Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone DOI Creative Commons
Yongheng Zhang,

Lvhua Liu,

Mengqi Li

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, biocompatibility. However, inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts clinical adoption. Herein, strontium (Sr) incorporated onto the surface of PEEK using mussel-inspired polydopamine coating improve activity. X-ray photoelectron spectroscopy ion release assay results confirm that different concentrations Sr are substrate surfaces. The strontium-modified samples show a stable 35 days detection. Better MC3T3-E1 pre-osteoblasts adhesion, spreading, proliferation can be observed groups, demonstrates with improved compatibility. boosted activity has been demonstrated by better performed ALP extracellular matrix mineralization, collagen secretion, remarkable up-regulation ALP, OCN, OPN, Runx2, Col-I, BSP, OSX pre-osteoblasts. Additionally, exhibit dose-dependent enhancement osteoblasts compatibility PEEK-Sr10 group shows best. These findings indicate strontium-decorated promising application implants.

Язык: Английский

The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes DOI Creative Commons
Yanru Ren, Said Alkildani,

Kim Burckhardt

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12

Опубликована: Янв. 6, 2025

This study investigates the mechanical properties as well in vitro and vivo cyto- biocompatibility of collagen membranes cross-linked with glutaraldehyde (GA), proanthocyanidins (PC), hexamethylendiisocyanate (HMDI) 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EC/NHS). A non-crosslinked membrane was used reference control (RF). The initial cytotoxic analyses revealed that PC, EC, HMDI crosslinked were cytocompatible, while GA thus selected positive further study. Cross-linking enhances tensile strength collagenase resistance, effectively prolonging membrane's standing time vivo. Using (immune-) histochemistry histomorphometrical analyses, cellular inflammatory responses, tissue integration vascularization patterns at 10-, 30-, 90-day post-implantation a subcutaneous implantation model rats analyzed. PC elicited mildest cell levels, akin to RF membrane, other groups induced an M1-dominated macrophage response numerous multinucleated giant cells throughout period. EC maintained structural stability up 30 days post-implantation, similar group, whereas others collapsed prematurely. Concurrent collapse, transmembrane occurred across all groups. Histopathological histomorphometry results reveal intricate interplay populations vascularization. These findings offer valuable insights into pivotal role cross-linkers modulating responses membranes.

Язык: Английский

Процитировано

1

Fabrication and characterization of hydroxyapatite substituted with Mg2+, Sr2+, and ampicillin for bone and antibacterial applications DOI

Venkatachalam Murugesan,

Arulkumar Murugeasan,

Sivarasan Ganesan

и другие.

Materials Science and Engineering B, Год журнала: 2025, Номер 316, С. 118131 - 118131

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

1

Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone DOI Creative Commons
Yongheng Zhang,

Lvhua Liu,

Mengqi Li

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, biocompatibility. However, inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts clinical adoption. Herein, strontium (Sr) incorporated onto the surface of PEEK using mussel-inspired polydopamine coating improve activity. X-ray photoelectron spectroscopy ion release assay results confirm that different concentrations Sr are substrate surfaces. The strontium-modified samples show a stable 35 days detection. Better MC3T3-E1 pre-osteoblasts adhesion, spreading, proliferation can be observed groups, demonstrates with improved compatibility. boosted activity has been demonstrated by better performed ALP extracellular matrix mineralization, collagen secretion, remarkable up-regulation ALP, OCN, OPN, Runx2, Col-I, BSP, OSX pre-osteoblasts. Additionally, exhibit dose-dependent enhancement osteoblasts compatibility PEEK-Sr10 group shows best. These findings indicate strontium-decorated promising application implants.

Язык: Английский

Процитировано

0