Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4271 - 4271
Опубликована: Апрель 30, 2025
The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.
Язык: Английский
Процитировано
2
Pediatric Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Abstract Cell therapies as treatments for neonatal conditions have attracted significant research and parent interest over the last two decades. Mesenchymal stromal cells, umbilical cord blood cells neural stem translate from lab, to preclinical into clinical trials, with contributions being made all world. Effective timely translation involves frequent reflection consultation research-adjacent fields (i.e. cell cerebral palsy, adult neurology, companies, regulatory bodies) well meaningful involvement of people lived experience. Progress date suggests that aligning outcome data reporting in later phase trials will support our sector, involving industry partners streamlined solutions manufacturing, commercialisation processes. Importantly, field can also benefit resource sharing collaboration novel drug therapies, small molecules extracellular vesicles we attempt bridge research. In this review, present highlights learnings second Neonatal Therapies Symposium (2024), held Sydney, Australia. Impact Multiple therapy candidates advanced through neonatology, showing promising feasibility, safety efficacy. is enabled by across fields, commercial partnerships, harmonising outcomes on potential utility further translational considerations are discussed paper.
Язык: Английский
Процитировано
1
Regenerative Engineering and Translational Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
0
Progress in brain research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cell Transplantation, Год журнала: 2025, Номер 34
Опубликована: Март 1, 2025
Although notable progress has been made, restoring motor function from the brain to muscles continues be a substantial clinical challenge in neuron diseases/disorders such as spinal cord injury (SCI). While cell transplantation widely explored potential therapeutic method for reconstructing functional pathways, there remains considerable opportunity enhancing its effectiveness. We reviewed studies on pathway regeneration identify molecular and ultrastructural cues that could enhance efficacy of transplantation. glial scar is often cited an intractable barrier axon regeneration, this mainly applies axons trying penetrate "core" reach opposite side. However, exhibits "duality," with anti-regenerative core pro-regenerative "surface." This surface permissiveness attributed molecules, laminin basement membrane (BM). Transplanting donor cells onto BM, which forms plastically after injury, may significantly Specifically, forming detour pathways between transplanted endogenous propriospinal neurons BM efficiently bypass promote regeneration. believe harnessing tissue's innate repair capacity crucial, targeting post-injury plasticity astrocytes Schwann cells, especially those associated predominantly overlooked field SCI research, can advance system restoration new stage. A shift delivery routes-from traditional intra-parenchymal (InP) route via extra-parenchymal (ExP) route-may signify transformative step forward neuro-regeneration research. Practically, however, complementary use both InP ExP methods offer most benefit pathways. aim review deepen understanding provide framework evaluating modality comparison others.
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 6, 2025
Neurodegenerative diseases including Alzheimer's and Parkinson's disease are age-related disorders which severely impact quality of life impose significant societal burdens. Cellular senescence is a critical factor in these disorders, contributing to their onset progression by promoting permanent cell cycle arrest reducing cellular function, affecting various types cells brain. Recent advancements regenerative medicine have highlighted "R3" strategies-rejuvenation, regeneration, replacement-as promising therapeutic approaches for neurodegeneration. This review aims critically analyze the role neurodegenerative organizes within R3 paradigm. Specifically, we examine stem therapy, direct lineage reprogramming, partial reprogramming context R3, emphasizing how interventions mitigate counteracting aging-related Ultimately, this seeks provide insights into complex interplay between neurodegeneration while highlighting promise cell-based strategies address debilitating conditions.
Язык: Английский
Процитировано
0
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер 139, С. 111375 - 111375
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(5)
Опубликована: Апрель 24, 2025
ABSTRACT From the pioneering days of cell therapy to achievement bioprinting organs, tissue engineering, and regenerative medicine have seen tremendous technological advancements, offering solutions for restoring damaged tissues organs. However, only a few products technologies received United States Food Drug Administration approval. This review highlights significant progress in therapy, extracellular vesicle‐based engineering. Hematopoietic stem transplantation is powerful tool treating many diseases, especially hematological malignancies. Mesenchymal cells been extensively studied. The discovery induced pluripotent has revolutionized disease modeling applications, paving way personalized medicine. Gene represents an innovative approach treatment genetic disorders. Additionally, therapies emerged as rising stars, promising diagnostics, cell‐free therapeutics, drug delivery, targeted therapy. Advances engineering enable complex constructs, further transforming field. Despite these technical, ethical, regulatory challenges remain. addresses current bottlenecks, emphasizing novel interdisciplinary research overcome hurdles. Standardizing practices conducting clinical trials will balance innovation regulation, improving patient outcomes quality life.
Язык: Английский
Процитировано
0
Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Язык: Английский
Процитировано
0