Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 352 - 352
Опубликована: Март 15, 2024
Ferroptosis
is
an
emerging
type
of
regulated
cell
death
usually
accompanied
by
the
accumulation
ferrous
ions
(Fe2+)
and
lipid
peroxides.
As
metabolic
hub
body,
liver
crucial
for
iron
storage
metabolism.
The
seems
to
be
closely
related
ferroptosis
through
Liver
disease
greatly
threatens
host
health,
exploring
effective
interventions
essential.
Mounting
studies
have
demonstrated
that
one
possible
pathogenic
mechanisms
involved
in
disease.
Targeting
may
provide
a
promising
opportunity
treating
However,
drugs
targeting
are
extremely
limited.
Therefore,
it
urgent
need
develop
new
safe
regulators.
Natural
active
compounds
(NAC),
especially
those
derived
from
traditional
Chinese
medicine,
recently
shown
great
therapeutic
potential
via
modulating
ferroptosis-related
genes
or
pathways.
Here,
we
outline
molecular
mechanism
systematically
summarize
regulatory
function
NAC
on
Finally,
discuss
application
prospects
problems
concerning
as
regulators
managing
Cell Death Discovery,
Год журнала:
2022,
Номер
8(1)
Опубликована: Окт. 8, 2022
In
ferroptosis,
the
roles
of
mitochondria
have
been
controversial.
To
explore
role
mitochondrial
events
in
we
employed
DNA-depleted
ρ0
cells
that
are
resistant
to
cell
death
due
enhanced
expression
antioxidant
enzymes.
Expression
mitochondrial-type
GPx4
(mGPx4)
but
no
other
forms
was
increased
SK-Hep1
cells.
Likely
high
mGPx4
expression,
were
ferroptosis
by
erastin
inhibiting
xCT
channel.
contrast,
susceptible
a
concentration
RSL3
imposing
inhibition.
Accumulation
cellular
ROS
and
oxidized
lipids
observed
erastin-
or
RSL3-treated
ρ+
not
erastin-treated
Mitochondrial
peroxidized
accumulated
only
also
acting
on
plasma
membrane.
quenching
inhibited
dose
RSL3,
suggesting
critical
ferroptosis.
Ferroptosis
more
than
20-fold
lower
MitoQ,
quencher,
compared
DecylQ,
non-targeting
counterpart.
markedly
VDAC
inhibitor,
accompanied
significantly
reduced
accumulation
ROS,
total
lipids,
strongly
supporting
ferroptotic
steps
induced
RSL3.
sorafenib
suppressed
quenchers,
abrogation
sorafenib-induced
lipid
accumulation.
These
results
suggest
upregulation
could
be
ultimate
step
determining
final
fate.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 12, 2024
Abstract
Recent
evidence
indicates
ferroptosis
is
implicated
in
the
pathophysiology
of
various
liver
diseases;
however,
organ-specific
regulation
mechanism
poorly
understood.
Here,
we
demonstrate
7-dehydrocholesterol
reductase
(DHCR7),
terminal
enzyme
cholesterol
biosynthesis,
as
a
regulator
hepatocytes.
Genetic
and
pharmacological
inhibition
(with
AY9944)
DHCR7
suppress
human
hepatocellular
carcinoma
Huh-7
cells.
increases
its
substrate,
(7-DHC).
Furthermore,
exogenous
7-DHC
supplementation
using
hydroxypropyl
β-cyclodextrin
suppresses
ferroptosis.
A
7-DHC-derived
oxysterol
metabolite,
3β,5α-dihydroxycholest-7-en-6-one
(DHCEO),
increased
by
ferroptosis-inducer
RSL-3
-deficient
cells,
suggesting
that
ferroptosis-suppressive
effect
associated
with
oxidation
7-DHC.
Electron
spin
resonance
analysis
reveals
functions
radical
trapping
agent,
thus
protecting
cells
from
We
further
show
AY9944
inhibits
hepatic
ischemia-reperfusion
injury,
genetic
ablation
Dhcr7
prevents
acetaminophen-induced
acute
failure
mice.
These
findings
provide
new
insights
into
regulatory
suggest
potential
therapeutic
option
for
ferroptosis-related
diseases.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Март 13, 2024
Abstract
Ferroptosis
is
an
iron
ion-dependent,
regulatory
cell
death
modality
driven
by
intracellular
lipid
peroxidation
that
plays
a
key
role
in
the
development
of
HCC.
Studies
have
shown
various
clinical
agents
(e.g.,
sorafenib)
ferroptosis
inducer-like
effects
and
can
exert
therapeutic
modulating
different
factors
pathway.
This
implies
targeting
tumor
may
be
very
promising
strategy
for
therapy.
In
this
paper,
we
summarize
prerequisites
defense
systems
occurrence
targets
drug-mediated
action
HCC,
differences
connections
between
other
programmed
deaths.
We
aim
to
theoretical
basis,
classical
inducers
research
progress
HCC
cells,
clued
treatment
regulating
network.
Further
investigation
specific
mechanisms
hepatocellular
carcinoma
interventions
at
stages
will
help
us
deepen
our
understanding
carcinoma,
with
view
providing
new
more
precise
preventive
as
well
measures
patients.
Cells,
Год журнала:
2022,
Номер
11(13), С. 2040 - 2040
Опубликована: Июнь 27, 2022
Ferroptosis,
which
has
been
widely
associated
with
many
diseases,
is
an
iron-dependent
regulated
cell
death
characterized
by
intracellular
lipid
peroxide
accumulation.
It
exhibits
morphological,
biochemical,
and
genetic
characteristics
that
are
unique
in
comparison
to
other
types
of
death.
The
course
ferroptosis
can
be
accurately
the
metabolism
iron,
lipids,
amino
acids,
various
signal
pathways.
In
this
review,
we
summarize
basic
ferroptosis,
its
regulation,
as
well
relationship
between
chronic
diseases
such
cancer,
nervous
system
metabolic
inflammatory
bowel
diseases.
Finally,
describe
regulatory
effects
food-borne
active
ingredients
on
ferroptosis.
Cancers,
Год журнала:
2022,
Номер
14(7), С. 1826 - 1826
Опубликована: Апрель 4, 2022
Ferroptosis,
an
iron
and
reactive
oxygen
species
(ROS)-dependent
non-apoptotic
type
of
regulated
cell
death,
is
characterized
by
a
massive
overload
peroxidation
polyunsaturated
fatty
acids
(PUFAs),
which
finally
results
in
death.
Recent
studies
suggest
that
ferroptosis
can
influence
carcinogenesis
negatively
therefore
may
be
used
as
novel
anti-cancer
strategy.
Hepatocellular
carcinoma
(HCC)
deadly
malignancy
with
poor
chances
survival
the
second
leading
cause
cancer
deaths
worldwide.
Diagnosis
at
already
late
stage
general
resistance
to
current
therapies
responsible
for
dismal
outcome.
As
liver
acts
key
factor
metabolism,
shown
play
important
role
HCC
and,
more
importantly,
hold
potential
eradicate
HCC.
In
this
review,
we
summarize
knowledge
have
application
therapy
option
provide
overview
translation
clinical
practice
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 116074 - 116074
Опубликована: Дек. 25, 2023
Hepatocellular
carcinoma
(HCC)
remains
a
major
global
health
burden,
and
sorafenib,
multi-kinase
inhibitor,
has
shown
effectiveness
in
the
treatment
of
HCC
is
considered
as
first-line
therapy
for
advanced
HCC.
However,
response
to
sorafenib
varies
among
patients,
development
drug
resistance
poses
prevalent
obstacle.
Ferroptosis,
newly
characterized
form
cell
death
featured
by
iron-dependent
lipid
peroxidation,
emerged
critical
player
reaction
The
induction
ferroptosis
been
augment
anticancer
benefits
sorafenib.
it
also
observed
contribute
resistance.
This
review
presents
comprehensive
thorough
analysis
that
elucidates
intricate
relationship
between
over
recent
years,
aiming
formulate
effective
therapeutic
approaches
liver
cancer.
Based
on
this
exploration,
we
propose
innovative
strategies
intended
overcome
via
targeted
modulation
ferroptosis.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Янв. 10, 2024
Abstract
According
to
statistics,
the
incidence
of
liver
cancer
is
increasing
yearly,
and
effective
treatment
imminent.
For
early
cancer,
resection
surgery
currently
most
treatment.
However,
does
not
treat
disease
in
advanced
patients,
so
finding
a
method
with
better
prognosis
necessary.
In
recent
years,
ferroptosis
cuproptosis
have
been
gradually
defined,
related
studies
proved
that
they
show
excellent
results
therapy
cancer.
Cuproptosis
new
form
cell
death,
use
combined
inhibit
production
hepatocellular
carcinoma
cells
has
good
development
prospects
worthy
in-depth
discussion
by
researchers.
this
review,
we
summarize
research
progress
on
treating
analyze
value
immune
propose
potential
pathways
oncotherapy
combination
ferroptosis,
which
can
provide
background
knowledge
for
subsequent
research.
