Investigating the Mechanism of Arsenic-induced Ferroptosis in the Skin DOI Creative Commons
Mehdi Koushki, Nasrin Amiri‐Dashatan, Mitra Rezaei

и другие.

International Journal of Medical Toxicology and Forensic Medicine, Год журнала: 2024, Номер 13(04), С. 43485 - 43485

Опубликована: Янв. 28, 2024

Background: Ferroptosis, an oxidative and iron-dependent cell death, is a new type of regulated death. There are few studies on the mechanisms ferroptosis in skin related diseases. Arsenic shown to induce This study aimed decipher relationship between arsenic exposure death skin. Methods: Arsenic-gene interactions were obtained. Then, skin-specific arsenic-gene screened. Ferroptosis-related genes identified. Analysis functional biological was performed identify possible mechanisms. Results: The ferroptosis-related showed overlap 59 genes. Functional enrichment, protein-protein interaction, transcription factor (TF)/miRNA target gene interaction analyses used look into mechanism arsenic-induced ACTB, CTNNB1, HSPA8, SRC, RACK1, CD44, SQSTM1 identified as key proteins. Gene ontology analysis these proteins indicated mitochondrial morphology functionality changes following HIF1A SP1 TFs regulate large number compared other TFs. Ten miRNAs with high ferroptosis-associated Conclusion: work investigated regulators, highlighted role mitochondria this exposure.

Язык: Английский

The Causal Relationship Between Circulating Metabolites and the Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Jian Chen, Dan Jian,

Bingxue Bai

и другие.

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2025, Номер Volume 18, С. 567 - 577

Опубликована: Март 1, 2025

Previous research has shown that metabolites (especially lipid-related metabolites) have a significant influence in the development of atopic dermatitis (AD). However, there is no evidence causal connection between and AD risk. The specific mechanisms require further elucidation. Our study employed two-sample Mendelian randomization (TSMR) strategy to investigate how metabolite traits affect AD. Utilizing publicly accessible GWAS data, we conducted TSMR studies relationship 233 (213 20 traits) primarily Inverse-variance weighted method four ancillary methods analyze causation. Sensitivity analysis was performed guarantee results were trustworthy. Reverse MR used for investigating reverse causality. After analyzing datasets AD, 13 identified as positive. result indicates total cholesterol very small VLDL, esters free IDL, concentration medium LDL particles, large particle, chylomicrons extremely VLDL triglyceride levels lipid VLD, phospholipid phospholipids LDL, ratio 18:2 linoleic acid fatty acids exhibited negative effects on found serum decreased patients with analyses ensure stability our results. These findings highlight definite correlation demonstrating role traits. significantly reduced unavoidable confounders may set framework prospective therapeutic approaches call investigation validate them.

Язык: Английский

Процитировано

0

The molecular mechanism of ferroptosis in the Pacific oyster Crassostrea gigas under Erastin treatment or high temperature stress DOI

Jinyuan Leng,

Jiejie Sun,

Zhicheng Guo

и другие.

Developmental & Comparative Immunology, Год журнала: 2025, Номер unknown, С. 105366 - 105366

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis DOI Creative Commons
Xunhu Dong, Ying He,

Xiaofeng Hu

и другие.

Redox Biology, Год журнала: 2025, Номер unknown, С. 103628 - 103628

Опубликована: Апрель 1, 2025

Nitrogen mustard (NM) causes severe skin injury that is lack of effective and targeted therapies. Vitamin D3 (VD3) emerges as a promising treatment option for NM-caused dermal toxicity; however, the underlying mechanisms are currently unclear. Herein, we identified NM markedly promoted ferroptosis by measurement decreased cell viability, glutathione, glutathione peroxidase 4 solute carrier family 7 member 11 levels, increased ROS, lipid iron/Fe2+ malondialdehyde contents in vitro vivo. Ferrostin-1 (Fer-1, inhibitor) attenuated death keratinocytes. Meanwhile, significantly inhibited phosphorylation AKT1 glycogen synthase kinase 3β (GSK3β) nuclear factor erythroid 2-related 2 (Nrf2) translocation, LINC00707 expression. Furthermore, NM-induced keratinocytes was abolished with agonists Nrf2 (tBHQ) (SC79), inhibitor GSK3β (AR-A014418), overexpression or knockdown. Mechanistically, directly bound protein domain suppressed its activated thereby inactivating Nrf2, subsequently inducing NM-treated Moreover, VD3 notably expression, inactivated GSK3β, translocation cytotoxicity induced The protective effects against toxicity were blocked erastin (a inducer), siRNA, enhanced knockdown Fer-1 In conclusion, ameliorated inhibiting ferroptosis, which partially mediated through LINC00707-AKT1-GSK3β-Nrf2 signaling pathway.

Язык: Английский

Процитировано

0

Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential DOI
Thanyaporn Direksunthorn, Abdulrahman T. Ahmed,

Nakaraj Pluetrattanabha

и другие.

Journal of Physiology and Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

0

Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation DOI Creative Commons
Federica Li Pomi, Luca Gammeri, Francesco Borgia

и другие.

Antioxidants, Год журнала: 2025, Номер 14(5), С. 555 - 555

Опубликована: Май 7, 2025

Lipid peroxidation (LPO) is a biochemical process through which lipids are subjected to reaction in the presence of free radicals. The can cause alterations biological membranes and formation substances harmful body that form aggregates with proteins nucleic acids. Malondialdehyde (MDA) 4-hydroxynonenal (4-HNE) main products LPO. These compounds have cytotoxic genotoxic properties contribute pathogenesis various diseases. This research focuses on correlation between LPO skin For some diseases, such as psoriasis, vitiligo, alopecia, been shown clear role disease. aldehydic like MDA 4-HNE enhance inflammation by stimulating pro-inflammatory genes producing cytokines. Furthermore, these stimulate cell death increase oxidative stress. other diseases (atopic dermatitis, urticaria, pemphigus, melanoma), unclear, even if levels biomarkers elevated proportion severity also be exploited counteract proliferation neoplastic cells. Therefore, enhancing would play an adjuvant therapy melanoma. In particular, therapeutic implication resulting from cytotoxicity induced photodynamic used for treatment melanoma could interest future.

Язык: Английский

Процитировано

0

A dual EMT-ferroptosis gene signature predicts survival and immune infiltration in esophageal squamous cell carcinoma DOI
Zhidong Wang, Gong Cheng, Ce Chao

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract Background: Limited research has been conducted on the interaction between ferroptosis and epithelial-mesenchymal transition (EMT) their combined effect esophageal squamous cell carcinoma (ESCC) patient prognosis. The present study aimed to develop a prognostic model based impact of EMT ESCC prognosis for clinical application. Methods: Gene expression levels data patients were obtained from GSE53625 dataset in gene omnibus (GEO) database, cancer genome atlas (TCGA) as validation set. By combining results cox regression analysis least absolute shrinkage selection operator (LASSO) analysis, we selected nine genes associated with prognosis, which then used construct model. Immune infiltration was evaluated using CIBERSORT single-sample Set Enrichment Analysis methods. Results: Nine key screened integrated score (FEIS). Compared low-FEIS group, high-FEIS group demonstrated shorter overall survival period. immune showed an increase elevated checkpoint molecules group. A nomogram constructed accurately predict Conclusion: Our introduced novel tool that integrates -and EMT-related biomarker, offered valuable insights developing personalized treatment strategies patients.

Язык: Английский

Процитировано

0

Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases DOI
Hong Chen,

Bingchun Liu,

Peixin Xu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 298, С. 118269 - 118269

Опубликована: Май 10, 2025

Язык: Английский

Процитировано

0

Identification of SLC40A1, LCN2, CREB5, and SLC7A11 as ferroptosis-related biomarkers in alopecia areata through machine learning DOI Creative Commons
Wen Xu, Dongfan Wei, Xiuzu Song

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 15, 2024

Abstract Alopecia areata (AA) is a common non-scarring hair loss condition driven by the collapse of immune privilege and oxidative stress. The role ferroptosis, type cell death linked to stress, in AA yet be explored, even though it's implicated various diseases. Using transcriptome data from patients controls datasets GSE68801 GSE80342, we aimed identify diagnostic marker genes ferroptosis. We employed Single-sample gene set enrichment analysis (ssGSEA) for infiltration evaluation. Correlations between ferroptosis-related differentially expressed (FRDEGs) cells/functions were identified using Spearman analysis. Feature selection was done through Support vector machine-recursive feature elimination (SVM-RFE) LASSO regression models. Validation performed GSE80342 dataset, followed hierarchical internal validation. also constructed nomogram assess predictive ability FRDEGs AA. Furthermore, expression distribution these molecules confirmed immunofluorescence. Four genes, namely SLC40A1, LCN2, CREB5, SLC7A11, as markers A prediction model based on showed high accuracy (AUC = 0.9052). Immunofluorescence revealed reduced compared normal (NC), with SLC40A1 CREB5 showing significant differences. Notably, they primarily localized outer root sheath proximity sebaceous glands. Our study several associated These findings, emerging integration machine learning, contribute evolving understanding therapeutic strategies Importantly, this research lays solid foundation subsequent studies exploring intricate relationship

Язык: Английский

Процитировано

2

Tmem39b promotes tumor progression and sorafenib resistance by inhibiting ferroptosis in hepatocellular carcinoma DOI

Ming Zhuang,

Xue Zhang, Lu Li

и другие.

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Год журнала: 2024, Номер 32(8), С. 1347 - 1357

Опубликована: Янв. 1, 2024

Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance sorafenib in the chemotherapy of HCC is common and issue that profoundly impacts clinical treatment. While several members transmembrane (TMEM) protein family have been implicated occurrence progression HCC, association between TMEM39b remains unexplored. This study revealed overexpression which correlated with poor prognosis. Subsequent investigation RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis knocking down expression significantly decreased its severity. Similarly, following induction by sorafenib, also severity ferroptosis, enhancing tolerance sorafenib. In conclusion, we propose promotes tumor resistance inhibiting HCC.

Язык: Английский

Процитировано

2

Papain Suppresses Atopic Skin Inflammation through Anti-Inflammatory Activities Using In Vitro and In Vivo Models DOI Creative Commons
Hye-Min Kim, Yun‐Mi Kang, Minho Lee

и другие.

Antioxidants, Год журнала: 2024, Номер 13(8), С. 928 - 928

Опубликована: Июль 30, 2024

Papain (PN) is a proteolytic enzyme derived from

Язык: Английский

Процитировано

2