bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 5, 2023
The
ability
to
alter
gene
expression
programs
in
response
changes
environmental
conditions
is
central
the
of
an
organism
thrive.
For
most
organisms,
nervous
system
serves
as
master
regulator
communicating
information
about
animal's
surroundings
other
tissues.
relay
centers
on
signaling
pathways
that
cue
transcription
factors
a
given
cell
type
execute
specific
program,
but
also
provide
means
signal
between
factor
PQM-1
important
mediator
insulin
pathway
contributing
longevity
and
stress
well
impacting
survival
from
hypoxia.
Herein,
we
reveal
novel
mechanism
for
regulating
specifically
neural
cells
larval
animals.
Our
studies
RNA
binding
protein,
ADR-1,
binds
pqm-1
mRNA
cells.
This
regulated
by
presence
second
ADR-2,
which
when
absent
leads
reduced
both
downstream
activated
genes.
Interestingly,
find
sufficient
impact
throughout
animal
affect
hypoxia;
phenotypes
observe
adr
mutant
Together,
these
post-transcriptional
regulatory
allows
sense
respond
promote
organismal
Brain Behavior and Immunity,
Год журнала:
2023,
Номер
115, С. 229 - 247
Опубликована: Окт. 18, 2023
Childhood
is
recognised
as
a
period
of
immense
physical
and
emotional
development,
this,
in
part,
driven
by
underlying
neurophysiological
transformations.
These
neurodevelopmental
processes
are
unique
to
the
paediatric
brain
facilitated
augmented
rates
neuroplasticity
expanded
neural
stem
cell
populations
within
neurogenic
niches.
However,
given
immaturity
developing
central
nervous
system,
innate
protective
mechanisms
such
neuroimmune
antioxidant
responses
functionally
naïve
which
results
periods
heightened
sensitivity
neurotoxic
insult.
This
highly
relevant
context
cancer,
particular,
neurocognitive
symptoms
associated
with
treatment,
surgery,
radio-
chemotherapy.
The
vulnerability
may
increase
susceptibility
damage
persistent
symptomology,
aligning
reports
more
severe
dysfunction
children
compared
adults.
It
therefore
surprising,
this
intensified
burden,
that
most
pre-clinical,
mechanistic
research
focuses
exclusively
on
adult
extrapolates
findings
cohorts.
Given
dearth
age-specific
research,
throughout
review
we
will
draw
comparisons
disorders
share
comparable
pathways
cancer
treatment
related
side-effects.
Furthermore,
examine
nuances
along
somatic
systems
influence
neurological
function.
In
doing
so,
highlight
importance
vitro
vivo
disease
models
produce
discovery
clinically
translatable
research.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 2, 2024
Earlier
observational
studies
have
demonstrated
a
correlation
between
glioma
and
the
risk
of
neurodegenerative
diseases
(NDs),
but
causality
direction
their
associations
remain
unclear.
The
objective
this
study
was
to
ascertain
causal
link
NDs
using
Mendelian
randomization
(MR)
methodology.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 5, 2023
The
ability
to
alter
gene
expression
programs
in
response
changes
environmental
conditions
is
central
the
of
an
organism
thrive.
For
most
organisms,
nervous
system
serves
as
master
regulator
communicating
information
about
animal's
surroundings
other
tissues.
relay
centers
on
signaling
pathways
that
cue
transcription
factors
a
given
cell
type
execute
specific
program,
but
also
provide
means
signal
between
factor
PQM-1
important
mediator
insulin
pathway
contributing
longevity
and
stress
well
impacting
survival
from
hypoxia.
Herein,
we
reveal
novel
mechanism
for
regulating
specifically
neural
cells
larval
animals.
Our
studies
RNA
binding
protein,
ADR-1,
binds
pqm-1
mRNA
cells.
This
regulated
by
presence
second
ADR-2,
which
when
absent
leads
reduced
both
downstream
activated
genes.
Interestingly,
find
sufficient
impact
throughout
animal
affect
hypoxia;
phenotypes
observe
adr
mutant
Together,
these
post-transcriptional
regulatory
allows
sense
respond
promote
organismal
