None DOI Open Access
Rosarita Nasso, Antônio Alberto D'Errico, Mariorosario Masullo

и другие.

Journal of Physical Education and Sport, Год журнала: 2022, Номер 22(7)

Опубликована: Июль 31, 2022

Physical activity combined with a polyphenols rich diet have been recently emerged as non-pharmacological approach able to prevent and/or ameliorate symptoms that are related the disfunctions of energy-related health processes, in particular during aging.In this article we first described key role mitochondrial functions energy production systems activated different types physical activity.Then, reported some relevant and recent aspects concerning aging-related involved several human diseases, providing an overview most vivo vitro studies.These studies aimed identification molecular mechanisms causing including DNA mutations, radical oxygen species (ROS) generation oxidative stress, led sarcopenia.These results explored major approaches used for prevention treatments diseases.In particular, highlighted effects exercise plant on function aerobic mechanism ATP synthesis.In fact, secretion myokines from contracting skeletal muscle allows modulation various metabolic processes can improve mitochondria cell bioenergetic functions.Polyphenol intake has shown counteract alterations inflammation therefore describe these molecules, also pure form, food integration, summarized their functions.Finally, reviewed state art strategies focusing both polyphenols-rich based humans aim diseases.

Язык: Английский

Regulating Sirtuin 3-mediated mitochondrial dynamics through vanillic acid improves muscle atrophy in cancer-induced cachexia DOI Creative Commons
Gahee Song, Jinbong Park,

Yunu Jung

и другие.

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Апрель 9, 2025

Cancer cachexia is a cancer-associated disease characterized by gradual body weight loss due to pathologic muscle and fat loss, but effective treatments are still lacking. Here, we investigate the possible effect of vanillic acid (VA), known for its antioxidant, anti-inflammatory, anti-obesity effects, on mitochondria-mediated improvement cancer cachexia. We utilized cachexia-like models using CT26 colon dexamethasone. VA improved representative parameters including increased serum intereukin-6 levels. also attenuated in tibialis anterior gastrocnemius muscles, inhibited proteolytic markers RING-finger protein-1 (MURF1) atrophy F-box (MAFbx) mitochondrial function through alteration sirtuins 3 (SIRT3) mitofusin 1 (MFN1). Importantly, silencing SIRT3 gene abolished VA, indicating that important mechanism action VA. Overall, suggest as novel therapeutic agent can fundamentally treat recover patients.

Язык: Английский

Процитировано

0
Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish DOI Creative Commons

Chen‐Chen Sun,

Zhanglin Chen, Dong Kwon Yang

и другие.

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2025, Номер 16(2)

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Muscle-Derived Mitochondria as a Novel Therapy for Muscle Degeneration After Rotator Cuff Tears DOI
Ding Xu,

Qing Liu,

Jingzeng Wang

и другие.

Journal of Bone and Joint Surgery, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Background: Rotator cuff tears (RCTs) commonly lead to muscle atrophy, fatty infiltration, and fibrosis, resulting in pain, weakness, impaired shoulder mobility. These pathological changes are often irreversible pose substantial treatment challenges. The aim of this study was evaluate the therapeutic potential muscle-derived mitochondria (Mito) mitigating degeneration fibrosis following RCTs. Methods: Sprague Dawley rats were assigned 3 groups: sham surgery, RCTs treated with Mito, or phosphate-buffered saline solution (PBS). Following RCTs, vivo Mito PBS treatments administered supraspinatus muscles (SSPs) immediately then biweekly for 12 weeks. Data collected on morphology, oxidative stress, mitochondrial function, macrophage phenotypes, serum inflammatory cytokines. In vitro experiments included tracking bone marrow–derived macrophages (BMDMs), characterization polarization, cytokine profiling. Results: Isolated preserved their morphology function. improved wet weight (p < 0.0001) fiber cross-sectional area while reducing infiltration 0.0001). It upregulated markers cytochrome c oxidase (COX IV) translocase outer membrane 20 (TOMM20) enhanced antioxidative activity, as shown by increased superoxide dismutase (SOD) activity 0.0001), elevated glutathione peroxidase (GSH-PX) levels = 0.038), decreased malondialdehyde (MDA) 0.0002). Mitochondrial density restored SSPs after treatment. Additionally, induced an anti-inflammatory phenotype reduced pro-inflammatory cytokines vitro. Conclusions: mitigated degeneration, fostered environment through modulation, demonstrating its a cell-free strategy RCT-related pathologies. Clinical Relevance: Although is preclinical study, approach offers novel avenue improving RCT outcomes. However, further validation large animal models needed address translational applicability these findings, given inherent regenerative capacity rodent muscles.

Язык: Английский

Процитировано

0
New perspective on mechanism of L-arginine in promoting skeletal muscle growth of grass carp (Ctenopharyngodon Idella): Via enhancing skeletal muscle functions and regulating energy metabolism DOI
Qiuyan Chen, Yulong Ma,

Wei‐Dan Jiang

и другие.

Aquaculture, Год журнала: 2025, Номер unknown, С. 742636 - 742636

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Evaluation of muscle quality and movement-related traits in two common carp strains under a rice–fish farming system DOI

Yating Gong,

Mingkun Luo,

Xianbo Zhang

и другие.

Aquaculture International, Год журнала: 2025, Номер 33(4)

Опубликована: Май 2, 2025

Язык: Английский

Процитировано

0
Antibacterial activity of SnO2 in visible light enhanced by erbium–cobalt co-doping DOI

Xingkun Liang,

Rong Dai,

Qisheng Wang

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2023, Номер 676, С. 132257 - 132257

Опубликована: Авг. 18, 2023

Язык: Английский

Процитировано

6
Regimen on Dnaja3 haploinsufficiency mediated sarcopenic obesity with imbalanced mitochondrial homeostasis and lipid metabolism DOI Creative Commons

Yu‐Ning Fann,

Wan‐Huai Teo,

Hsin‐Chen Lee

и другие.

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 15(5), С. 2013 - 2029

Опубликована: Авг. 12, 2024

Sarcopenic obesity is characterized by excess fat mass and diminished muscular mass/function. DNAJA3, a mitochondrial co-chaperone protein, plays crucial role in skeletal muscle development. GMI, an immunomodulatory promotes myogenic differentiation through DNAJA3 activation. This study aims to elucidate the physiological effects of Dnaja3 haploinsufficiency on dysfunction dysregulated lipid metabolism assess efficacy GMI rescuing sarcopenic both vitro vivo.

Язык: Английский

Процитировано

1
Unveiling Cellular Secrets: Illuminating Carbon Dot Lighthouses for Improved Mitochondrial Exploration DOI

Sathyaprakash Kumarasamy,

Vinay Sharma

Chemistry of Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Язык: Английский

Процитировано

1
Research on the Application of Isotope Ratio Mass Spectrometry Technology in Traceability Detection of Stimulants DOI Open Access

Yue Zhuo,

Yirang Wang,

Xiaomeng Xiang

и другие.

Journal of engineering system., Год журнала: 2024, Номер 2(1), С. 75 - 82

Опубликована: Март 1, 2024

Endogenous substances, which are produced by the body itself, have become a focus of concern due to their potential abuse as stimulants in sports. The chemical structure and physicochemical properties externally synthesized endogenous substances similar those internally, making them difficult detect. In response this challenge, it is crucial develop effective methods for detecting both exogenous substances. One promising approach leverages differences stable carbon isotope abundance between internal external sources, leading changes Compound-Specific Isotope Ratio (CIR) after ingestion. GC-C-IRMS method has emerged commonly used highly accurate technique tracing origin Recognizing its significance fight against doping, World Anti-Doping Agency (WADA) standardized established relevant benchmarks. This review article examines advancements made over past decade S1 anabolic steroids, S4 hormones metabolic modulators, S9 glucocorticoids. By offering comprehensive overview progress detection using ratio mass spectrometry, aim provide valuable insights enhancing existing anti-doping measures. research serves critical reference point ongoing efforts combat misuse realm

Язык: Английский

Процитировано

0
Metabolic differences in MSTN and FGF5 dual-gene edited sheep muscle cells during myogenesis DOI Creative Commons
Mingming Chen, Yan Li,

Xueling Xu

и другие.

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Июнь 26, 2024

Abstract Dynamic metabolic reprogramming occurs at different stages of myogenesis and contributes to the fate determination skeletal muscle satellite cells (MuSCs). Accumulating evidence suggests that mutations in myostatin (MSTN) have a vital role regulating energy metabolism. Here, we explored MuSCs myotube MSTN FGF5 dual-gene edited sheep models prepared previously, also focused on alterations during myogenic differentiation MuSCs. Our study revealed pathways nucleotide metabolism, pantothenate CoA biosynthesis were weakened, while unsaturated fatty acids strengthened The editing mainly inhibited metabolism MuSCs, reduced number lipid droplets per cell, promoted pentose phosphate pathway, interconversion glucuronate. resulted inhibition TCA cycle pathway differentiated cells. differential metabolites identified can be characterized as biomarkers cellular states, providing new reference for regulation development. It may provide development regeneration drugs targeting biomarkers.

Язык: Английский

Процитировано

0