Short-term subacute di(2-ethylhexyl) phthalate exposure disrupts gut microbiota, metabolome, liver transcriptome, immunity, and induces liver injury in rats

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117948 - 117948

Опубликована: Фев. 26, 2025

Язык: Английский

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Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway

Journal of Environmental Management, Год журнала: 2024, Номер 371, С. 123235 - 123235

Опубликована: Ноя. 6, 2024

Язык: Английский

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Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119557 - 119557

Опубликована: Фев. 1, 2025

Язык: Английский

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Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 273, С. 116161 - 116161

Опубликована: Март 1, 2024

Di(2-ethylhexyl) phthalate (DEHP) is a worldwide common plasticizer. Nevertheless, DEHP easily leached out to the environment due lack of covalent bonds with plastic. High dose exposure often observed in hemodialysis patients because continual usage plastic medical devices. Although liver major organ that catabolizes DEHP, impact long-term on sensitivity cancer chemotherapy remains unclear. In this study, we established DEHP-exposed hepatocellular carcinoma (HCC) cells and two NOD/SCID mice models investigate effects underlying mechanisms chemosensitivity HCC. The results showed potentially increased epithelial-mesenchymal transition (EMT) HCC cells. Next generation sequencing cell adhesion/migratory related genes expression blunted sorafenib treatment induced alterations. Long-term reduced sorafenib-induced anti-migratory effect by enhancing EMT transcription factors (slug, twist, ZEB1) mesenchymal protein (vimentin) expression. model, exhibited higher growth rate. Regarding anti-HCC sorafenib, subcutaneous HuH7 tumor grew slowly sorafenib-treated mice. Nonetheless, anti-tumor was not Higher markers proliferating nuclear antigen (PCNA) were found conclusion, promoted migratory activity decreased tumor-bearing

Язык: Английский

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Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Seabirds in crisis: Plastic ingestion induces proteomic signatures of multiorgan failure and neurodegeneration

Science Advances, Год журнала: 2025, Номер 11(11)

Опубликована: Март 12, 2025

Understanding plastics’ harmful impacts on wildlife would benefit from the application of hypothesis agnostic testing commonly used in medical research to detect declines population health. Adopting a data-driven, proteomic approach, we assessed changes 745 proteins free-living nonmodel organism with differing levels plastic exposure. Seabird chicks heavily affected by ingestion demonstrated range negative health consequences: Intracellular components that should not be found blood were frequently detected, indicative cell lysis. Secreted less abundant, indicating stomach, liver, and kidneys are functioning as normal. Alarmingly, these signatures included evidence neurodegeneration <90-day-old seabird high ingested plastic. The reflect effects distal site exposure (i.e., stomach). Notably, metrics assess condition (such body mass) do provide an accurate description or ingestion.

Язык: Английский

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Gestational and lactational exposure to DEHP triggers ACSL4/TFR-mediated hippocampal neuronal ferroptosis via YAP activation: implication for the neurocognitive disorders in male offspring

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138081 - 138081

Опубликована: Март 1, 2025

Язык: Английский

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Oxidative stress and iron homeostasis imbalance mediate AlCl3-induced liver damage in mice

Journal of Environmental Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?

Reports — Medical Cases Images and Videos, Год журнала: 2023, Номер 6(3), С. 36 - 36

Опубликована: Авг. 1, 2023

In 1957, Arvid Carlsson discovered that dopamine, at the time believed to be nothing more than a norepinephrine precursor, was brain neurotransmitter in and of itself. By 1963, postsynaptic dopamine blockade had become cornerstone psychiatric treatment as it appeared have deciphered “chlorpromazine enigma”, 1950s term, denoting action mechanism antipsychotic drugs. The same year, Lindqvist launched hypothesis schizophrenia, ushering era psychopharmacology. At present, six decades later, although watered down by three consecutive revisions, model remains vogue. latest emendation this paradigm proposes “environmental genetic factors” converge on dopaminergic pathways, upregulating transmission. Aryl hydrocarbon receptors, expressed gut blood–brain barrier, respond variety endogenous exogenous ligands, including probably participating interoceptive awareness, feed-back loop, conveying intestinal barrier status insular cortex. conceptualization aryl receptor bridge, connecting vagal terminals with microbiome, may elucidate aspects schizophrenia seemingly incongruous hypothesis, such increased prevalence urban areas, distance from equator, autoantibodies, or comorbidity inflammatory bowel disease human immunodeficiency 1 virus. review article, after short discussion outcome studies insight, we take closer look drugs, attempting answer question: do these agents exert their beneficial effects via both nondopaminergic mechanisms? Finally, discuss potential new therapies, transcutaneous stimulation, restoring homeostasis barrier.

Язык: Английский

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Metabolism-Disrupting Chemical Mixtures during Pregnancy, Folic Acid Supplementation, and Liver Injury in Mother-Child Pairs

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Scarce knowledge about the impact of metabolism-disrupting chemicals (MDCs) on liver injury limits opportunities for intervention. We evaluated pregnancy MDC-mixture associations with and effect modification by folic acid (FA) supplementation in mother-child pairs. studied ∼200 pairs from Mexican PROGRESS cohort, measured 43 MDCs during (estimated air pollutants, blood/urine metals or metalloids, urine high- low-molecular-weight phthalate [HMWPs, LMWPs] organophosphate-pesticide [OP] metabolites), serum enzymes (ALT, AST) at ∼9 years post-parturition. defined as elevated children, using established clinical scores steatosis fibrosis mothers (i.e., AST:ALT, FLI, HSI, FIB-4). Bayesian Weighted Quantile Sum regression assessed outcomes. further examined chemical-chemical interactions self-reported FA supplementation. In many MDC-mixtures were associated Per quartile HMWP-mixture increase, ALT increased 10.1% (95%CI: 1.67%, 19.4%) AST 5.27% (95% CI: 0.80%, 10.1%). LMWP-mixtures pollutant-mixtures higher ALT, respectively. Air pollutant non-essential metal/element attenuated maternal cobalt blood concentrations ( p -interactions<0.05). mothers, only LMWP-mixture was [OR=1.53 1.01, 2.28) HSI>36, OR=1.62 1.05, 2.49) AST:ALT<1]. most (null) supplementation≥600mcg/day Pregnancy MDC exposures may increase risk, particularly children. These be levels.

Язык: Английский

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