The Integration of Cell Therapy and Biomaterials as Treatment Strategies for Remyelination

Life, Год журнала: 2022, Номер 12(4), С. 474 - 474

Опубликована: Март 24, 2022

Multiple sclerosis (MS) is a chronic degenerative autoimmune disease of the central nervous system that causes inflammation, demyelinating lesions, and axonal damage associated with high rate early-onset disability. Disease-modifying therapies are used to mitigate inflammatory process in MS but do not promote regeneration or remyelination; cell therapy may play an important role these processes, modulating inflammation promoting repopulation oligodendrocytes, which responsible for myelin repair. The development genetic engineering has led emergence stable, biocompatible biomaterials favorable environment exogenous cells. This review summarizes available evidence about effects transplantation different types stem cells reported studies several animal models clinical trials human patients. We also address advantages combining biomaterials.

Язык: Английский

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Quantitative comparison of the efficacy of clinical drug treatments for primary progressive multiple sclerosis

Journal of Clinical Neuroscience, Год журнала: 2023, Номер 113, С. 45 - 53

Опубликована: Май 11, 2023

Язык: Английский

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The Efficacy and Safety of Anti-CD20 Antibody Treatments in Relapsing Multiple Sclerosis: A Systematic Review and Network Meta-analysis

CNS Drugs, Год журнала: 2022, Номер 36(11), С. 1155 - 1170

Опубликована: Окт. 16, 2022

Язык: Английский

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Metabolomic profiling of a neurodegenerative retina following optic nerve transection

Molecular Medicine Reports, Год журнала: 2023, Номер 28(3)

Опубликована: Авг. 3, 2023

The degeneration of retinal ganglion cells (RGCs) often causes irreversible vision impairment. Prevention RGC can prevent or delay the deterioration visual function. present study aimed to investigate metabolic profiles following optic nerve transection (ONT) injury and identify potential targets for prevention degeneration. Retinal samples were dissected from ONT group non‑ONT group. untargeted metabolomics carried out using liquid chromatography‑tandem mass spectrometry. involved pathways biomarkers analyzed Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis MetaboAnalyst 5.0. In group, 689 disparate metabolites detected, including lipids lipid‑like molecules. A total 122 successfully annotated enriched in 50 KEGG pathways. Among them, ‘sphingolipid metabolism’ ‘primary bile acid biosynthesis’ identified five selected as candidate detecting with an AUC value 1. revealed that lipid‑related metabolism was pathogenesis neurodegeneration. Taurine, taurochenodesoxycholic acid, taurocholic (TCA), sphingosine, galabiosylceramide are shown promising diagnosis

Язык: Английский

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Neuroanatomy and Neurophysiology

Springer eBooks, Год журнала: 2023, Номер unknown, С. 49 - 70

Опубликована: Янв. 1, 2023

Язык: Английский

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