Nigerian Journal of Experimental and Clinical Biosciences,
Год журнала:
2021,
Номер
9(4), С. 250 - 262
Опубликована: Окт. 1, 2021
Background:
The
increased
prevalence
of
uterine
fibroid
(UF)
and
its
life-threatening
impact
among
women
reproductive
age
led
to
the
development
this
study.
study
investigated
antifibrotic
potential
Tetracarpidium
conophorum
aqueous
extract
on
UF-induced
rats.
Materials
Methods:
Sixty-four
female
Wistar
rats,
with
an
average
weight
200
g,
were
used
for
rats
randomly
divided
into
eight
groups
animals
each.
UF
was
induced
by
oral
administration
diethylstilbestrol
(DES)
intramuscular
injection
progesterone
at
dosages
1.35
1.0
mg/kg
body
weight,
respectively.
Group
1
administered
normal
saline
orally
8
weeks.
Groups
2
3
treated
a
combination
DES
progesterone,
4
5
pretreated
400
T.
extract,
respectively,
weeks
before
6
7
being
self-recovery
group-administered
after
which
they
given
Results:
After
treatment
period,
euthanized,
blood
collected,
while
uteruses
harvested.
Co-administration
produces
conditions.
However,
pre-
post-treatment
mitigated
effects
that
but
no
remarkable
preventive
curative
observed
higher
dosage
(400
mg/kg).
There
reduction
serum
prolactin
level
in
posttreatment
group.
Conclusion:
has
shown
both
low
(200
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(10), С. 5772 - 5772
Опубликована: Май 21, 2022
The
transient
receptor
potential
vanilloid
1
(TRPV1)
ion
channel
plays
an
important
role
in
the
peripheral
nociceptive
pathway.
TRPV1
is
a
polymodal
that
can
be
activated
by
multiple
types
of
ligands
and
painful
stimuli,
such
as
noxious
heat
protons,
contributes
to
various
acute
chronic
pain
conditions.
Therefore,
emerging
novel
therapeutic
target
for
treatment
Notably,
peptides
isolated
from
venomous
animals
potently
selectively
control
activation
inhibition
binding
its
outer
pore
region.
This
review
will
focus
on
mechanisms
which
venom-derived
interact
with
this
portion
functions
how
these
drive
development
new
analgesics.
Neuroscience,
Год журнала:
2022,
Номер
518, С. 112 - 118
Опубликована: Апрель 23, 2022
Disruption
of
calcium
(Ca2+)
homeostasis
is
emerging
as
a
prevalent
feature
aging
and
aging-associated
neurodegenerative
diseases,
including
Alzheimer's
disease
(AD),
the
most
common
type
tauopathy.
This
characterized
by
combined
presence
extracellular
neuritic
plaques
composed
amyloid
β-peptides
(Aβ)
neurofibrillary
tangles
tau.
The
association
dyshomeostasis
with
Aβ
has
been
extensively
studied,
however
its
link
tau
less
investigated.
Thus,
this
review
will
concentrate
on
functional
between
plasma
membrane
Ca2+
pump
(PMCA)
other
proteins
involved
in
regulation
intracellular
and/or
neurodegeneration.
Journal of Histochemistry & Cytochemistry,
Год журнала:
2024,
Номер
72(4), С. 199 - 231
Опубликована: Апрель 1, 2024
The
large
family
of
transient
receptor
potential
(TRP)
channels
are
integral
membrane
proteins
that
function
as
environmental
sensors
and
act
ion
after
activation
by
mechanical
(touch),
physical
(heat,
pain),
chemical
stimuli
(pungent
compounds
such
capsaicin).
Most
TRP
localized
in
the
plasma
cells
but
some
them
membranes
organelles
intracellular
Ca
2+
-ion
channels.
involved
neurological
disorders
their
precise
role(s)
relevance
these
not
clear.
Endothelial
blood–brain
barrier
(BBB)
express
vanilloid
1–4
thermal
detection
regulating
BBB
permeability.
In
disorders,
responsible
for
edema
formation
brain.
Therefore,
drug
design
to
modulate
locally
activity
is
a
hot
topic.
Today,
application
channel
antagonists
against
still
limited.
Briefings in Bioinformatics,
Год журнала:
2023,
Номер
24(4)
Опубликована: Июнь 15, 2023
Untargeted
metabolomics
is
gaining
widespread
applications.
The
key
aspects
of
the
data
analysis
include
modeling
complex
activities
metabolic
network,
selecting
metabolites
associated
with
clinical
outcome
and
finding
critical
pathways
to
reveal
biological
mechanisms.
One
roadblocks
in
not
well-addressed,
which
problem
matching
uncertainty
between
features
known
metabolites.
Given
limitations
experimental
technology,
identities
cannot
be
directly
revealed
data.
predominant
approach
for
mapping
match
mass-to-charge
ratio
(m/z)
those
derived
from
theoretical
values
relationship
one-to-one
since
some
share
molecular
composition,
various
adduct
ions
can
same
metabolite.
This
causes
unreliable
metabolite
selection
functional
results.
Here
we
introduce
an
integrated
deep
learning
framework
that
take
into
consideration.
model
devised
a
gradual
sparsification
neural
network
based
on
annotation
architecture
characterizes
reflects
modular
structure
system.
Three
goals
achieved
simultaneously
without
requiring
much
inference
additional
assumptions:
(1)
evaluate
importance,
(2)
infer
feature-metabolite
likelihood
(3)
select
disease
sub-networks.
When
applied
COVID
dataset
aging
mouse
brain
dataset,
our
method
found
sub-networks
were
easily
interpretable.
AJP Cell Physiology,
Год журнала:
2024,
Номер
327(6), С. C1384 - C1399
Опубликована: Окт. 14, 2024
After
the
initial
concepts
of
constancy
internal
milieu
or
homeostasis,
put
forward
by
Claude
Bernard
and
Walter
Cannon,
homeostasis
emerged
as
a
mechanism
to
control
oscillations
biologically
meaningful
variables
within
narrow
physiological
ranges.
This
is
primary
need
in
central
nervous
system
that
continuously
subjected
multitude
stimuli
from
external
environments
affect
its
function
structure,
allowing
adapt
individual
ever-changing
daily
conditions.
Preserving
levels
activity
despite
disturbances
could
either
depress
neural
computation
excessively
stimulate
fundamental,
failure
these
homeostatic
mechanisms
can
lead
brain
diseases.
In
this
review,
we
cover
role
main
plasticity
involving
regulation
excitability
synaptic
strength
single
neuron
network
level.
We
analyze
relationships
between
Hebbian
conditions
under
which
preservation
excitatory/inhibitory
balance
fails,
triggering
epileptogenesis
eventually
epilepsy.
Several
therapeutic
strategies
cure
epilepsy
have
been
designed
strengthen
when
endogenous
become
insufficient
ineffective
contrast
hyperactivity.
describe
“on
demand”
gene
therapy
strategies,
including
optogenetics,
chemogenetics,
chemo-optogenetics,
particularly
focus
on
new
closed
loop
sensor-actuator
mimicking
be
endogenously
expressed
defenses
against
The Anatomical Record,
Год журнала:
2022,
Номер
306(9), С. 2264 - 2275
Опубликована: Июнь 19, 2022
Abstract
Along
with
well‐known
data
on
the
neurochemical
mechanisms
of
nociceptor
activation,
there
are
still
no
clear
regarding
changes
in
cellular
composition
and
morphological
characteristics
spinal
preganglionic
neurons
(SPN)
after
capsaicin
treatment.
The
mechanism
toxicity
differs
developing
mature
nerve
cells.
This
study
aimed
to
determine
number
SPN
autonomic
nuclei
cord
(SC)
sections
their
cross‐sectional
area,
localization,
percentage,
profile
area
containing
neuronal
nitric
oxide
synthase
(nNOS)
calbindin
(CB)
thoracic
SC
rats
different
ages
(from
birth
1‐year‐old)
Neonatal
treatment
generally
decreased
pericarya.
However,
CB‐immunoreactive
(IR)
increased
central
aged
10–30
days
old
only
<20
days.
proportion
nNOS‐IR
remained
steady
did
not
change
during
development.
capsaicin‐treated
was
less
than
that
control
rats.
results
obtained
will
promote
further
studies
sensory
processing
development
sympathetic
nervous
system.
Nigerian Journal of Experimental and Clinical Biosciences,
Год журнала:
2021,
Номер
9(4), С. 250 - 262
Опубликована: Окт. 1, 2021
Background:
The
increased
prevalence
of
uterine
fibroid
(UF)
and
its
life-threatening
impact
among
women
reproductive
age
led
to
the
development
this
study.
study
investigated
antifibrotic
potential
Tetracarpidium
conophorum
aqueous
extract
on
UF-induced
rats.
Materials
Methods:
Sixty-four
female
Wistar
rats,
with
an
average
weight
200
g,
were
used
for
rats
randomly
divided
into
eight
groups
animals
each.
UF
was
induced
by
oral
administration
diethylstilbestrol
(DES)
intramuscular
injection
progesterone
at
dosages
1.35
1.0
mg/kg
body
weight,
respectively.
Group
1
administered
normal
saline
orally
8
weeks.
Groups
2
3
treated
a
combination
DES
progesterone,
4
5
pretreated
400
T.
extract,
respectively,
weeks
before
6
7
being
self-recovery
group-administered
after
which
they
given
Results:
After
treatment
period,
euthanized,
blood
collected,
while
uteruses
harvested.
Co-administration
produces
conditions.
However,
pre-
post-treatment
mitigated
effects
that
but
no
remarkable
preventive
curative
observed
higher
dosage
(400
mg/kg).
There
reduction
serum
prolactin
level
in
posttreatment
group.
Conclusion:
has
shown
both
low
(200
