Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 5, 2025
Traumatic
brain
injury
(TBI)
disrupts
oxygen
homeostasis
in
the
brain,
leading
to
excessive
reactive
species
(ROS)
production
and
dysregulated
antioxidant
mechanisms,
which
fail
clear
excess
ROS.
This
ROS
overload
promotes
expression
of
pro-inflammatory
genes,
releasing
cytokines
chemokines
creating
a
vicious
"ROS-neuroinflammation"
cycle,
making
it
essential
break
this
cycle
for
effective
TBI
treatment.
In
study,
we
developed
cysteine-alanine-glutamine-lysine
(CAQK)
peptide-modified
nanoparticles
(C-PPS/C)
co-delivery
curcumin
(Cur)
modulate
oxidative
neuroinflammatory
disturbances
after
TBI.
mice,
C-PPS/C
accumulated
injured
regions,
where
poly
(propylene
sulfide)120
scavenged
ROS,
reducing
stress,
while
Cur
release
further
suppressed
inflammation.
broke
protecting
blood-brain
barrier
(BBB),
acute
edema,
promoting
long-term
neurological
recovery.
Further
investigation
showed
that
inhibited
NF-κB
pathway,
gene
mitigating
inflammation,
suggesting
promising
approach
Язык: Английский
Applications of Hydrogels in Emergency Therapy
Gels,
Год журнала:
2025,
Номер
11(4), С. 234 - 234
Опубликована: Март 23, 2025
Interest
in
developing
new,
effective
materials
for
emergency
hemostasis
and
wound
healing
is
steadily
increasing,
particularly
use
emergency,
surgical,
military
situations.
Hydrogels,
with
their
unique
retention,
swelling,
biocompatibility
properties,
have
emerged
as
essential
therapy.
This
review
provides
a
comprehensive
examination
of
recent
hydrogel
applications
acute
medical
scenarios,
including
hemostasis,
management,
drug
delivery,
soft
tissue
replacement,
engineering.
We
discuss
the
physicochemical
properties
that
make
hydrogels
suitable
rapid
response
situations,
such
tunable
mechanical
strength,
adhesiveness,
responsiveness
to
environmental
stimuli,
ability
encapsulate
release
therapeutic
agents.
Additionally,
article
explores
advancements
smart
self-healing
antimicrobial
providing
insights
into
potential
revolutionize
care
increase
survival
rates
both
civilian
applications.
Through
critical
evaluation
current
clinical
trials
practical
deployments,
this
highlights
successes
challenges
faced
integrating
protocols,
roadmap
future
research
development
dynamic
field.
Язык: Английский