Electrospun Cerium Oxide Nanoparticle/Aloe Vera Extract-Loaded Nanofibrous Poly(Ethylene Oxide)/Polyurethane Mats As Diabetic Wound Dressings

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(8), С. 5268 - 5278

Опубликована: Авг. 2, 2024

Currently the prevalence of diabetic wounds brings a huge encumbrance onto patients, causing high disability and mortality rates major medical challenge for society. Therefore, in this study, we are targeting to fabricate aloe vera extract infused biocompatible nanofibrous patches facilitate process wound healing. Additionally, clindamycin has been adsorbed surface in-house synthesized ceria nanoparticles again used separately design web, as nanoceria can act good drug delivery vehicle exhibit both antimicrobial antidiabetic properties. Various physicochemical characteristics such morphology, porosity, chemical composition produced webs were investigated. Bacterial growth inhibition antibiofilm studies materials confirm its antibacterial efficacy against Gram-positive Gram-negative bacteria. An vitro release study confirmed that mat show sustained pattern (90% 96 h). The web containing loaded not only showed superior performance but also promoted greater contraction (95 ± 2%) diabetes-induced mice just 7 days. Consequently, it efficaciously lowers serum glucose level, inflammatory cytokines, oxidative stress, hepatotoxicity markers endorsed by various ex vivo tests. Conclusively, in-house-fabricated patch potential medicated suppository be treating proximate future.

Язык: Английский

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Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 28, 2024

Impaired wound healing in diabetic individuals creates huge social and financial burdens for both patients the health system. Unfortunately, current treatment has not resulted consistently lower amputation rates. Quinoxalines are heterocyclic compounds with multiple important pharmacological properties. Their effect on have been closely studied. In work, of 3-hydrazinylquinoxaline-2-thiol hydrogel is tested topically a full-thickness excision streptozotocin-induced type 1 rats. We examined closure rate, expression inflammatory factors, growth factors addition to histological analysis. The results revealed significant acceleration treated group compared control experimental animals. Histological data demonstrated enhanced re-epithelialization collagen disposition. was additionally evaluated by inhibition response interleukin (IL)-1β (IL)-6, tumor necrosis factor (TNF-α) nuclear kappa-light-chain-enhancer activated B cells (NF-κB) marked improvement transforming beta (TGFβ-1), antioxidant markers collagen-1. silico study indicated favorable drug-like properties toxicity profile. present work showed that holds great potential wounds.

Язык: Английский

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Functional electrospinning Janus dressings with asymmetric surface wettability

Applied Materials Today, Год журнала: 2024, Номер 41, С. 102445 - 102445

Опубликована: Сен. 30, 2024

Язык: Английский

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Network Pharmacology, Molecular Docking and Experimental Validation on Potential Application of Diabetic Wound Healing of Cinnamomum zeylanicum Through Matrix Metalloproteinases-8 And 9 (MMP-8 And MMP-9)

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 1753 - 1782

Опубликована: Март 1, 2025

Background: Diabetic wounds are a significant clinical challenge due to impaired healing processes often exacerbated by elevated matrix metalloproteinases (MMPs). Cinnamomum zeylanicum , known for its anti-inflammatory and antioxidant properties, has shown potential in promoting wound healing. This study investigates the molecular docking experimental validation of 's effects on diabetic healing, focusing interaction with metalloproteinases-8 (MMP-8) 9 (MMP-9). Methods: Molecular studies were performed predict binding affinity compounds MMP-8 MMP-9. was evaluated using vivo models where induced treated extract. Various parameters measured, including contraction, hydroxyproline content, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) levels. Biochemical analyses included glucose levels, fasting blood (FBG), oral tolerance test (OGTT), histomorphological examination skin tissues. Results: results indicated high zeylanicum's bioactive MMP-9, suggesting inhibition. Experimental showed improvement contraction increased indicating enhanced collagen synthesis. Antioxidant enzyme activities (SOD, GPx, CAT) significantly elevated, while MDA levels reduced, reflecting decreased oxidative stress. analysis demonstrated improved homeostasis reduced FBG OGTT responses. Histomorphological revealed tissue architecture re-epithelialization wounds. Conclusion: exhibits promising modulating MMP-9 activities, enhancing defenses, improving regulation. These findings support therapeutic application wounds, providing foundation further investigations. Keywords: xanthosine, methylquinoline, metalloproteinase,

Язык: Английский

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A thermosensitive chitosan hydrogel loaded with Thonningianin A nanoparticles promotes diabetic wound healing by modulating oxidative stress and angiogenesis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143136 - 143136

Опубликована: Апрель 1, 2025

Язык: Английский

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