Engineering Useful Microbial Species for Pharmaceutical Applications
Microorganisms,
Год журнала:
2025,
Номер
13(3), С. 599 - 599
Опубликована: Март 5, 2025
Microbial
engineering
has
made
a
significant
breakthrough
in
pharmaceutical
biotechnology,
greatly
expanding
the
production
of
biologically
active
compounds,
therapeutic
proteins,
and
novel
drug
candidates.
Recent
advancements
genetic
engineering,
synthetic
biology,
adaptive
evolution
have
contributed
to
optimization
microbial
strains
for
applications,
playing
crucial
role
enhancing
their
productivity
stability.
The
CRISPR-Cas
system
is
widely
utilized
as
precise
genome
modification
tool,
enabling
enhancement
metabolite
biosynthesis
activation
biological
pathways.
Additionally,
biology
approaches
allow
targeted
design
microorganisms
with
improved
metabolic
efficiency
potential,
thereby
accelerating
development
new
products.
integration
artificial
intelligence
(AI)
machine
learning
(ML)
plays
vital
further
advancing
by
predicting
network
interactions,
optimizing
bioprocesses,
discovery
process.
However,
challenges
such
efficient
pathways,
ensuring
sustainable
industrial-scale
production,
meeting
international
regulatory
requirements
remain
critical
barriers
field.
Furthermore,
mitigate
potential
risks,
it
essential
develop
stringent
biocontainment
strategies
implement
appropriate
oversight.
This
review
comprehensively
examines
recent
innovations
analyzing
key
technological
advancements,
challenges,
future
perspectives.
Язык: Английский
The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 54
Опубликована: Апрель 5, 2025
Cancer
is
a
leading
cause
of
mortality
and
morbidity
worldwide.
Nanomaterials,
unique
optical,
magnetic,
electrical
properties
at
the
nanoscale
(1-100
nm),
have
been
engineered
to
improve
drug
capacity,
bioavailability,
specificity
in
cancer
treatment.
These
advancements
address
toxicity
lack
selectivity
conventional
therapies,
enabling
precise
targeting
cells,
tumor
microenvironment,
immune
system.
Among
emerging
approaches,
bacterial
treatment
shows
promise
due
its
natural
ability
target
diverse
therapeutic
mechanisms,
which
nanotechnology
can
further
enhance.
Bacteria-based
delivery
systems
leverage
bacteria's
adaptability
survival
strategies
within
human
body.
Bacterial
derivatives,
such
as
ghosts
(BGs),
extracellular
vesicles
(BEVs),
dietary
toxins,
are
recognized
effective
biological
nanomaterials
capable
carrying
nanoparticles
(NPs).
attracted
increasing
attention
for
their
potential
targeted
NP
This
study
explores
use
various
bacteria
byproducts
vehicles,
highlighting
treating
different
types
cancer.
By
combining
strengths
therapy,
these
innovative
approaches
aim
revolutionize
with
improved
precision
efficacy.
Язык: Английский