World Journal of Methodology,
Год журнала:
2024,
Номер
15(2)
Опубликована: Ноя. 27, 2024
Knee
osteoarthritis
(OA)
is
a
debilitating
condition
with
limited
long-term
treatment
options.
The
therapeutic
potential
of
mesenchymal
stem
cells
(MSCs),
particularly
those
derived
from
bone
marrow
aspirate
concentrate,
has
garnered
attention
for
cartilage
repair
in
OA.
While
the
iliac
crest
traditional
site
harvesting
(BMH),
associated
morbidity
prompted
exploration
alternative
sites
such
as
proximal
tibia,
distal
femur,
and
humerus.
This
paper
reviews
impact
different
on
cell
(MSC)
yield,
viability,
regenerative
potential,
emphasizing
their
relevance
knee
OA
treatment.
consistently
offers
highest
MSC
but
within
surgical
field
procedures
offer
comparable
characteristics
reduced
morbidity.
integration
techniques
into
existing
surgeries,
total
arthroplasty,
provides
less
invasive
approach
while
maintaining
efficacy.
However,
variability
yield
these
underscores
need
further
research
to
standardize
optimize
clinical
outcomes.
Future
directions
include
large-scale
comparative
studies,
advanced
characterization
MSCs,
development
personalized
strategies.
Ultimately,
findings
suggest
that
optimizing
BMH
can
significantly
influence
quality
MSC-based
therapies
OA,
enhancing
utility
patient
Osteoarthritis
(OA)
is
a
degenerative
joint
disease
caused
by
chronic
inflammation
that
damages
articular
cartilage.
In
addition
to
the
wear
and
tear
of
joints,
aberrant
remodelling
driven
significant
presence
inflammatory
mediators
within
one
key
mechanisms
in
pathogenesis
OA.
Among
these
factors,
hyperactivation
Teffs
subsets
plays
crucial
role
promoting
this
pathological
process.
The
immune
imbalance
between
proinflammatory
CD4
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(9), С. 4890 - 4890
Опубликована: Апрель 30, 2024
Glycosphingolipids
(GSLs),
a
subtype
of
glycolipids
containing
sphingosine,
are
critical
components
vertebrate
plasma
membranes,
playing
pivotal
role
in
cellular
signaling
and
interactions.
In
human
articular
cartilage
osteoarthritis
(OA),
GSL
expression
is
known
notably
to
decrease.
This
review
focuses
on
the
roles
gangliosides,
specific
type
GSL,
degeneration
regeneration,
emphasizing
their
regulatory
function
signal
transduction.
The
whether
endogenous
or
augmented
exogenously,
regulated
at
enzymatic
level,
targeting
glycosyltransferases.
regulation
has
significant
implications
for
composition
cell-surface
gangliosides
impact
transduction
chondrocytes
progenitor
cells.
Different
levels
ganglioside
can
influence
pathways
various
ways,
potentially
affecting
cell
properties,
including
malignancy.
Moreover,
gene
manipulations
against
have
been
shown
regulate
metabolisms
chondrocyte
differentiation
vivo
vitro.
highlights
potential
development
therapeutic
strategies
injury
addresses
promising
directions
future
research
treatment.
Tissue Engineering Part B Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 13, 2024
This
research
is
dedicated
to
uncovering
the
evolving
trends,
progressive
developments,
and
principal
themes
in
tissue
engineering
regenerative
medicine
for
rotator
cuff
injuries,
which
spans
past
two
decades.
article
leverages
visualization
methodology
provide
a
clear
comprehensive
portrayal
of
dynamic
landscape
within
field.
We
compiled
758
entries
centered
on
application
treating
drawing
from
Web
Science
Core
Collection
database
covering
period
2003
2023.
Analytical
tools
such
as
VOSviewer,
CiteSpace,
GraphPad
Prism
were
used.
conducted
analyses
discern
general
characteristics,
historical
evolution,
key
literature,
pivotal
keywords
this
analysis
enabled
us
identify
emerging
focal
points
current
trends
addressing
injuries.
The
compilation
articles
study
indicates
consistent
upward
trajectory
publications
concerning
scholarly
contributions
United
States,
China,
South
Korea
have
notable
influence
progression
area.
delineated
ten
specific
subdomains,
including
fatty
infiltration,
tears,
engineering,
shoulder
pain,
tendon
repair,
extracellular
matrix
(ECM),
platelet-rich
plasma
growth
factors.
Noteworthy
recurrent
mention
"mesenchymal
stem
cells,"
"repair,"
"platelet-rich
plasma"
throughout
decades,
highlighting
their
critical
role
evolution
relevant
bibliometric
meticulously
examines
publications,
offering
an
in-depth
exploration
developments
injuries
between
effectively
constructs
knowledge
map,
delineating
contours
domain.
By
pinpointing
prevailing
hotspots,
furnishes
crucial
insights,
setting
direction
forthcoming
explorations
providing
guidance
future
researchers
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2478 - 2478
Опубликована: Окт. 28, 2024
Background/Objectives:
Osteoarthritis
(OA)
is
a
prevalent
and
debilitating
joint
disorder
characterized
by
progressive
cartilage
degradation
inflammation,
for
which
traditional
treatments
offer
only
symptomatic
relief
without
halting
disease
progression.
Exosomes,
cell-free
vesicles
derived
from
mesenchymal
stem
cells,
have
emerged
as
promising
alternative
therapy
owing
to
their
regenerative
anti-inflammatory
properties.
Methods:
This
review
synthesizes
findings
recent
studies
(2017–2023)
on
the
therapeutic
potential
of
exosomes
in
OA
treatment,
highlighting
ability
modulate
microenvironment,
reduce
promote
repair
delivering
bioactive
molecules
such
cytokines,
growth
factors,
regulatory
ribonucleic
acids.
Results:
We
explore
integration
with
biomaterials,
hydrogels
scaffolds,
enhance
delivery
efficacy,
we
address
critical
challenges
associated
clinical
application,
including
standardization
isolation
characterization
methods,
scalability
production,
mechanistic
understanding,
long-term
safety.
Despite
these
challenges,
exosome-based
therapies
several
advantages
over
cell-based
treatments,
lower
immunogenicity,
ease
handling,
targeted
agents
damaged
tissues.
Conclusions:
provide
an
analytical
perspective
current
state
exosome
research
OA,
emphasizing
need
standardized
production
deeper
insights,
rigorous
safety
assessments.
Future
directions
should
focus
optimizing
systems,
exploring
personalized
medicine
approaches,
conducting
comparative
effectiveness
fully
realize
treatment.
Addressing
gaps
will
be
crucial
translating
bench
bedside
achieving
transformative
impact
management.
World Journal of Methodology,
Год журнала:
2024,
Номер
15(2)
Опубликована: Ноя. 27, 2024
Knee
osteoarthritis
(OA)
is
a
debilitating
condition
with
limited
long-term
treatment
options.
The
therapeutic
potential
of
mesenchymal
stem
cells
(MSCs),
particularly
those
derived
from
bone
marrow
aspirate
concentrate,
has
garnered
attention
for
cartilage
repair
in
OA.
While
the
iliac
crest
traditional
site
harvesting
(BMH),
associated
morbidity
prompted
exploration
alternative
sites
such
as
proximal
tibia,
distal
femur,
and
humerus.
This
paper
reviews
impact
different
on
cell
(MSC)
yield,
viability,
regenerative
potential,
emphasizing
their
relevance
knee
OA
treatment.
consistently
offers
highest
MSC
but
within
surgical
field
procedures
offer
comparable
characteristics
reduced
morbidity.
integration
techniques
into
existing
surgeries,
total
arthroplasty,
provides
less
invasive
approach
while
maintaining
efficacy.
However,
variability
yield
these
underscores
need
further
research
to
standardize
optimize
clinical
outcomes.
Future
directions
include
large-scale
comparative
studies,
advanced
characterization
MSCs,
development
personalized
strategies.
Ultimately,
findings
suggest
that
optimizing
BMH
can
significantly
influence
quality
MSC-based
therapies
OA,
enhancing
utility
patient
