Journal of Leukocyte Biology,
Год журнала:
2023,
Номер
115(1), С. 85 - 99
Опубликована: Авг. 24, 2023
COVID-19
emerged
in
September
2020
as
a
disease
caused
by
the
virus
SARS-CoV-2.
The
presented
pneumonia
at
first
but
later
was
shown
to
cause
multisystem
infections
and
long-term
complications.
Many
efforts
have
been
put
into
discovering
exact
pathogenesis
of
disease.
In
this
review,
we
aim
discuss
an
emerging
tool
modeling,
organoids,
investigation
COVID-19.
This
review
will
introduce
some
methods
breakthroughs
achieved
organoids
limitations
system.
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(48), С. 19223 - 19235
Опубликована: Ноя. 7, 2023
Insights
into
how
biological
systems
respond
to
high-
and
low-dose
acute
environmental
stressors
are
a
fundamental
aspect
of
exposome
research.
However,
studying
the
impact
low-level
exposure
in
conventional
vitro
settings
is
challenging.
This
study
employed
three-dimensional
(3D)
biomimetic
microfluidic
lung-on-chip
(μLOC)
platform
RNA-sequencing
examine
effects
two
model
anthropogenic
engineered
nanoparticles
(NPs):
zinc
oxide
(Nano-ZnO)
copier
center
(Nano-CCP).
The
airway
epithelium
exposed
these
NPs
exhibited
dose-dependent
increases
cytotoxicity
barrier
dysregulation
(dominance
external
exposome).
Interestingly,
even
nontoxic
(10
μg/mL)
compartment
Nano-ZnO
triggered
chemotaxis
lung
fibroblasts
toward
epithelium.
An
increase
α
smooth
muscle
actin
(α-SMA)
expression
contractile
activity
was
also
observed
cells,
indicating
bystander-like
adaptive
response
internal
Further
bioinformatics
network
analysis
showed
that
significantly
induced
robust
transcriptomic
upregulated
several
hub
genes
associated
with
development
fibrosis.
We
propose
Nano-ZnO,
at
no
observable
effect
level
(NOEL)
dose
according
standards,
can
function
as
potent
nanostressor
disrupt
homeostasis.
leads
cascade
profibrotic
events
cross-tissue
fashion.
Our
findings
offer
new
insights
early
respiratory
harm
exposure,
paving
way
for
better
exposomic
understanding
this
emerging
class
nanopollutants.
Environmental Science Processes & Impacts,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
In
recent
decades,
several
cell-based
and
acellular
methods
have
been
developed
to
evaluate
ambient
particulate
matter
(PM)
toxicity.
Although
provide
a
more
comprehensive
assessment
of
PM
toxicity,
their
results
are
difficult
comprehend
due
the
diversity
in
cellular
endpoints,
cell
types,
assays
interference
chemical
components
with
some
assays'
techniques.
this
review,
we
attempt
clarify
these
issues.
We
first
discuss
morphological
immunological
differences
among
various
macrophage
epithelial
cells,
belonging
respiratory
systems
human
murine
species,
used
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(11), С. 1531 - 1552
Опубликована: Ноя. 2, 2023
Introduction
Numerous
delivery
strategies,
primarily
novel
nucleic
acid
carriers,
have
been
developed
and
explored
to
enable
therapeutically
relevant
lung
gene
therapy.
However,
its
clinical
translation
is
yet
be
achieved
despite
over
30
years
of
efforts,
which
attributed
the
inability
overcome
a
series
biological
barriers
that
hamper
efficient
transfer
target
cells
in
lung.
Journal of Leukocyte Biology,
Год журнала:
2023,
Номер
115(1), С. 85 - 99
Опубликована: Авг. 24, 2023
COVID-19
emerged
in
September
2020
as
a
disease
caused
by
the
virus
SARS-CoV-2.
The
presented
pneumonia
at
first
but
later
was
shown
to
cause
multisystem
infections
and
long-term
complications.
Many
efforts
have
been
put
into
discovering
exact
pathogenesis
of
disease.
In
this
review,
we
aim
discuss
an
emerging
tool
modeling,
organoids,
investigation
COVID-19.
This
review
will
introduce
some
methods
breakthroughs
achieved
organoids
limitations
system.