Metabolomics in vitreous fluid of retinal detachment associated with choroidal detachment patients DOI Creative Commons

Lufei Yang,

Shasha Luo,

Yanghao Chen

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Апрель 5, 2023

Abstract Background Rhegmatogenous retinal detachment associated with choroidal (RRDCD) is a complex type of detachment. This disease characterized by high difficulty operation and poor prognosis. However, the pathogenesis still unclear. The purpose this study was to analyze changes metabolites metabolic pathways in vitreous fluid RRDCD patients. Method Using ultra-high-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry method, idiopathic epimacular membrane (IEMM) patients were analyzed. A total 28 samples analyzed compare significance different between these groups. Results We identified 135 IEMM groups (VIP > 1, P value < 0.05). Compared group, level sphingomyelin, adenosine, L-palmitoylcarnitine 4,7,10,13,1 6,19-docosahexaenoic acid up-regulated group. series lipid main involved protein digestion absorption, ABC transporters, aminoacyl-tRNA biosynthesis, central carbon metabolism cancer sphingolipids metabolism. Conclusions Our results suggest that up-regulation sphingomyelin abnormal may induce cell migration death after or And then, it intraocular inflammation damage visual function. accumulated fatty energy pathway retina, aggravate photoreceptors hypoxia. These provide clues for studying mechanism, treatment prognosis RRDCD.

Язык: Английский

Identifying the key role of mitochondrial respiration and lipid metabolism in regulating axillary osmidrosis through proteomics analysis DOI
Qiong Gao, Yuxin Liu, Jie Huang

и другие.

Archives of Dermatological Research, Год журнала: 2024, Номер 317(1)

Опубликована: Дек. 14, 2024

Язык: Английский

Процитировано

0
Metabolomics in vitreous fluid of retinal detachment associated with choroidal detachment patients DOI Creative Commons

Lufei Yang,

Shasha Luo,

Yanghao Chen

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Апрель 5, 2023

Abstract Background Rhegmatogenous retinal detachment associated with choroidal (RRDCD) is a complex type of detachment. This disease characterized by high difficulty operation and poor prognosis. However, the pathogenesis still unclear. The purpose this study was to analyze changes metabolites metabolic pathways in vitreous fluid RRDCD patients. Method Using ultra-high-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry method, idiopathic epimacular membrane (IEMM) patients were analyzed. A total 28 samples analyzed compare significance different between these groups. Results We identified 135 IEMM groups (VIP > 1, P value < 0.05). Compared group, level sphingomyelin, adenosine, L-palmitoylcarnitine 4,7,10,13,1 6,19-docosahexaenoic acid up-regulated group. series lipid main involved protein digestion absorption, ABC transporters, aminoacyl-tRNA biosynthesis, central carbon metabolism cancer sphingolipids metabolism. Conclusions Our results suggest that up-regulation sphingomyelin abnormal may induce cell migration death after or And then, it intraocular inflammation damage visual function. accumulated fatty energy pathway retina, aggravate photoreceptors hypoxia. These provide clues for studying mechanism, treatment prognosis RRDCD.

Язык: Английский

Процитировано

0