Evaluating the Wound Healing Potential of Characterized Bergenia ciliata–Loaded Salvia hispanica Hydrogel in Diabetic Mice

Microscopy Research and Technique, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

ABSTRACT The current study assessed the wound healing potential of Bergenia ciliata (BC) extract, BC‐loaded Salvia hispanica hydrogel (CH‐BC) and nanoparticles (NPs)–loaded (CH‐BC AgNPs/NPs‐loaded hydrogel) using in vitro vivo studies. prepared its components were analyzed UV–visible spectrophotometry (UV–vis), scanning electron microscopy (SEM), dynamic light scattering (DLS) analysis/particle size analyzer (PSA), zeta potential, fourier transform infrared spectrometry (FT‐IR), x‐ray diffraction (XRD). Peaks peak shifts at 450–460, 250–260, 270–280 nm UV–vis FT‐IR (500–4000 cm −1 ) confirmed extract loading various functional group presence. DLS nanometric BC AgNP while indicated slightly negative charge hydrogel. SEM average topography –mediated (BC AgNPs) AgNPs loaded AgNPs), XRD peaks 2ϴ (10–70) topographical crystalline porous nature materials. showed higher radical scavenging (74.19% ± 1.84%) iron chelation activity (93.70 2.20) 50 25 μL/mL, respectively, CH‐BC produced lowest (48.97% 3.0%) 75 μL/mL (54.35 3.24). Moreover, Chia (CH) synergistically enhanced (1.30%) DPPH scavenging. contraction percentage augmented as potent candidate for (14th day). These findings further supported by a significant ( p < 0.001) restoration MMP2 (184.6 11.7 pg/mL), TIMPs (184.8 15.7 GPx (153.4 11.5 IL‐6 (10 1 pg/mL) levels compared to those diabetic control. normal reepithelization, angiogenesis, maturation wounds treatment groups after histological analysis strengthened supposed rationale that CH, along with AgNPs, can act improve therapeutic results. Hence, appeared sustainable, biocompatible, nontoxic agent paved way futuristic biomedical investigations.

Язык: Английский

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Drug loaded marine polysaccharides-based hydrogel dressings for treating skin burns

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 135779 - 135779

Опубликована: Окт. 17, 2024

Язык: Английский

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The Influence of Basil and Cinnamon Essential Oils on Bioactive Sponge Composites of Collagen Reinforced with Hydroxyapatite

Materials, Год журнала: 2025, Номер 18(3), С. 626 - 626

Опубликована: Янв. 30, 2025

The increasing prevalence of acute traumas, surgical wounds, and chronic skin wounds poses significant therapeutic challenges for wound treatment. One the main concerns in care is danger infection, which a barrier to healing cause higher morbidity mortality rates. emergence drug-resistant bacterial species becoming more frequent every day. Antimicrobial dressings have become viable strategy hospital expense savings. Several factors, such as wound’s localization state, microbial load, cost, must be considered when choosing an appropriate antimicrobial dressing. key goals infection avoidance. This study addresses focusing on prevention combating strains. research explores development novel composite incorporating hydroxyapatite, known its osteoconductive properties, essential oils from basil cinnamon, recognized their activity. evaluates impact these additives properties surface morphology, water absorption, enzymatic degradation, mechanical performance. tests showed that two experimental samples (A1S A1BS) exhibited activity against Escherichia coli but not Staphylococcus aureus. results highlight dressings’ enhanced strength, controlled making them promising candidates advanced healing. Tailored applications were identified, with each dressing composition offering unique benefits specific wound-healing scenarios based balance between flexibility, structural support, bioactivity.

Язык: Английский

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Limb Osseointegration—How Important Is the Role of Nutrition in the Process?

Nutrients, Год журнала: 2025, Номер 17(4), С. 606 - 606

Опубликована: Фев. 7, 2025

Osseointegration (OI) surgery of the appendicular skeleton for repair in amputees is a treatment which metal implant directly fixed to residual bone and subsequently connected prosthetic limb via transcutaneous connector through small incision skin. Current does not consider nutritional advice patients undergoing OI procedure. However, since group very heterogeneous, results may be always satisfactory clinicians. Furthermore, some individuals, incorrect nutrition diet habits lead complications rejection implant. We created an extensive narrative evaluation by conducting methodical search. A comprehensive search was conducted across three major databases: PubMed, Embase, Scopus. The carried out October 2024 with no time limit specified. approach involved using specific, pre-defined terms, were first applied followed Embase Scopus ensure broad diverse range articles captured. process refined considering studies published high-impact journals, as identified based on impact factors subject relevance. To consistency rigor, selection criteria uniformly all databases, irrelevant or incomplete excluded. Based specific nature procedure, it crucial adapt patients' diets after process. translate findings from reviewed literature into practical clinical guidance osseointegration procedures, we developed dietary recommendations both clinicians, presented proposed plans summarized tables. These informed evidence various studies, highlighting that supported randomized controlled trials (RCTs) well areas where remains inconclusive unsupported RCTs. Major vitamins micro- macroelements distinguished guidelines currently most promising therapeutic options amputees. promote efficient tissue healing provide energy rehabilitation, recommended follow healthy, well-balanced contains essential micronutrients, macronutrients, vitamins, minerals. also suggestions future studies.

Язык: Английский

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A Novel Bath Coagulation/Electrospinning Method to Obtain Crosslinked Nanofibers Based on Calcium Alginate and Polyvinyl Alcohol and in Vitro Cytotoxicity Evaluation

Опубликована: Янв. 1, 2025

Язык: Английский

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Applications and prospects of biomaterials in diabetes management

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 7, 2025

Diabetes is a widespread metabolic disorder that presents considerable challenges in its management. Recent advancements biomaterial research have shed light on innovative approaches for the treatment of diabetes. This review examines role biomaterials diabetes diagnosis and treatment, as well their application managing diabetic wounds. By evaluating recent developments alongside future obstacles, highlights promising potential care, underscoring importance enhancing patient outcomes refining methodologies.

Язык: Английский

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Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3051 - 3051

Опубликована: Март 26, 2025

All acute and chronic wound management strategies have limitations. Therefore, there is an urgent need to develop new treatment options for healing. Hydrogels based on natural polymers offer advantages in because they can reduce patients' pain, fight infection, carry targeted drugs speed up the healing process. In this study, we aimed investigate alginate-grafted N-vinylcaprolactam-based matrix a modified release of dexketoprofen (DEX), which potentially useful Free radical polymerization grafted techniques were used prepare thermo-responsive hydrogels. The obtained hydrogels, unloaded hydrogel (HY) dexketoprofen-loaded (DEXHY), characterized analyzed. concentration DEX encapsulated polymer was 4 mg/mL. IC50 values found samples tested by us 607.4 µg/mL HY, 950.4 DEXHY, 2239 DEX. average value cell viability (%) after exposure cells DEXHY 75.4%. exhibited very good vitro closure rate, given its ability modify kinetics. developed study has shown considerable potential facilitate even accelerate healing, including surgical wounds, inhibiting overexpressed inflammation

Язык: Английский

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Medicinal plants are the basis of natural cosmetics

Process Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Biomaterial-based chitosan nanohydrogel films: combination of Bistorta officinalis and Ca-doped carbon dots for improved blood clotting

Journal of Biological Engineering, Год журнала: 2025, Номер 19(1)

Опубликована: Апрель 10, 2025

Bleeding and traumatic injuries are still a major issue necessitating the development of advanced hemostatic materials that economical, biocompatible, effective. Chitosan's (CS) haemostatic biocompatible properties make it promising wound-healing material, however, effective cross-linking is essential for appropriate physiochemical properties. In this study, calcium-doped carbon dots (CDs) produced from coriander leaves were used as agents to improve functional performance structural integrity nanohydrogel films. Furthermore, extract medicinal plant Bistorta officinalis (BEX), traditional with strong antibacterial qualities, was incorporated into hydrogel matrix. Analysis characterization synthesized CDs thoroughly confirmed they have monodispersed spherical shape, negative zeta potential, active groups which effectively cross-linked chitosan matrix increased mechanical strength stability film. Cytotoxicity results final films showed desired cytocompatibility against Human skin fibroblast (HFF-1 cells) over 80% viability at highest concentration activity gram-positive gram-negative bacteria (further improved by incorporating BEX), respectively. The incorporation BEX in significantly enhanced film's blood-clotting ability negligible hemolysis due blood clotting index tests. findings study highlight potential biomaterial-based nano film, composed CS containing BEX, wound dressing outstanding biocompatibility, minimal cytotoxicity, efficacy,

Язык: Английский

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Natural polysaccharide-based nanodrug delivery systems for targeted treatment of rheumatoid arthritis: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143408 - 143408

Опубликована: Апрель 1, 2025

Язык: Английский

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