Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Март 10, 2022
Mitochondria-related
metabolic
reprogramming
plays
a
major
role
in
the
occurrence,
development,
drug
resistance,
and
recurrence
of
acute
myeloid
leukemia
(AML).
However,
roles
mitochondria-related
genes
(MRGs)
prognosis
immune
microenvironment
for
AML
patients
remain
largely
unknown.
In
this
study,
by
least
absolute
shrinkage
selection
operator
(LASSO)
Cox
regression
analysis,
4
MRGs'
(HPDL,
CPT1A,
IDH3A,
ETFB)
signature
was
established
that
demonstrated
good
robustness
TARGET
datasets.
The
univariate
multivariate
analyses
both
MRG
robust
independent
prognostic
factor
overall
survival
prediction
with
high
accuracy
patients.
Based
on
risk
score
calculated
signature,
samples
were
divided
into
high-
low-risk
groups.
Gene
set
enrichment
analysis
(GSEA)
suggested
is
involved
immune-related
pathways.
Via
infiltration
immunosuppressive
we
found
strikingly
positively
correlated
an
cell
expression
critical
checkpoints,
indicating
poor
might
be
caused
tumor
(TME).
summary,
based
MRGs
could
act
as
predicting
clinical
also
reflect
association
microenvironment,
providing
novel
method
therapy
regulation
mitochondrial
function.
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Июль 12, 2022
Inflammation
is
a
defining
factor
in
disease
progression;
epigenetic
modifications
of
this
first
line
defence
pathway
can
affect
many
physiological
and
pathological
conditions,
like
aging
tumorigenesis.
Inflammageing,
one
the
hallmarks
aging,
represents
chronic,
low
key
but
persistent
inflammatory
state.
Oxidative
stress,
alterations
mitochondrial
DNA
(mtDNA)
copy
number
mis-localized
extra-mitochondrial
mtDNA
are
suggested
to
directly
induce
various
immune
response
pathways.
This
could
ultimately
perturb
cellular
homeostasis
lead
consequences.
Epigenetic
remodelling
by
methylation,
post-translational
binding
proteins
regulation
gene
expression
nuclear
or
encoded
non-coding
RNAs,
correlate
with
onset
progression
types
cancer.
Mitochondria
also
capable
regulating
infections
tissue
damage
producing
pro-
anti-inflammatory
signals.
occurs
altering
levels
metabolites
reactive
oxygen
species
(ROS)
levels.
Since
mitochondria
known
as
guardians
response,
it
plausible
that
epigenetics
might
play
pivotal
role
inflammation.
Hence,
review
focuses
on
intricate
dynamics
inflammation,
emphasis
cancer
aging.
Pharmaceuticals,
Год журнала:
2021,
Номер
14(12), С. 1221 - 1221
Опубликована: Ноя. 25, 2021
Alzheimer's
disease
and
Parkinson's
are
the
most
common
forms
of
neurodegenerative
illnesses.
It
has
been
widely
accepted
that
neuroinflammation
is
key
pathogenic
mechanism
in
neurodegeneration.
Both
mitochondrial
dysfunction
enhanced
NLRP3
(nucleotide-binding
oligomerization
domain
(NOD)-like
receptor
protein
3)
inflammasome
complex
activity
have
a
crucial
role
inducing
sustaining
neuroinflammation.
In
addition,
mitochondrial-related
inflammatory
factors
could
drive
formation
complexes,
which
responsible
for
activation,
maturation,
release
pro-inflammatory
cytokines,
including
interleukin-1β
(IL-1β)
interleukin-18
(IL-18).
The
present
review
includes
broadened
approach
to
resulting
abnormal
activation
selected
diseases.
Moreover,
we
also
discuss
potential
mitochondria-focused
treatments
influence
complex.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Март 10, 2022
Mitochondria-related
metabolic
reprogramming
plays
a
major
role
in
the
occurrence,
development,
drug
resistance,
and
recurrence
of
acute
myeloid
leukemia
(AML).
However,
roles
mitochondria-related
genes
(MRGs)
prognosis
immune
microenvironment
for
AML
patients
remain
largely
unknown.
In
this
study,
by
least
absolute
shrinkage
selection
operator
(LASSO)
Cox
regression
analysis,
4
MRGs'
(HPDL,
CPT1A,
IDH3A,
ETFB)
signature
was
established
that
demonstrated
good
robustness
TARGET
datasets.
The
univariate
multivariate
analyses
both
MRG
robust
independent
prognostic
factor
overall
survival
prediction
with
high
accuracy
patients.
Based
on
risk
score
calculated
signature,
samples
were
divided
into
high-
low-risk
groups.
Gene
set
enrichment
analysis
(GSEA)
suggested
is
involved
immune-related
pathways.
Via
infiltration
immunosuppressive
we
found
strikingly
positively
correlated
an
cell
expression
critical
checkpoints,
indicating
poor
might
be
caused
tumor
(TME).
summary,
based
MRGs
could
act
as
predicting
clinical
also
reflect
association
microenvironment,
providing
novel
method
therapy
regulation
mitochondrial
function.
