Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 4799 - 4824
Опубликована: Окт. 1, 2024
Pressure ulcer is common in the bedridden elderly with high mortality and lack of effective treatment. In this study, human-adipose-derived-stem-cells-hyaluronic acid gel (hADSCs-HA gel) was developed applied topically to treat pressure ulcers, which efficacy paracrine mechanisms were investigated through vivo vitro experiments.
Язык: Английский
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
Patients and healthcare systems face significant social financial challenges due to the increasing number of individuals with chronic external internal wounds that fail heal. The complexity healing process remains a serious health concern, despite effectiveness conventional wound dressings in promoting healing. Recent advancements materials science fabrication techniques have led development innovative enhance To further expedite process, novel approaches such as nanoparticles, 3D-printed dressings, biomolecule-infused emerged, along cell-based methods. Additionally, gene therapy technologies are being harnessed generate stem cell derivatives more functional, selective, responsive than their natural counterparts. This review highlights potential biomaterials, 3D bioprinting, gene- therapies However, it also underscores necessity for research address existing integrate these strategies into standard clinical practice.
Язык: Английский
Процитировано
3
Bioactive Materials, Год журнала: 2023, Номер 26, С. 159 - 168
Опубликована: Март 3, 2023
Stem cell therapies have made great progress in the treatment of diabetic wounds during recent decades, while their short vivo residence, alloimmune reactions, undesired behaviors, and dramatic losses functions still hinder translation them into clinic. Here, inspired by natural components stem niches, we presented novel microfluidic hydrogel microcarriers with extracellular matrix (ECM)-like composition adipose-derived cells (ADSCs) encapsulation for wound healing. As was synthesized conjugating hyaluronic acid methacryloyl (HAMA) onto Fibronectin (FN) molecule chain (FN-HAMA), laden ADSCs showed improved bioactivities pro-regenerative capabilities. Based on these features, demonstrated that exhibited significant promotion neovascularization, follicular rejuvenation, collagen deposition a mouse model. These results indicated niche-inspired FN-HAMA clinical potential treatment.
Язык: Английский
Процитировано
32
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(13), С. 2989 - 3000
Опубликована: Янв. 1, 2023
3D bioprinting of a gradient-stiffened gelatin–alginate hydrogel accelerated wound healing by promoting the proliferation, migration, and paracrine secretion encapsulated ADSCs.
Язык: Английский
Процитировано
28
Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 707 - 707
Опубликована: Май 30, 2024
Mesenchymal stem cells (MSCs) have emerged as a promising approach for drug delivery strategies because of their unique properties. These include cell membrane-coated nanoparticles, cell-derived extracellular vesicles, immunomodulatory effects, cell-laden scaffolds, and scaffold-free sheets. MSCs offer advantages such low immunogenicity, homing ability, tumor tropism, making them ideal targeted systems. Stem vesicles gained attention immune properties tumor-homing abilities, presenting potential solution challenges. The relationship between MSC-based the self-renewal differentiation capabilities lies in engineered to serve effective carriers therapeutic agents while maintaining intrinsic exhibit potent immunosuppressive functions strategies. EVs immunogenicity strong tissue repair regeneration. Scaffold-free sheets represent cutting-edge regenerative medicine, offering versatile platform engineering regeneration across different medical specialties. shown great clinical applications medicine ability differentiate into various types, secrete bioactive factors, modulate responses. Researchers are exploring these innovative approaches enhance efficiency effectiveness treating diseases.
Язык: Английский
Процитировано
15
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3901 - 3901
Опубликована: Март 31, 2024
Cardiovascular diseases (CVDs) are the leading cause of death and include several vascular cardiac disorders, such as atherosclerosis, coronary artery disease, cardiomyopathies, heart failure. Multiple treatment strategies exist for CVDs, but there is a need regenerative damaged heart. Stem cells broad variety with great differentiation potential that have immunomodulatory properties. studies evaluated efficacy stem in mesenchymal induced pluripotent cell-derived cardiomyocytes. These demonstrated can improve left ventricle ejection fraction, reduce fibrosis, decrease infarct size. Other investigated methods to survival, engraftment, functionality CVDs. The aim present review summarize current evidence on role how their efficacy.
Язык: Английский
Процитировано
11
Biomedicines, Год журнала: 2022, Номер 10(11), С. 2902 - 2902
Опубликована: Ноя. 11, 2022
Hyaluronic acid (HA) has been suggested to be a preferential material for the delivery of adipose-derived stem cells (ASCs) in wound healing. By incorporating HA electrospun poly (lactide-co-glycolide) (PLGA)/gelatin (PG) fibrous membrane scaffolds (FMS), we aim fabricate PLGA/gelatin/HA (PGH) FMS provide milieu 3D culture and ASCs. The prepared shows adequate cytocompatibility is suitable attachment growth Compared with PG, PGH offers an enhanced proliferation rate ASCs, higher cell viability, better maintains ASC-like phenotype during vitro culture. ASCs also show upregulated expression genes associated angiogenesis From rat full-thickness healing model, treated PGH/ASCs can accelerate closure compared wounds PGH, alginate dressing, gauze. H&E Masson’s trichrome staining, PGH/ASC treatment promote by increasing epithelialization forming well-organized dermis. This supported immunohistochemical staining macrophages α-smooth muscle actin, where early recruitment macrophages, macrophage polarization, was found due delivered content type III collagen than I within newly formed skin tissue, implying scarless Taken together, using as topical dressing therapeutic shown significantly rats, through modulating immunoreaction, promoting angiogenesis, reducing scar formation at sites.
Язык: Английский
Процитировано
22
Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10
Опубликована: Авг. 22, 2022
Current wound dressing based on hydrogel offers a promising way to accelerate the healing process, yet great challenges remain in development of highly integrated and efficient platform with combination therapeutic biomolecules stem cells. Herein, natural from egg white can be conveniently obtained by feasible physical crosslinking, prepared features interconnected microporous channels, direct 3D printing, cytocompatibility, intrinsic advance cell behavior. The printed hydrogels promote adhesion proliferation adipose-derived cells (ASCs) without obvious cytotoxicity. In addition, this accompanied accelerates through enhancement fibroblast proliferation, angiogenesis, collagen rearrangement bed. provides an effective caring product possessing low cost, easy availability along ready manufacturing, advanced effect, which may extended for management chronic or other complicated wounds.
Язык: Английский
Процитировано
17
Stem Cell Research & Therapy, Год журнала: 2022, Номер 13(1)
Опубликована: Сен. 6, 2022
Urethral stricture and reconstruction are one of the thorny difficult problems in field urology. The continuous development tissue engineering biomaterials has given new therapeutic thinking to this problem. Bacterial cellulose (BC) is an excellent biomaterial due its accessibility strong plasticity. Moreover, adipose-derived stem cells (ADSCs) could enhance their wound healing ability through directional modification.
Язык: Английский
Процитировано
16
Опубликована: Янв. 15, 2025
Kronik Yara Kavramı ve Çeşitleri Kıvanç ÖNCÜ İyileşmesinin Fizyolojisi Dilek SAĞIR İyileşmesinde Büyüme Faktörleri Sitokinlerin Etkileri Burcu DEMİREL YILMAZ Tedavisi Bakımı Anıl ÇELEBİ Hilal Büşra KAYA Biyofiziksel Biyolojik Teknolojiler İle Yönetimi: Negatif Basınçlı Özhan ÖZCAN Elektriksel Stimülasyon, Işın Tedavisi, Topikal Oksijen Ozon Larva Jet Lavage İrrigasyon Sistemi, Düşük Yoğunluklu Lazer Ultrasound Hiperbarik ile İyileşmesi Hatice CEYLAN Kök Hücre Canan VEJSELOVA SEZER Bakımında Kullanılan Pansuman Materyalleri Sezgin UZUN Gelişiminin Önlenmesi Yönetimi Bilge BAL ÖZKAPTAN
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161827 - 161827
Опубликована: Март 1, 2025
Процитировано
0