Innovative theranostic hydrogels for targeted gastrointestinal cancer treatment
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 27, 2024
Gastrointestinal
tumors
are
the
main
causes
of
death
among
patients.
These
mainly
diagnosed
in
advanced
stages
and
their
response
to
therapy
is
unfavorable.
In
spite
development
conventional
therapeutics
including
surgery,
chemotherapy,
radiotherapy
immunotherapy,
treatment
these
still
challenging.
As
a
result,
new
based
on
(nano)biotechnology
have
been
introduced.
Hydrogels
polymeric
3D
networks
capable
absorbing
water
swell
with
favorable
biocompatibility.
application
hydrogels
different
human
diseases,
wide
cancer
has
improved
because
potential
drug
gene
delivery,
boosting
chemotherapy
immunotherapy
as
well
vaccines.
The
current
review
focuses
role
gastrointestinal
tumors.
provide
delivery
drugs
(both
natural
or
synthetic
compounds
co-delivery)
along
delivery.
Along
stimulate
phototherapy
(photothermal
photodynamic
therapy)
suppression
Besides,
ability
for
induction
immune-related
cells
such
dendritic
can
boost
immunotherapy.
For
more
specific
therapy,
stimuli-responsive
types
thermo-
pH-sensitive
self-healing
site
Moreover,
promising
diagnosis,
circulating
tumor
cell
isolation
detection
biomarkers
tumors,
highlighting
importance
clinic.
Hence,
diagnostic
therapeutic
tools
gastrointestimal
Язык: Английский
Traditional Chinese medicine and its components effectively reduce resistance mediated by immune checkpoint inhibitors
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 26, 2024
Immunotherapy
has
become
a
global
focus
in
cancer
treatment
and
research,
with
promising
results
from
targeting
immune
checkpoints
tumors
like
non-small
cell
lung
cancer,
colon
melanoma.
However,
resistance
to
checkpoint
inhibitors
(ICIs)
remains
significant
challenge.
Traditional
Chinese
medicine
(TCM),
known
for
its
low
toxicity
minimal
side
effects,
shows
promise
enhancing
when
combined
modern
therapies.
This
study
reviews
recent
research
on
ICIs
mechanisms
highlights
TCM's
potential
overcoming
this
resistance,
aiming
improve
efficacy
while
minimizing
toxicity.
Язык: Английский