Synergistic Mechanisms of Selected Polyphenols in Overcoming Chemoresistance and Enhancing Chemosensitivity in Colorectal Cancer DOI Creative Commons
Kha Wai Hon, Rakesh Naidu

Antioxidants, Год журнала: 2024, Номер 13(7), С. 815 - 815

Опубликована: Июль 7, 2024

Colorectal cancer (CRC) is a leading cause of deaths worldwide. Despite significant advances in medical treatment, chemotherapy as monotherapy can lead to substantial side effects and chemoresistance. This underscores the need for therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize cells overcome resistance standard drugs. In recent years, scientists have been searching natural compounds be used chemosensitizers addition conventional medications synergistic treatment CRC. Polyphenols represent diverse group target induce anti-cancer effects. Additionally, polyphenols shown work synergistically with chemotherapeutics other cells. review aims provide comprehensive insight into mechanisms selected CRC Further research clinical trials warranted fully harness combined or improving outcomes.

Язык: Английский

Rowanberry—A Source of Bioactive Compounds and Their Biopharmaceutical Properties DOI Creative Commons

Ofelia Arvinte,

Lacrimioara Șenilă, Anca Becze

и другие.

Plants, Год журнала: 2023, Номер 12(18), С. 3225 - 3225

Опубликована: Сен. 11, 2023

After a period of intense development in the synthesis pharmaceutical industry, plants are making comeback public focus as remedies or therapeutic adjuvants and disease prevention ensuring wellbeing equilibrium human body. Plants being recommended more alimentation, their natural form, extracts, supplements functional aliments. People, general, search new sources nutrients phytochemicals. As result, scientific research turns to lesser known used plants, among them rowanberries, species fruit very rich underused due bitter astringent taste lack knowledge regarding beneficial effects these fruit. Rowan fruits (rowanberries) source vitamins, polysaccharides, organic acids minerals. They also polyphenols, which often correlated with treatment modern world diseases. This article presents existing data chemical composition, active principles biopharmaceutical properties rowan different opportunities for usage.

Язык: Английский

Процитировано

13

Effect of punicalagin on the autophagic cell death in triple-negative breast cancer cells DOI
Zeeshan Ahmad Bhutta, Ryeo‐Eun Go, Kyung‐Chul Choi

и другие.

Toxicological Research, Год журнала: 2024, Номер 40(4), С. 585 - 598

Опубликована: Июнь 12, 2024

Язык: Английский

Процитировано

5

Probing Baicalin as potential inhibitor of Aurora kinase B: A step towards lung cancer therapy DOI

Saba Noor,

Arunabh Choudhury,

Ali Raza

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 258, С. 128813 - 128813

Опубликована: Дек. 18, 2023

Язык: Английский

Процитировано

10

Phytometabolites as modulators of breast cancer: a comprehensive review of mechanistic insights DOI
Priyanka Sharma, Khushi Gupta,

Sumit Kumar Khandai

и другие.

Medical Oncology, Год журнала: 2024, Номер 41(2)

Опубликована: Янв. 3, 2024

Язык: Английский

Процитировано

4

Synergistic Mechanisms of Selected Polyphenols in Overcoming Chemoresistance and Enhancing Chemosensitivity in Colorectal Cancer DOI Creative Commons
Kha Wai Hon, Rakesh Naidu

Antioxidants, Год журнала: 2024, Номер 13(7), С. 815 - 815

Опубликована: Июль 7, 2024

Colorectal cancer (CRC) is a leading cause of deaths worldwide. Despite significant advances in medical treatment, chemotherapy as monotherapy can lead to substantial side effects and chemoresistance. This underscores the need for therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize cells overcome resistance standard drugs. In recent years, scientists have been searching natural compounds be used chemosensitizers addition conventional medications synergistic treatment CRC. Polyphenols represent diverse group target induce anti-cancer effects. Additionally, polyphenols shown work synergistically with chemotherapeutics other cells. review aims provide comprehensive insight into mechanisms selected CRC Further research clinical trials warranted fully harness combined or improving outcomes.

Язык: Английский

Процитировано

4