Partitioning Behavior of Anti-Inflammatory Drugs Using Aqueous Two-Phase Systems Based on Green Betaine Ionic Liquids
Journal of Chemical & Engineering Data,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Anti-inflammatory
medications
such
as
salicylic
acid
and
acetaminophen
are
the
most
prescribed
drugs
in
world
that
could
be
found
wastewater.
Separation
of
these
from
aqueous
media
has
an
economic
environmental
impact.
Recently,
there
been
considerable
interest
utilizing
two-phase
systems
(ATPSs)
containing
biocompatible
ionic
liquids
(ILs)
for
extraction
various
substances
due
to
their
low
cost
easy
formation,
while
finding
green
materials
form
is
challenging.
Therefore,
this
work,
phase
diagram
novel
ATPSs
composed
two
betaine-based
ILs,
betaine
hexyl
ester
bromide
[BH]Br
octyl
[BO]Br,
phosphate
salts
(K3PO4
K2HPO4)
have
investigated
at
298.15
K
atmospheric
pressure
(≈85
kPa).
The
experimental
binodal
data
were
correlated
by
using
empirical
nonlinear
three-parameter
expression
developed
Merchuk.
Then,
Setschenow-type
equation
NRTL
model
employed
establish
correlations
tie-lines.
Finally,
ATPSs,
partition
behavior
was
measuring
coefficient
efficiency.
results
showed
selected
successfully
extracted
into
IL-rich
top
studied
with
coefficients
greater
than
one
across
different
Язык: Английский
Exploring the Biological Activities of Ionic Liquids and Their Potential to Develop Novel Vaccine Adjuvants
Vaccines,
Год журнала:
2025,
Номер
13(4), С. 365 - 365
Опубликована: Март 28, 2025
Ionic
liquids
(ILs)
are
salts
with
poorly
coordinated
ions,
allowing
them
to
exist
in
a
liquid
phase
below
100
°C
or
at
room
temperature.
Therefore,
they
best
described
as
temperature
ionic
(RTILs).
In
liquids,
the
presence
of
delocalized
charge
least
one
ion,
coupled
an
organic
component,
inhibits
establishment
stable
solid
crystal
lattice.
Due
their
flexible
properties
and
several
distinctive
characteristics,
such
high
conductivity,
solvation
power,
thermal
stability,
low
volatility,
recyclability,
ILs
have
been
extensively
used
chemical
industries.
addition
various
other
applications,
also
hold
potential
for
drug
formulation
development.
can
be
solubility
enhancers,
permeability
stabilizers,
targeted
delivery
inducers,
stealth
property
providers,
bioavailability
enhancers.
Moreover,
significant
vaccine
formulation.
Many
new
vaccines
pipeline
different
types
antigens;
however,
existence
only
limited
number
adjuvants
hinder
use.
Thus,
developing
new,
highly
effective,
low-cost
adjuvant
preparations
is
central
interest
among
scientists.
With
unique
biological
functions,
promising
candidates
vaccines.
Язык: Английский
Patents, clinical trials, and regulatory concerns with stimuli-responsive vesicular carriers
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 409 - 425
Опубликована: Янв. 1, 2025
Язык: Английский
Sustainable ionic liquid design for enhanced solubility and safety of Tamoxifen: A computational exploration
Sustainable Chemistry and Pharmacy,
Год журнала:
2025,
Номер
45, С. 102046 - 102046
Опубликована: Май 13, 2025
Язык: Английский
Leveraging Numerical Simulation Technology to Advance Drug Preparation: A Comprehensive Review of Application Scenarios and Cases
Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1304 - 1304
Опубликована: Окт. 7, 2024
Numerical
simulation
plays
an
important
role
in
pharmaceutical
preparation
recently.
Mechanistic
models,
as
a
type
of
numerical
model,
are
widely
used
the
study
preparations.
models
based
on
priori
knowledge,
i.e.,
laws
physics,
chemistry,
and
biology.
However,
due
to
interdisciplinary
reasons,
pharmacy
researchers
have
greater
difficulties
using
computer
models.
Язык: Английский