International Journal of Medical Toxicology and Forensic Medicine,
Год журнала:
2024,
Номер
13(04), С. 43485 - 43485
Опубликована: Янв. 28, 2024
Background:
Ferroptosis,
an
oxidative
and
iron-dependent
cell
death,
is
a
new
type
of
regulated
death.
There
are
few
studies
on
the
mechanisms
ferroptosis
in
skin
related
diseases.
Arsenic
shown
to
induce
This
study
aimed
decipher
relationship
between
arsenic
exposure
death
skin.
Methods:
Arsenic-gene
interactions
were
obtained.
Then,
skin-specific
arsenic-gene
screened.
Ferroptosis-related
genes
identified.
Analysis
functional
biological
was
performed
identify
possible
mechanisms.
Results:
The
ferroptosis-related
showed
overlap
59
genes.
Functional
enrichment,
protein-protein
interaction,
transcription
factor
(TF)/miRNA
target
gene
interaction
analyses
used
look
into
mechanism
arsenic-induced
ACTB,
CTNNB1,
HSPA8,
SRC,
RACK1,
CD44,
SQSTM1
identified
as
key
proteins.
Gene
ontology
analysis
these
proteins
indicated
mitochondrial
morphology
functionality
changes
following
HIF1A
SP1
TFs
regulate
large
number
compared
other
TFs.
Ten
miRNAs
with
high
ferroptosis-associated
Conclusion:
work
investigated
regulators,
highlighted
role
mitochondria
this
exposure.
Clinical Cosmetic and Investigational Dermatology,
Год журнала:
2025,
Номер
Volume 18, С. 567 - 577
Опубликована: Март 1, 2025
Previous
research
has
shown
that
metabolites
(especially
lipid-related
metabolites)
have
a
significant
influence
in
the
development
of
atopic
dermatitis
(AD).
However,
there
is
no
evidence
causal
connection
between
and
AD
risk.
The
specific
mechanisms
require
further
elucidation.
Our
study
employed
two-sample
Mendelian
randomization
(TSMR)
strategy
to
investigate
how
metabolite
traits
affect
AD.
Utilizing
publicly
accessible
GWAS
data,
we
conducted
TSMR
studies
relationship
233
(213
20
traits)
primarily
Inverse-variance
weighted
method
four
ancillary
methods
analyze
causation.
Sensitivity
analysis
was
performed
guarantee
results
were
trustworthy.
Reverse
MR
used
for
investigating
reverse
causality.
After
analyzing
datasets
AD,
13
identified
as
positive.
result
indicates
total
cholesterol
very
small
VLDL,
esters
free
IDL,
concentration
medium
LDL
particles,
large
particle,
chylomicrons
extremely
VLDL
triglyceride
levels
lipid
VLD,
phospholipid
phospholipids
LDL,
ratio
18:2
linoleic
acid
fatty
acids
exhibited
negative
effects
on
found
serum
decreased
patients
with
analyses
ensure
stability
our
results.
These
findings
highlight
definite
correlation
demonstrating
role
traits.
significantly
reduced
unavoidable
confounders
may
set
framework
prospective
therapeutic
approaches
call
investigation
validate
them.
Antioxidants,
Год журнала:
2025,
Номер
14(5), С. 555 - 555
Опубликована: Май 7, 2025
Lipid
peroxidation
(LPO)
is
a
biochemical
process
through
which
lipids
are
subjected
to
reaction
in
the
presence
of
free
radicals.
The
can
cause
alterations
biological
membranes
and
formation
substances
harmful
body
that
form
aggregates
with
proteins
nucleic
acids.
Malondialdehyde
(MDA)
4-hydroxynonenal
(4-HNE)
main
products
LPO.
These
compounds
have
cytotoxic
genotoxic
properties
contribute
pathogenesis
various
diseases.
This
research
focuses
on
correlation
between
LPO
skin
For
some
diseases,
such
as
psoriasis,
vitiligo,
alopecia,
been
shown
clear
role
disease.
aldehydic
like
MDA
4-HNE
enhance
inflammation
by
stimulating
pro-inflammatory
genes
producing
cytokines.
Furthermore,
these
stimulate
cell
death
increase
oxidative
stress.
other
diseases
(atopic
dermatitis,
urticaria,
pemphigus,
melanoma),
unclear,
even
if
levels
biomarkers
elevated
proportion
severity
also
be
exploited
counteract
proliferation
neoplastic
cells.
Therefore,
enhancing
would
play
an
adjuvant
therapy
melanoma.
In
particular,
therapeutic
implication
resulting
from
cytotoxicity
induced
photodynamic
used
for
treatment
melanoma
could
interest
future.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
AbstractBackground:
Limited
research
has
been
conducted
on
the
interaction
between
ferroptosis
and
epithelial-mesenchymal
transition
(EMT)
their
combined
effect
esophageal
squamous
cell
carcinoma
(ESCC)
patient
prognosis.
The
present
study
aimed
to
develop
a
prognostic
model
based
impact
of
EMT
ESCC
prognosis
for
clinical
application.
Methods:
Gene
expression
levels
data
patients
were
obtained
from
GSE53625
dataset
in
gene
omnibus
(GEO)
database,
cancer
genome
atlas
(TCGA)
as
validation
set.
By
combining
results
cox
regression
analysis
least
absolute
shrinkage
selection
operator
(LASSO)
analysis,
we
selected
nine
genes
associated
with
prognosis,
which
then
used
construct
model.
Immune
infiltration
was
evaluated
using
CIBERSORT
single-sample
Set
Enrichment
Analysis
methods.
Results:
Nine
key
screened
integrated
score
(FEIS).
Compared
low-FEIS
group,
high-FEIS
group
demonstrated
shorter
overall
survival
period.
immune
showed
an
increase
elevated
checkpoint
molecules
group.
A
nomogram
constructed
accurately
predict
Conclusion:
Our
introduced
novel
tool
that
integrates
-and
EMT-related
biomarker,
offered
valuable
insights
developing
personalized
treatment
strategies
patients.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 15, 2024
Abstract
Alopecia
areata
(AA)
is
a
common
non-scarring
hair
loss
condition
driven
by
the
collapse
of
immune
privilege
and
oxidative
stress.
The
role
ferroptosis,
type
cell
death
linked
to
stress,
in
AA
yet
be
explored,
even
though
it's
implicated
various
diseases.
Using
transcriptome
data
from
patients
controls
datasets
GSE68801
GSE80342,
we
aimed
identify
diagnostic
marker
genes
ferroptosis.
We
employed
Single-sample
gene
set
enrichment
analysis
(ssGSEA)
for
infiltration
evaluation.
Correlations
between
ferroptosis-related
differentially
expressed
(FRDEGs)
cells/functions
were
identified
using
Spearman
analysis.
Feature
selection
was
done
through
Support
vector
machine-recursive
feature
elimination
(SVM-RFE)
LASSO
regression
models.
Validation
performed
GSE80342
dataset,
followed
hierarchical
internal
validation.
also
constructed
nomogram
assess
predictive
ability
FRDEGs
AA.
Furthermore,
expression
distribution
these
molecules
confirmed
immunofluorescence.
Four
genes,
namely
SLC40A1,
LCN2,
CREB5,
SLC7A11,
as
markers
A
prediction
model
based
on
showed
high
accuracy
(AUC
=
0.9052).
Immunofluorescence
revealed
reduced
compared
normal
(NC),
with
SLC40A1
CREB5
showing
significant
differences.
Notably,
they
primarily
localized
outer
root
sheath
proximity
sebaceous
glands.
Our
study
several
associated
These
findings,
emerging
integration
machine
learning,
contribute
evolving
understanding
therapeutic
strategies
Importantly,
this
research
lays
solid
foundation
subsequent
studies
exploring
intricate
relationship
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
Год журнала:
2024,
Номер
32(8), С. 1347 - 1357
Опубликована: Янв. 1, 2024
Hepatocellular
carcinoma
(HCC)
poses
a
significant
threat
to
human
health.
Resistance
sorafenib
in
the
chemotherapy
of
HCC
is
common
and
issue
that
profoundly
impacts
clinical
treatment.
While
several
members
transmembrane
(TMEM)
protein
family
have
been
implicated
occurrence
progression
HCC,
association
between
TMEM39b
remains
unexplored.
This
study
revealed
overexpression
which
correlated
with
poor
prognosis.
Subsequent
investigation
RAS-selective
lethal
3
(RSL3)
induced
pronounced
ferroptosis
knocking
down
expression
significantly
decreased
its
severity.
Similarly,
following
induction
by
sorafenib,
also
severity
ferroptosis,
enhancing
tolerance
sorafenib.
In
conclusion,
we
propose
promotes
tumor
resistance
inhibiting
HCC.
