Balkan Medical Journal,
Год журнала:
2024,
Номер
41(6), С. 419 - 420
Опубликована: Авг. 16, 2024
ErdoğanGenome
editing
technologies
have
demonstrated
significant
potential
for
treating
diseases
caused
by
various
molecular
changes.These
include
cancer,
cystic
fibrosis,
diabetes,
sickle
cell
anemia,
heart
diseases,
and
rare
genetic
disorders.
1,2Genome
also
offer
solutions
neurodegenerative
such
as
Alzheimer's
Huntington's
disease
neuromuscular
disorders
Duchenne's
muscular
dystrophy,
spinal
atrophy,
amyotrophic
lateral
sclerosis.The
leading
genome
are
zinc-finger
nucleases,
transcription
activatorlike
effector
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)/CRISPR-associated
protein
9
(Cas9).Among
these
technologies,
CRISPR/Cas9
is
the
most
widely
used
due
to
its
versatility,
effectiveness,
efficiency,
ease
of
application.
3his
groundbreaking
manipulation
tool
revolutionizing
scientific
research,
medical
diagnostics,
therapeutic
applications.Major
advancements
in
efficacy
propelled
strategies
phase
3
human
clinical
trials.However,
CRISPR
technology
associated
with
some
challenges
high
costs,
ineffective
delivery
methods
specific
targets,
poor
efficiency
processes,
particularly
offtarget
effects.
3,
Food Chemistry X,
Год журнала:
2024,
Номер
22, С. 101309 - 101309
Опубликована: Март 19, 2024
The
increasing
global
population
drives
a
rising
demand
for
food,
particularly
fish
as
preferred
protein
source,
straining
capture
fisheries.
Overfishing
has
depleted
wild
stocks,
emphasizing
the
need
advanced
aquaculture
technologies.
Unlike
agriculture,
not
seen
substantial
technological
advancements.
Artificial
Intelligence
(AI)
tools
like
Internet
of
Things
(IoT),
machine
learning,
cameras,
and
algorithms
offer
solutions
to
reduce
human
intervention,
enhance
productivity,
monitor
health,
feed
optimization,
water
resource
management.
However,
challenges
such
data
collection,
standardization,
model
accuracy,
interpretability,
integration
with
existing
systems
persist.
This
review
explores
adoption
AI
techniques
advance
industry
bridge
gap
between
food
supply
demand.
Biotechnology Advances,
Год журнала:
2024,
Номер
74, С. 108401 - 108401
Опубликована: Июнь 27, 2024
Metabolic
burden
is
defined
by
the
influence
of
genetic
manipulation
and
environmental
perturbations
on
distribution
cellular
resources.
The
rewiring
microbial
metabolism
for
bio-based
chemical
production
often
leads
to
a
metabolic
burden,
followed
adverse
physiological
effects,
such
as
impaired
cell
growth
low
product
yields.
Alleviating
imposed
undesirable
changes
has
become
an
increasingly
attractive
approach
constructing
robust
factories.
In
this
review,
we
provide
brief
overview
engineering,
focusing
specifically
recent
developments
strategies
diminishing
while
improving
robustness
yield.
A
variety
examples
are
presented
showcase
promise
engineering
in
facilitating
design
construction
Finally,
challenges
limitations
encountered
discussed.
International Journal of Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
ABSTRACT
The
concept
of
aging
has
evolved
from
being
primarily
attributed
to
genetic
factors
recognizing
the
critical
role
epigenetic
mechanisms.
Recent
advancements,
such
as
clocks,
have
provided
tools
assess
biological
age
and
offer
insights
into
processes
at
molecular
level.
In
aesthetic
dermatology,
understanding
these
allows
for
more
personalized,
effective
interventions
targeting
root
causes
skin
aging.
This
review
explores
interplay
changes,
aging,
potential
personalized
care
enhance
longevity
rejuvenation.
is
based
on
an
extensive
literature
search
conducted
across
PubMed
other
scientific
databases.
Studies
focused
mechanisms
DNA
methylation,
histone
modifications,
their
relationship
Particular
attention
was
given
recent
advancements
in
including
Horvath's
Clock
GrimAge,
implications
dermatological
treatments.
Epigenetic
Clock,
demonstrated
utility
assessing
through
methylation
markers,
revealing
actionable
processes.
Energy‐based
devices
like
fractional
lasers
radiofrequency
shown
promise
reversing
age‐related
promoting
collagen
synthesis,
reducing
age.
Additionally,
lifestyle
diet,
sleep,
circadian
rhythm
alignment
significantly
influence
health.
Integrating
dermatology
represents
a
paradigm
shift
rejuvenation,
allowing
treatments
that
address
visible
signs
underlying
Using
clocks
provides
framework
tailoring
individual
patient
needs,
optimizing
outcomes,
extending
results.
Future
research
should
focus
longitudinal
studies,
accessibility,
ethical
considerations
fully
harness
epigenetics
health
overall
well‐being.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(5), С. 4147 - 4185
Опубликована: Апрель 30, 2024
Recent
years
have
witnessed
unprecedented
progress
in
therapeutic
gene
editing,
revolutionizing
the
approach
to
treating
genetic
disorders.
In
this
comprehensive
review,
we
discuss
progression
of
milestones
leading
emergence
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)-based
technology
as
a
powerful
tool
for
precise
and
targeted
modifications
human
genome.
CRISPR-Cas9
nuclease,
base
prime
editing
taken
center
stage,
demonstrating
remarkable
precision
efficacy
ex
vivo
genomic
modifications.
Enhanced
delivery
systems,
including
viral
vectors
nanoparticles,
further
improved
efficiency
safety
advancing
their
clinical
translatability.
The
exploration
CRISPR-Cas
systems
beyond
commonly
used
Cas9,
such
development
Cas12
Cas13
variants,
has
expanded
repertoire
tools,
enabling
more
intricate
interventions.
Outstandingly,
represents
significant
leap
forward,
given
its
unparalleled
versatility
minimization
off-target
effects.
These
innovations
paved
way
multitude
previously
incurable
disorders,
ranging
from
monogenic
diseases
complex
polygenic
conditions.
This
review
highlights
latest
innovative
studies
field,
emphasizing
breakthrough
technologies
preclinical
trials,
applications
realm
medicine.
However,
challenges
effects
ethical
considerations
remain,
necessitating
continued
research
refine
profiles
frameworks.
Abstract
This
review
focuses
on
the
intersection
of
artificial
intelligence
and
genomic
data
in
cancer
research.
It
explores
types
used
literature,
methodologies
machine
learning
deep
learning,
recent
applications,
challenges
associated
with
this
field.
Through
an
analysis
47,586
articles
addressing
seven
research
questions,
study
reveals
significant
growth
area
over
past
years.
While
there
has
been
remarkable
progress,
ongoing
attention
is
needed
to
address
ethical
considerations,
interpretability
algorithms,
potential
biases,
ensure
reliable
responsible
use
these
advanced
technologies.
Overall,
paper
provides
a
comprehensive
overview
current
landscape,
offering
insights
into
both
AI
Journal of Bio-X Research,
Год журнала:
2024,
Номер
7
Опубликована: Янв. 1, 2024
Artificial
intelligence
(AI)
and
machine
learning
(ML)
are
revolutionizing
the
pharmaceutical
industry,
particularly
in
drug
development
delivery.
These
technologies
enable
precision
medicine
by
analyzing
extensive
datasets
to
optimize
formulations
predict
patient
responses.
AI-driven
models
enhance
nanoparticle-based
carriers,
improving
their
stability,
bioavailability,
targeting
accuracy.
ML
also
facilitates
real-time
monitoring
adaptive
control
of
release,
ensuring
better
therapeutic
outcomes.
This
review
explores
integration
AI
delivery,
highlighting
potential
accelerate
development,
reduce
costs,
advance
personalized
medicine.
Theoretical and Natural Science,
Год журнала:
2025,
Номер
90(1), С. 48 - 53
Опубликована: Янв. 15, 2025
As
an
important
part
of
modern
biotechnology,
genetic
engineering
is
widely
used
in
fields
such
as
disease
treatment,
agricultural
improvement,
and
environmental
protection.
Gene
sequencing
technology,
especially
next-generation
provides
a
powerful
tool
for
studying
biological
information.
However,
with
the
rapid
growth
genomic
data,
how
to
efficiently
accurately
analyze
apply
this
huge
data
has
become
major
challenge
facing
engineering.
In
recent
years,
artificial
intelligence
(AI)
deep
learning,
been
automated
processing
large-scale
shown
great
potential
AI
technology
not
only
shows
advantages
gene
editing
optimization,
variation
detection
genome
association
analysis,
but
also
significantly
improves
efficiency
accuracy
analysis.
Although
brought
many
conveniences
engineering,
challenges
transparency,
quality
issues,
ethics
privacy
protection
still
need
be
solved.
This
article
explores
application
analyzes
can
improve
discusses
contribution
precision
medicine.
continues
develop,
it
expected
play
increasingly
role
genomics,
editing,
medicine,
provide
more
effective
strategies
future
treatment
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 109 - 122
Опубликована: Фев. 5, 2025
Biotechnology
is
in
the
vanguard
of
scientific
advancement,
consistently
pushing
envelope
and
influencing
direction
environmental
sustainability,
agriculture,
healthcare
future
while
genetic
engineering
modifying
an
organism's
makeup,
creating
a
wealth
opportunities
for
advancing
agricultural
output,
addressing
issues,
promoting
human
health.
With
potential
to
completely
change
way
illnesses
are
treated;
this
ground-breaking
technique
gives
patients
with
few
alternatives
past
hope.
Artificial
intelligence
(AI)
replication
machines
built
think
learn
like
people.
Research
on
gene
treatment
as
well
biotechnology
can
greatly
benefit
from
AI.
In
chapter,
authors
will
examine
most
recent
developments
engineering,
biotechnology,
artificial
(AI),
their
possible
uses,
moral
implications,
promising
futures.
