Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2023, Номер 1867(10), С. 130440 - 130440
Опубликована: Июль 30, 2023
Язык: Английский
iScience, Год журнала: 2024, Номер 27(4), С. 109614 - 109614
Опубликована: Март 28, 2024
Язык: Английский
Процитировано
3
Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Myocardial infarction (MI) is a leading cause of mortality among cardiovascular diseases. Following MI, the damaged myocardium progressively being replaced by fibrous scar tissue, which exhibits poor electrical conductivity, ultimately resulting in arrhythmias and adverse cardiac remodeling. Due to their extracellular matrix‐like structure excellent biocompatibility, hydrogels are emerging as focal point tissue engineering. However, traditional lack necessary conductivity restore signal transmission infarcted regions. Imparting while also enhancing adhesive properties enables them adhere closely myocardial establish stable connections, facilitate synchronized contraction repair within area. This paper reviews strategies for constructing conductive hydrogels, focusing on application MI repair. Furthermore, challenges future directions developing discussed.
Язык: Английский
Процитировано
0
Journal of Cancer and Tumor International, Год журнала: 2025, Номер 15(1), С. 24 - 37
Опубликована: Янв. 16, 2025
Bioelectrical signals which are directed by ion channels and membrane potential (V_mem), play a crucial role in many cellular processes including proliferation differentiation. It has also been known to influence such as gene expression, epigenetics, tumor progression key aspects of cancer development. This study explores the bioelectric signaling oncogenesis, highlighting possible therapeutic implications. An inferential review existing literature was done understand outcomes integrating Tumor-Treating Fields (TTFields) with traditional therapies like chemotherapy immunotherapy. Relevant sources were analyzed gain mechanistic insights from clinical non-clinical studies deduce Dysregulated channel activity abnormal hallmark findings cells. Deviant seen tumors promote oncogene activation suppressor silencing. These changes affect chromatin remodeling through pathways involving calcium signaling, histone modifications, DNA methylation. Therapeutically, targeting channels, potassium sodium-proton exchangers may offer novel strategy disrupt growth. Bioelectric stimulation, using techniques optogenetics, can help reprogram cells induce differentiation or apoptosis. There diagnostic advancements that leverage markers, depolarized potential, for early detection electrophysiological imaging wearable sensors. modulation enhance drug uptake, improve immune responses normalizing microenvironment, enable targeted delivery electroporation. genome regulation significant potential. Further recommended provide essential into harnessing bioelectricity advanced management improved patient outcomes.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3639 - 3639
Опубликована: Апрель 11, 2025
Calcium movement and concentration in the cell plays significant roles normal physiology diseases such as cancer. The significance of this ion oncogenesis suggests that membrane-relevant proteins are involved its regulation deregulated various cancers. These channels transporters could be targets for therapeutic interventions. An evaluation expression transient receptor potential (TRP) prostate cancer was performed using publicly available genomic proteome data. Two TRP family members with high cancers, TRPML2 TRPM4, were chosen further analysis uncover associations their level clinical pathologic characteristics. Several expressed cancers at protein including TRPML1, TRPML2, TRPC1 TRPP3. At mRNA level, MCOLN2 TRPM4 strongly a sub-set Cases associated frequent ERG fusions trend better survival outcomes. In contrast, cases lower fusion frequency than low expression. prognosis not different from counterparts having sub-sets two well-expressed super family, have divergent most prevalent molecular aberrations, fusions. results imply diverse regulations would to taken into consideration when devising interventions targeting individual channels.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2023, Номер 12(8), С. 1148 - 1148
Опубликована: Апрель 13, 2023
Developmental patterning is essential for regulating cellular events such as axial patterning, segmentation, tissue formation, and organ size determination during embryogenesis. Understanding the mechanisms remains a central challenge fundamental interest in developmental biology. Ion-channel-regulated bioelectric signals have emerged player of mechanism, which may interact with morphogens. Evidence from multiple model organisms reveals roles bioelectricity embryonic development, regeneration, cancers. The Zebrafish second most used vertebrate model, next to mouse model. zebrafish has great potential elucidating functions due many advantages external transparent early embryogenesis, tractable genetics. Here, we review genetic evidence mutants fin-size pigment changes related ion channels bioelectricity. In addition, cell membrane voltage reporting chemogenetic tools that already been or be implemented models. Finally, new perspectives opportunities research are discussed.
Язык: Английский
Процитировано
8
Advanced Science, Год журнала: 2024, Номер 11(20)
Опубликована: Март 25, 2024
Abstract Most animal cell types are classified as non‐excitable because they do not generate action potentials observed in excitable cells, such neurons and muscle cells. Thus, resolving voltage signals cells demands sensors with exceptionally high sensitivity. In this study, the ultrabright, ultrasensitive, calibratable genetically encoded sensor rEstus is developed using structure‐guided engineering. most sensitive resting range of offers a 3.6‐fold improvement brightness change for fast spikes over its precursor ASAP3. Using rEstus, it uncovered that membrane several lines (A375, HEK293T, MCF7) undergoes spontaneous endogenous alterations on second to millisecond timescale. Correlation analysis these optically recorded provides direct, real‐time readout electrical cell–cell coupling, showing visually connected A375 HEK293T also largely electrically connected, while MCF7 only weakly coupled. The presented work enhanced tools methods non‐invasive imaging living demonstrates limited but occur variety types.
Язык: Английский
Процитировано
3
Computers in Biology and Medicine, Год журнала: 2024, Номер 180, С. 108964 - 108964
Опубликована: Авг. 5, 2024
Morphogenetic regulation during embryogenesis and regeneration rely on information transfer coordination between different regions. Here, we explore theoretically the coupling bioelectrical transcriptional oscillations at individual cell multicellular levels. The simulations, based a set of ion channels intercellular gap junctions, show that waves can electrophysiologically couple distant regions model network in phase antiphase oscillatory states include synchronization phenomena. In this way, regionalizations be encoded by potentials oscillate depolarized polarized states, thus allowing spatio-temporal coding. Because electric potential patterns characteristic development are correlated with spatial distributions signaling ions molecules, bioelectricity act as template for slow biochemical signals following hierarchy experimental times. particular, gradients to transcription rates give each single rough idea its location ensemble, controlling local differentiation processes switch off crucial parts genome.
Язык: Английский
Процитировано
2
Communications Biology, Год журнала: 2024, Номер 7(1)
Опубликована: Окт. 7, 2024
Intestinal smooth muscle differentiation is a complex physico-biological process involving several different pathways. Here, we investigate the properties of Ca
Язык: Английский
Процитировано
2
Cells, Год журнала: 2024, Номер 13(13), С. 1136 - 1136
Опубликована: Июль 2, 2024
Bioelectric signals possess the ability to robustly control and manipulate patterning during embryogenesis tissue-level regeneration. Endogenous local global electric fields function as a spatial ‘pre-pattern’, controlling cell fates tissue-scale anatomical boundaries; however, mechanisms facilitating these robust multiscale outcomes are poorly characterized. Computational modeling addresses need predict in vitro behavior further elucidate roles of cellular bioelectric signaling components outcomes. Here, we modified previously designed image pattern recognition algorithm distinguish unique features simulated non-excitable patterns under distinct culture conditions. This was applied comparisons between experimental microscopy images membrane potential (Vmem) across cultured human iPSC colonies. Furthermore, extended prediction novel co-culture condition which sub-populations possessing different ionic fluxes were simulated; defining recapitulated with genetically These results collectively inform strategies for characteristics that emerge multicellular systems, characterizing molecular contributions heterogeneity cells, enabling downstream engineered bioelectrical tissue design.
Язык: Английский
Процитировано
1
International Journal of Hyperthermia, Год журнала: 2024, Номер 41(1)
Опубликована: Июль 17, 2024
There is an ongoing scientific discussion, that anti-cancer effects induced by radiofrequency (RF)-hyperthermia might not be solely attributable to subsequent temperature elevations at the tumor site but also non-temperature-induced effects. The exact molecular mechanisms behind said potential non-thermal RF remain largely elusive, however, limiting their therapeutical targetability.
Язык: Английский
Процитировано
1