Optimisation of Photo‐Curable 3D‐Printed Bionic Double Layer Lower Extremity Vascular Models Based on Biomechanical Performance Evaluation

Biosurface and Biotribology, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 1, 2025

ABSTRACT Guidewire interventional radiotherapy is an important means for the diagnosis and treatment of cardiovascular disease, risk intraoperative guidewire puncture jeopardises life health patients. A bionic multilayer vascular model that conforms to real morphology mechanical properties arterial vessels can help surgeons familiarise themselves with blood in preoperative simulations thus avoid puncture. In this paper, porcine abdominal aortic were used as a biological evaluate its by T‐peel test, uniaxial tensile test force test. The results showed average delamination between intima media was 1.11 N. radial strength greater than axial elongation at break increased after peeling intima. manufacturing method developed, structural integrity improved using intima–media nesting method. This research provides guidance material selection preparation processes 3D printed lower limb models contributes development more accurate functional biomedical applications.

Язык: Английский

From Biomechanical Properties to Morphological Variations: Exploring the Interplay between Aortic Valve Cuspidity and Ascending Aortic Aneurysm

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(14), С. 4225 - 4225

Опубликована: Июль 19, 2024

Background: This research explores the biomechanical and structural characteristics of ascending thoracic aortic aneurysms (ATAAs), focusing on differences between bicuspid valve (BAV-As) tricuspid (TAV-As) with non-dilated aortas to identify specific traits ATAAs. Methods: Clinical characteristics, laboratory indices, imaging data from 26 adult patients operated for (BAV-A: n = 12; TAV-A: 14) 13 controls were analyzed. Biomechanical parameters (maximal diameter, strain, stress) analyses (collagen fiber organization, density, fragmentation, adipocyte deposits, immune cell infiltration) assessed. Results: Significant in observed. Median maximal strain was 40.0% (control), 63.4% (BAV-A), 45.3% (TAV-A); median stress 0.59 MPa 0.78 0.48 (TAV-A). BAV-A showed higher tangential modulus smaller substantial collagen fragmentation (p < 0.001 vs. TAV controls). TAV-A exhibited increased density 0.025), thickening media adventitia layers, disorganized fibers 0.036). had elevated deposits infiltration. Conclusions: study highlights distinct pathological profiles associated different anatomies. is characterized by diameters, stress, significant deterioration, underscoring necessity tailored clinical strategies effective management aneurysm.

Язык: Английский