Applied Sciences,
Год журнала:
2024,
Номер
14(24), С. 12051 - 12051
Опубликована: Дек. 23, 2024
Aging
affects
the
structure
and
functions
of
all
organs
systems
in
organism.
In
elderly,
significant
changes
hormonal
levels
are
observed.
These
translate
to
a
predisposition
for
chronic
diseases,
including
cardiovascular,
neurodegenerative,
metabolic
disorders.
Therefore,
tremendous
scientific
effort
is
focused
on
investigating
molecular
mechanisms
drugs
with
potential
reduce
old
age
their
impact.
Sirtuin
1
(SIRT1),
member
sirtuin
family
deacetylases,
has
been
extensively
studied
as
regulator
multiple
pathways
related
antioxidant
properties,
optimal
immune
response,
metabolism.
SIRT1
plays
key
role
regulating
various
maintaining
homeostasis.
present
study,
we
review
interplay
between
regulations,
endocrine
hypothalamic–pituitary–thyroid,
–adrenal,
–gonadal,
–liver
axes,
other
glands,
non-endocrine
tissues
aging
The
application
natural
activators,
such
resveratrol,
curcumin,
paeonol,
Buyang
Huanwu
Decoction,
treatment
senescence
discussed.
activators
improve
mitochondrial
function,
oxidative
stress,
promote
longevity,
but
clinical
limited
by
low
bioavailability
poor
permeability
across
biological
barriers.
For
this
reason,
advanced
delivery
strategies
being
considered,
nose-to-brain
drug
nanotechnology-based
formulations.
Biocell,
Год журнала:
2024,
Номер
48(10), С. 1405 - 1418
Опубликована: Янв. 1, 2024
Degeneration
and
death
of
nerve
cells
are
inevitable
with
the
occurrence
progression
nervous
system
disorders.Researchers
transplanted
neural
stem
into
relevant
areas,
trying
to
solve
difficulty
cell
loss
by
differentiating
various
cells.In
recent
years,
however,
studies
have
shown
that
help
tissues
regenerate
return
normal
through
paracrine
action
rather
than
just
replacing
cells.Exosomes
essential
mediators,
which
can
participate
in
communication
substance
transmission.In
this
regard,
review
mainly
discusses
current
research
progress
cell-derived
exosomes.This
paper
introduces
self-regulation
(NSCs)-derived
exosomes
on
clarify
role
NSCs-derived
system;
therapeutic
effect
neurological
diseases;
different
exosomes,
showing
more
in-depth
results
exosomes.It
presents
some
ideas
provide
a
reference
for
subsequent
exosomes.
Medicine,
Год журнала:
2024,
Номер
103(36), С. e39498 - e39498
Опубликована: Сен. 6, 2024
Exosomes,
which
are
extracellular
vesicles
secreted
and
released
from
specific
cells,
exist
widely
in
cell
culture
supernatants
various
body
fluids.
This
study
aimed
to
analyze
the
research
status
of
exosomes
stroke,
predict
developmental
trends
via
bibliometric
analyses.
The
related
literature
January
1,
2008
2024
was
searched
Web
Science
Core
Collection
943
articles
were
retrieved.
VOSviewer
used
visualize
national
cooperation
institutional
cooperation.
Cluster
analysis
keywords
Citespace
applied
for
mutation
analysis.
Results:
works
showed
that
number
published
has
been
steadily
increasing
since
2015.
It
is
predicted
nearly
211
will
be
220
annually
by
2028.
China
largest
publications
(473),
followed
United
States
(234),
Germany
(61).
institution
with
most
Henry
Ford
Hospital
(Detroit,
MI).
In
keyword
cluster
“Exosomes
Mechanism
Stroke:
Inflammation
Apoptosis,”
inflammation
identified
as
hotspots.
“Functional
recovery”
a
new
trend
“Angiogenesis
Functional
Recovery
after
Stroke.”
main
forces
this
field,
both
countries
focusing
on
drug
treatments.
studies
have
mainly
States.
findings
our
analyses
may
enable
researchers
choose
appropriate
institutions,
collaborators,
journals.
Applied Sciences,
Год журнала:
2024,
Номер
14(24), С. 12051 - 12051
Опубликована: Дек. 23, 2024
Aging
affects
the
structure
and
functions
of
all
organs
systems
in
organism.
In
elderly,
significant
changes
hormonal
levels
are
observed.
These
translate
to
a
predisposition
for
chronic
diseases,
including
cardiovascular,
neurodegenerative,
metabolic
disorders.
Therefore,
tremendous
scientific
effort
is
focused
on
investigating
molecular
mechanisms
drugs
with
potential
reduce
old
age
their
impact.
Sirtuin
1
(SIRT1),
member
sirtuin
family
deacetylases,
has
been
extensively
studied
as
regulator
multiple
pathways
related
antioxidant
properties,
optimal
immune
response,
metabolism.
SIRT1
plays
key
role
regulating
various
maintaining
homeostasis.
present
study,
we
review
interplay
between
regulations,
endocrine
hypothalamic–pituitary–thyroid,
–adrenal,
–gonadal,
–liver
axes,
other
glands,
non-endocrine
tissues
aging
The
application
natural
activators,
such
resveratrol,
curcumin,
paeonol,
Buyang
Huanwu
Decoction,
treatment
senescence
discussed.
activators
improve
mitochondrial
function,
oxidative
stress,
promote
longevity,
but
clinical
limited
by
low
bioavailability
poor
permeability
across
biological
barriers.
For
this
reason,
advanced
delivery
strategies
being
considered,
nose-to-brain
drug
nanotechnology-based
formulations.
