2025
Язык: Английский
Calcium Phosphates: A Key to Next‐Generation In Vitro Bone Modeling
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(29)
Опубликована: Авг. 23, 2024
Abstract
The
replication
of
bone
physiology
under
laboratory
conditions
is
a
prime
target
behind
the
development
in
vitro
models.
model
should
be
robust
enough
to
elicit
an
unbiased
response
when
stimulated
experimentally,
giving
reproducible
outcomes.
In
tissue
generation
majorly
requires
availability
cellular
components,
presence
factors
promoting
proliferation
and
differentiation,
efficient
nutrient
supply,
supporting
matrix
for
cells
anchor
–
gaining
predefined
topology.
Calcium
phosphates
(CaP)
are
difficult
ignore
while
considering
above
requirements
model.
Therefore,
current
review
focuses
on
role
CaP
developing
addressing
prerequisites
generation.
Special
emphasis
given
physico‐chemical
properties
that
promote
osteogenesis,
angiogenesis
provide
sufficient
mechanical
strength
load‐bearing
applications.
Finally,
future
course
action
discussed
ensure
utilization
field.
Язык: Английский
Enzymatic synthesis of calcium phosphates: A review
Nano-Structures & Nano-Objects,
Год журнала:
2024,
Номер
39, С. 101214 - 101214
Опубликована: Июнь 19, 2024
Язык: Английский
A Moldable, Tough Mineral‐Dominated Nanocomposite as a Recyclable Structural Material
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 5, 2025
Flexible
hybrid
minerals,
primarily
composed
of
inorganic
ionic
crystal
nanolines
and
a
small
amount
organic
molecules,
have
significant
potential
for
the
development
sustainable
structural
materials.
However,
weak
interactions
insufficient
crosslinking
among
limit
mechanical
enhancement
application
these
minerals
in
high-strength
Inspired
by
tough
biominerals
modern
reinforced
concrete
structures,
this
study
proposes
introducing
an
aramid
nanofiber
(ANF)
network
as
flexible
framework
during
polymerization
calcium
phosphate
oligomers
(CPO),
crosslinked
polyvinyl
alcohol
(PVA)
sodium
alginate
(SA).
This
approach
allows
formed
through
CPO
to
be
integrated
into
framework,
thereby
creating
mineral-based
materials
(inorganic
content:
70.7
wt.%),
denoted
PVA/SA/ANF/CPO
(PSAC).
The
multiple
intermolecular
between
phases,
combined
with
nano-reinforced
structure,
endow
PSAC
significantly
enhanced
tensile
strength
(86.6
±
8.6
MPa),
comparable
that
polymer
plastics.
Moreover,
possesses
excellent
plasticity
flame
retardancy.
noncovalent
molecular
within
enable
efficient
recyclability.
Consequently,
has
replace
plastics
components,
providing
promising
avenue
developing
toughness
Язык: Английский
Controlled Release of Growth Differentiation Factor 5 from Polyethylene Glycol-Stabilized Amorphous Calcium Phosphate Nanoparticle Electrospun Fibers to Promote Periodontal Bone Regeneration
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Язык: Английский
Fabrication of calcium phosphate nanoparticles immobilizing copper nanoclusters for in situ synthesis of an anti-cancer agent
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Год журнала:
2025,
Номер
unknown, С. 136940 - 136940
Опубликована: Апрель 1, 2025
Язык: Английский
Development of nanocomposite hydrogel using citrate-containing amorphous calcium phosphate and gelatin methacrylate
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 10, 2024
Nanocomposite
hydrogels
are
suitable
in
bone
tissue
engineering
due
to
their
resemblance
with
the
extracellular
matrix,
ability
match
complex
geometries,
and
provide
a
framework
for
cell
attachment
proliferation.
The
nanocomposite
hydrogel
comprises
organic
inorganic
counterparts.
Gelatin
methacrylate
(GELMA)
is
an
extensively
used
biomaterial
its
excellent
biocompatibility,
biodegradability,
bioactivity.
photo-crosslinking
of
GELMA
presents
challenge
when
aiming
create
thicker
opacity
induced
by
fillers,
which
obstructs
penetration
ultraviolet
(UV)
light.
Therefore,
using
chemical
crosslinking
approach,
we
have
developed
this
study
incorporating
citrate-containing
amorphous
calcium
phosphate
(ACP_CIT).
Ammonium
persulfate
(APS)
Tetramethylethylenediamine
(TEMED)
were
deployed
crosslink
group
GELMA.
oscillatory
shear
tests
confirmed
that
enhances
both
storage
(G′)
loss
modulus
(G″)
Subsequently,
incorporation
ACP_CIT
shows
further
enhancement
G′
G″
values.
In
vitro
analysis
revealed
do
not
compromise
cytocompatibility
Hence,
developing
employing
APS/TEMED
emerges
as
promising
alternative
photo-crosslinking.
Язык: Английский
Development and Characterization of Thermoresponsive Double‐Network Nanocomposite Hydrogel for Bone Tissue Engineering
Macromolecular Materials and Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Abstract
In
this
study,
a
thermoresponsive
double‐network
(DN)
nanocomposite
hydrogel
is
developed.
The
primary
network
comprises
Pluronic
P123,
while
the
secondary
gelatinmethacrylate
(GELMA)
and
polyacrylamide
(PAM).
A
systematic
approach
adopted
to
develop
DN
hydrogels.
Initially,
impact
of
P123
concentrationon
mechanical
properties
PAM‐GELMA
investigated.
Results
from
tensile
strength
oscillatory
shear
tests
reveal
that
an
increasing
concentration
has
marginal
effect
on
storage
modulus
significantly
reducing
loss
hydrogel,
thereby
improving
properties.
Notably,
DN3
containing
7.5w/v%
in
exhibits
osteoid
matrix‐like
To
further
enhance
properties,
citrate‐containing
amorphous
calcium
phosphate
(ACP_CIT)
incorporated
at
varying
concentrations.
At
lower
ACP_CIT
(0.75
w/v%),
DN3‐ACP0.75
are
notably
enhanced.
Incorporating
(DN3‐ACP0.75)
decreases
creep
strain,
rapid
stress
relaxation,
reduced
water
uptake
capacity
maintaining
behavior.
Finally,
vitro
analysis
confirms
cytocompatibility
hydrogels
with
MC3T3‐E1
cells,
indicating
potential
use
bone
tissue
engineering.
Язык: Английский
Enhanced biological activity of ACPs/cc/cs/PVA composite bone cement: a study on degradation, mineralization, and bone repair properties
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 9
Опубликована: Дек. 9, 2024
The
application
of
calcium
phosphate
cement
in
bone
repair
is
often
limited
by
its
restricted
degradation
and
mineralization
capabilities.
Here,
we
developed
a
novel
composite
material
integrating
amorphous
phosphates
(ACPs)
citrate
(CC)
to
enhance
biological
activity.
was
combined
with
powdered
chitosan
(CS)
liquid
polyvinyl
alcohol
(PVA)
formulate
the
ACPs/CC/CS/PVA
cement.
We
investigated
influence
varying
PVA
concentrations
(0.3%,
0.6%,
1.0%,
1.5%)
on
cement's
setting
time,
hydrophilicity,
compressive
strength,
pH,
release
rate,
rate.
find
demonstrates
favorable
injectability
anti-washout
characteristics
within
concentration
range
0.3–1.5%.
An
elevated
correlated
enhanced
properties
improved
reaching
42.8
MPa,
which
essential
for
maintaining
mechanical
stability
at
defect
site.
Additionally,
1.5%
formulation
ensures
an
adequate
ion
(6.5–9.5
mg/L)
beginning
repair.
Furthermore,
vivo
animal
studies
have
confirmed
biocompatibility
Controlled
Ca2+
PO43−
ions
from
ACPs
suggested
facilitate
osteoconduction
osteogenesis,
highlighting
material's
prospect
applications.
Язык: Английский