Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(22), С. 6753 - 6753
Опубликована: Ноя. 15, 2022
(1)
Background:
Controversial
conclusions
have
been
made
in
previous
studies
regarding
the
influence
of
autologous
platelet-rich
plasma
(PRP)
reproductive
outcomes
women
with
repeated
implantation
failures
(RIF)
who
are
undergoing
embryo
transfer
(ET).
(2)
Methods:
This
study
aimed
to
evaluate
effect
PRP
intrauterine
infusion
patients
unexplained
RIF,
vitro
fertilization
(IVF)
or
intracytoplasmic
injection
(ICSI),
by
a
systematic
review
and
meta-analysis.
(3)
Results:
A
fixed-effects
model
was
used,
795
cases
834
controls
were
included
these
studies.
The
pooling
results
showed
beneficial
which
compared
those
control
terms
clinical
pregnancy
rates
(n
=
10,
risk
ratio
(RR)
1.79,
95%
confidence
intervals
(CI):
1.55,
2.06;
p
<
0.01,
I2
40%),
live
birth
4,
RR
2.92,
CI:
2.22,
3.85;
83%),
3,
1.74,
1.34,
2.26;
0%),
positive
serum
β-HCG
14
days
after
ET
8,
1.77,
1.54,
2.03;
36%).
However,
we
did
not
find
that
miscarriage
indicated
significant
difference
between
two
groups
6,
1.04,
0.72,
1.51;
0.83,
0%).
(4)
Conclusions:
findings
this
systemic
meta-analysis
suggest
appears
improve
IVF/ICSI
treatments
RIF.
Implantation
success
relies
on
intricate
interplay
between
the
developing
embryo
and
maternal
endometrium.
Extracellular
vesicles
(EVs)
represent
an
important
player
of
this
intercellular
signalling
through
delivery
functional
cargo
(proteins
RNAs)
that
reprogram
target
cells
protein
RNA
landscape.
Functionally,
reciprocity
endometrial
EVs
regulates
site
implantation,
preimplantation
development
hatching,
antioxidative
activity,
attachment,
trophoblast
invasion,
arterial
remodelling,
immune
tolerance.
Omics
technologies
including
mass
spectrometry
have
been
instrumental
in
dissecting
EV
regulate
these
processes
as
well
molecular
changes
endometrium
to
facilitate
implantation.
This
has
also
led
discovery
potential
human
uterine
fluid
(UF)
spent
media
(ESM)
diagnostic
therapeutic
value
implantation
success,
fertility,
pregnancy
outcome.
review
discusses
contribution
hallmarks
how
integration
various
omics
is
enabling
design
EV-based
platforms
reproductive
medicine.
Diagnostics,
Год журнала:
2022,
Номер
12(11), С. 2611 - 2611
Опубликована: Окт. 27, 2022
Despite
the
advances
in
field
of
reproductive
medicine,
implantation
failure
represents
a
challenging
condition
affecting
10–30%
patients
subjected
to
vitro
fertilization
(IVF).
Research
has
focused
on
identification
molecules
playing
crucial
roles
endometrial
receptivity,
with
aim
designing
predictive
tools
for
efficient
detection
window.
To
that
end,
novel
molecular
genomic
and
transcriptomic
approaches
have
been
introduced
as
promising
enable
personalized
optimizing
embryo
transfer
dating.
However,
clinical
value
these
remains
unclear.
The
this
study
is
provide
systematic
review
critical
analysis
existing
evidence
regarding
employment
commercially
available
evaluate
receptivity.
An
Embase
PubMed/Medline
search
was
performed
1
February
2022.
From
475
articles
yielded,
only
27
were
included
analyzed.
considerable
heterogeneity
indicates
uniqueness
window,
showcasing
optimal
time
varies
significantly
between
women.
Moreover,
provides
information
technical
aspects
advanced
tools,
well
an
possible
biomarkers
providing
basis
future
research
field.
Biologia Futura,
Год журнала:
2022,
Номер
73(3), С. 291 - 300
Опубликована: Сен. 1, 2022
Abstract
The
existence
of
Lactobacillus-led
colonized
bacteria
in
the
endometrium
a
healthy
human
has
been
reported
recent
studies.
Unlike
composition
microbiome
lower
genital
tract,
that
is
different
and
closely
associated
with
physiological
pathological
processes
gynecological
diseases.
For
example,
changing
immune
microenvironment
affects
receptivity
endometrium,
thereby
leading
to
abnormal
reproductive
outcomes,
such
as
embryo
implantation
failure
recurrent
spontaneous
abortion.
However,
concrete
functions
mechanisms
endometrial
have
not
studied
thoroughly.
This
review
elaborates
research
progress
on
by
which
from
perspective
regulation.
Considering
lack
unified
evaluation
method
for
microbiome,
well
an
optimal
treatment
protocol
against
abortion,
we
also
discussed
application
combining
antibiotics
probiotics/prebiotics
precautionary
measures.
Reproductive Biology and Endocrinology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Авг. 19, 2022
Abstract
Background
Patients
with
recurrent
implantation
failure
(RIF)
may
have
more
uterine
contractions.
Several
observational
studies
suggested
that
atosiban
administration
around
embryo
transfer
resulted
in
higher
pregnancy
rates
RIF
patients.
This
study
aimed
to
evaluate
the
effect
of
given
before
fresh
on
outcomes
women
RIF.
Methods
A
prospective,
randomized,
double-blind
controlled
clinical
trial
was
performed
IVF
center
Shanghai
First
Maternity
and
Infant
Hospital.
According
a
computer-generated
randomization
list,
194
infertile
received
between
July
2017
December
2019
were
randomly
allocated
into
(
n
=
97)
placebo
groups.
Women
treatment
group
intravenously
about
30
min
bolus
dose
6.75
mg
over
one
minute.
Those
only
normal
saline
infusion
for
same
duration.
Results
There
no
significant
difference
live
birth
rate
groups
(42.3%
vs
35.1%,
P
0.302,
RR
1.206
(0.844–1.723)).
No
differences
found
two
positive
test,
pregnancy,
ongoing
miscarriage,
multiple
ectopic
rates.
Similar
results
when
stratified
by
number
embryos
previously
transferred,
previous
failed
transfers,
frequency
endometrial
peristalsis
day
(≥
3
waves/min)
or
serum
estradiol
(E
2
)
hCG
above
median
level.
And,
there
correlation
E
level
day.
The
day,
total
FSH/HMG
dosage
duration
factors
which
independently
predicted
likelihood
birth.
Conclusions
These
might
not
improve
Trial
registration
had
been
approved
Institutional
Review
Board
hospital
(2017
ethics
No.43)
registered
under
Clinicaltrials.gov
an
identifier
NCT02893722.
Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(22), С. 6753 - 6753
Опубликована: Ноя. 15, 2022
(1)
Background:
Controversial
conclusions
have
been
made
in
previous
studies
regarding
the
influence
of
autologous
platelet-rich
plasma
(PRP)
reproductive
outcomes
women
with
repeated
implantation
failures
(RIF)
who
are
undergoing
embryo
transfer
(ET).
(2)
Methods:
This
study
aimed
to
evaluate
effect
PRP
intrauterine
infusion
patients
unexplained
RIF,
vitro
fertilization
(IVF)
or
intracytoplasmic
injection
(ICSI),
by
a
systematic
review
and
meta-analysis.
(3)
Results:
A
fixed-effects
model
was
used,
795
cases
834
controls
were
included
these
studies.
The
pooling
results
showed
beneficial
which
compared
those
control
terms
clinical
pregnancy
rates
(n
=
10,
risk
ratio
(RR)
1.79,
95%
confidence
intervals
(CI):
1.55,
2.06;
p
<
0.01,
I2
40%),
live
birth
4,
RR
2.92,
CI:
2.22,
3.85;
83%),
3,
1.74,
1.34,
2.26;
0%),
positive
serum
β-HCG
14
days
after
ET
8,
1.77,
1.54,
2.03;
36%).
However,
we
did
not
find
that
miscarriage
indicated
significant
difference
between
two
groups
6,
1.04,
0.72,
1.51;
0.83,
0%).
(4)
Conclusions:
findings
this
systemic
meta-analysis
suggest
appears
improve
IVF/ICSI
treatments
RIF.
