Proceedings of the Shevchenko Scientific Society Medical Sciences,
Год журнала:
2023,
Номер
72(2)
Опубликована: Дек. 22, 2023
Infertility
is
a
major
medical
and
social
issue.
In
vitro
fertilization
an
advanced
ART
technique
that
helps
to
successfully
cure
infertility.
Quality
preparation
for
IVF
protocol
the
subsequent
pregnancy
important
should
include
treatment
of
concomitant
pathology,
evaluation
condition
uterine
cavity
its
optimal
in
order
prevent
reproductive
failures
early
obstetric
losses.
This
study
assessed
effectiveness
optimized
cryoprotocols
embryo
transfer
patients
with
infertility
comorbid
course
leiomyoma
chronic
endometritis.
We
performed
clinical
examination
comparative
analysis
anamnestic
data
100
women
The
were
divided
into
two
groups
depending
on
proposed
scheme
outcomes
compared
control
group.
all
groups,
stimulation
superovulation
was
carried
out
following
short
GnRH
antagonist.
determined
endometritis,
when
group
patients,
had
history
menarche,
onset
sexual
life,
greater
number
partners,
incidence
urogenital
infections,
intrauterine
surgical
procedures.
modified
received
lower
mean
total
dose
gonadotropins,
shorter
duration
stimulation,
fewer
days
anti-GnRH
administration
traditional
also
higher
frequency
delivery
those
conventional
treatment.
An
appropriate
anti-inflammatory
antibiotic
therapy
comprehensive
are
key
factors
success
protocols.
Human Reproduction Update,
Год журнала:
2024,
Номер
30(5), С. 584 - 613
Опубликована: Май 25, 2024
Abstract
BACKGROUND
The
establishment
and
maintenance
of
pregnancy
depend
on
endometrial
competence.
Asherman
syndrome
(AS)
intrauterine
adhesions
(IUA),
or
atrophy
(EA)
thin
endometrium
(TE),
can
either
originate
autonomously
arise
as
a
result
from
conditions
(i.e.
endometritis
congenital
hypoplasia),
medical
interventions
(e.g.
surgeries,
hormonal
therapies,
uterine
curettage
radiotherapy).
Affected
patients
may
present
an
altered
inadequate
lining
that
hinders
embryo
implantation
increases
the
risk
poor
outcomes
miscarriage.
In
humans,
AS/IUA
EA/TE
are
mainly
treated
with
surgeries
pharmacotherapy,
however
reported
efficacy
these
therapeutic
approaches
remains
unclear.
Thus,
novel
regenerative
techniques
utilizing
stem
cells,
growth
factors,
tissue
engineering
have
emerged
to
improve
reproductive
outcomes.
OBJECTIVE
AND
RATIONALE
This
review
comprehensively
summarizes
methodologies
emerging
biotechnologies
(cellular,
acellular,
bioengineering
approaches)
treat
human
pathologies.
Regenerative
therapies
derived
tissues
blood
which
were
studied
in
preclinical
models
(in
vitro
vivo)
clinical
trials
discussed.
SEARCH
METHODS
A
systematic
search
full-text
articles
available
PubMed
Embase
was
conducted
identify
original
peer-reviewed
studies
published
English
between
January
2000
September
2023.
terms
included:
human,
uterus,
endometrium,
syndrome,
adhesions,
atrophy,
endometritis,
hypoplasia,
curettage,
radiotherapy,
therapy,
bioengineering,
vesicles,
platelet-rich
plasma,
biomaterials,
microfluidic,
bioprinting,
organoids,
hydrogel,
scaffold,
sheet,
miRNA,
sildenafil,
nitroglycerine,
aspirin,
hormone,
progesterone,
estrogen.
Preclinical
cellular,
strategies
repair
regenerate
included.
Additional
identified
through
manual
searches.
OUTCOMES
From
total
4366
records
identified,
164
(3.8%)
included
for
review.
Due
heterogeneity
study
design
measured
outcome
parameters
both
studies,
findings
evaluated
qualitatively
quantitatively
without
meta-analysis.
Groups
using
cell-based
treatments
pathologies
commonly
employed
mesenchymal
cells
(MSCs)
bone
marrow
umbilical
cord.
Alternatively,
acellular
based
plasma
(PRP)
extracellular
vesicles
gaining
popularity.
These
accompanied
by
emergence
matrix
(ECM)-derived
hydrogels
synthetic
biosimilars
sustain
local
delivery
reporting
promising
results.
Combined
target
multiple
aspects
regeneration
remain
testing
but
shown
translational
value.
highlights
myriad
material
sources,
administration
methods,
carriers
been
tested.
WIDER
IMPLICATIONS
Therapies
promote
proliferation,
vascular
development,
help
restore
function
and,
ultimately,
fertility.
Based
existing
evidence,
cost,
accessibility,
availability
we
propose
development
triple-hit
strategies,
potentially
combining
high-yield
MSCs
cord)
(PRP),
possibly
integrated
ECM
hydrogels.
Advances
together
insights
will
pave
way
developing
personalized
treatment
regimens
infertility-causing
disorders
such
AS/IUA,
EA/TE,
endometritis.
REGISTRATION
NUMBER
https://osf.io/th8yf/
Biomedicines,
Год журнала:
2023,
Номер
11(6), С. 1714 - 1714
Опубликована: Июнь 15, 2023
Chronic
endometritis
(CE)
is
the
persistent
inflammation
of
endometrial
lining
associated
with
infertility
and
various
forms
reproductive
failures.
The
diagnosis
CE
based
on
histological
evidence
stromal
plasma
cells;
however,
standardized
methods
to
assess
cells
are
still
lacking.
In
present
paper,
we
aimed
determine
most
appropriate
cell
threshold
diagnose
pregnancy
outcomes.
Three
electronic
databases
were
searched
from
their
inception
February
2022
for
all
studies
comparing
outcomes
between
patients
without
CE.
relative
risk
(RR)
pregnancy,
miscarriage,
and/or
live
birth
rates
calculated
pooled
adopted.
A
p-value
<
0.05
was
considered
significant.
Nine
adopting
different
thresholds
(1
50
cells/10
HPF)
included.
meta-analysis,
only
found
a
significant
association
miscarriage
rate
count
≥
5/10
HPF
(RR
=
2.4;
p
0.007).
Among
not
suitable
showed
an
worsened
when
high
(10
50/10
conclusion,
our
study
suggests
that
presence
at
low
levels
(<5/10
may
predict
Based
these
findings,
≥5
be
more
Medicina,
Год журнала:
2024,
Номер
60(6), С. 972 - 972
Опубликована: Июнь 12, 2024
Chronic
endometritis
(CE)
is
an
inflammatory
pathologic
condition
of
the
uterine
mucosa
characterized
by
unusual
infiltration
CD138(+)
endometrial
stromal
plasmacytes
(ESPCs).
CE
often
identified
in
infertile
women
with
unexplained
etiology,
tubal
factors,
endometriosis,
repeated
implantation
failure,
and
recurrent
pregnancy
loss.
Diagnosis
has
traditionally
relied
on
biopsy
histopathologic/immunohistochemistrical
detection
ESPCs.
Endometrial
biopsy,
however,
a
somewhat
painful
procedure
for
subjects
does
not
allow
us
to
grasp
whole
picture
this
mucosal
tissue.
Meanwhile,
fluid
hysteroscopy
been
recently
adopted
as
less-invasive
diagnostic
modality
CE.
We
launched
ARCHIPELAGO
(ARChival
Hysteroscopic
Image-based
Prediction
histopathologic
chronic
Endometritis
using
deep
LeArninG
mOdel)
study
construct
hysteroscopic
finding-based
prediction
tools
The
development
these
learning-based
novel
models
computer-aided
detection/diagnosis
systems
potentially
benefits
suffering
from
elusive
disease.
BMC Women s Health,
Год журнала:
2023,
Номер
23(1)
Опубликована: Июнь 30, 2023
Abstract
Background
The
aim
of
this
retrospective
study
was
to
investigate
whether
oral
antibiotics
(doxycycline
and
metronidazole)
combined
with
intrauterine
perfusion
(gentamicin
dexamethasone)
are
beneficial
for
patients
repeated
implantation
failure
(RIF)
chronic
endometritis
(CE)
improve
clinical
pregnancy
outcomes.
Methods
Patients
RIF
CE
were
diagnosed
using
hysteroscopy
histology
together.
A
total
42
enrolled
in
the
study.
All
received
22
underwent
immediately
after
end
antibiotic
therapy.
Pregnancy
outcomes
evaluated
during
first
vitro
fertilization
(IVF)
embryo
transfer
(ET)
cycle.
Results
For
D3
ET
treatment
dexamethasone),
higher
rate
(30.95%
vs.
26.67%,
P
=
0.0308),
(30%
50%,
<
0.001),
live
birth
(33.33%
45.45%,
0.0001).
No
fetal
malformations
or
ectopic
pregnancies
observed.
Conclusion
We
report
as
a
novel
successful
compared
those
alone.
Reproductive Health,
Год журнала:
2024,
Номер
21(1)
Опубликована: Ноя. 14, 2024
Endometriosis
(EMS)
and
chronic
endometritis
(CE)
frequently
coexist.
This
study
aimed
to
examine
the
impact
of
CE
on
reproductive
outcomes
in
patients
with
EMS.
We
enrolled
685
endometriosis-associated
infertility
from
January
2018
December
2020.
The
were
divided
into
(318)
non-CE
(367)
groups.
A
subset
123
clinically
pregnant
women
group
369
was
selected
for
detailed
comparison.
Pregnancy
delivery
data
meticulously
collected
hospital
records
through
telephone
interviews.
diagnosed
46.42%
EMS
patients.
Higher
pregnancy
rates
observed
Fertility
Index
(EFI)
scores
7–10.
had
increased
risks
placenta
previa
(13.01%),
gestational
hypertension
(5.69%),
cesarean
sections
(59.34%).
CE,
which
is
prevalent
among
patients,
linked
complications,
including
previa,
hypertension,
delivery.
Although
combined
hysteroscopy
laparoscopy
improve
rates,
they
demand
careful
management
these
complications.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 25, 2024
AbstractBackground:
Endometriosis
(EMS)
and
chronic
endometritis
(CE)
often
coexist.
Laparoscopic
hysteroscopic
surgery
is
one
of
the
main
methods
for
diagnosing
treating
these
conditions.
The
objectives
this
study
were
to
examine
clinical
characteristics
prognosis
surgically
diagnosed
EMS
complicated
by
CE
assess
reproductive
outcomes
during
subsequent
pregnancies.
Methods:A
total
1574
infertile
patients
included
in
between
January
2018
December
2020.
685
with
endometriosis
who
further
divided
into
two
groups:
a
group
consisting
318
non-CE
367
patients.
Within
cohort
suffered
from
CE,
subset
postoperative
care
pregnant
women
(n=123)
was
selected
form
group.
control
consisted
undergoing
singleton
pregnancy
(n=369)
underwent
delivery
same
period.
Data
on
statuses
complications
collected
hospitals
through
telephone
interviews.
Results:
prevalence
rate
46.42%.
Among
posterior
135
achieved
pregnancy.
cumulative
found
be
significantly
higher
groups
fertility
index
(EFI)
scores
ranging
7
8
9
10
compared
EFI
below
7.
Furthermore,
both
had
risk
experiencing
pregnancy,
including
placenta
previa
(13.01%),
gestational
hypertension
(5.69%),
cesarean
section
(59.34%).
Conclusions:Patients
exhibited
heightened
endometritis.
Our
investigation
revealed
that
combined
laparoscopic
proved
successful
approach
augmenting
overall
rate.
afflicted
face
an
independently
escalated
susceptibility
previa,
hypertension,
delivery.
