ACS Infectious Diseases,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis
(M.tb),
is
the
most
common
secondary
infection
in
Human
Immunodeficiency
Virus
(HIV)
infected
population,
accounting
for
more
than
one-fourth
of
deaths
people
living
with
HIV
(PLWH).
Reciprocally,
increases
susceptibility
to
primary
TB
or
reactivation
latent
several
folds.
The
synergistic
interactions
between
M.tb
and
not
only
potentiate
their
deleterious
impact
but
also
complicate
clinical
management
both
diseases.
M.tb-HIV
coinfected
patients
have
a
high
risk
failure
accurate
diagnosis,
treatment
inefficiency
HIV,
concurrent
nontuberculous
mycobacterial
infections,
other
comorbidities
such
as
diabetes
mellitus,
severe
cytotoxicity
due
drug
overburden,
immune
reconstitution
inflammatory
syndrome
(IRIS).
need
hour
understand
coinfection
biology
collective
on
host
immunocompetence
think
out-of-the-box
perspectives,
including
host-directed
therapy
under
rising
view
homeostatic
medicines.
This
review
aims
highlight
molecular
players,
from
pathogens
host,
that
facilitate
host-associated
proteins/enzymes
regulating
immunometabolism,
underlining
potential
targets
designing
screening
chemical
inhibitors
reduce
burden
concomitantly
during
coinfection.
To
appreciate
necessity
revisiting
therapeutic
approaches
research
priorities,
we
provide
glimpse
anti-TB
antiretroviral
drug-drug
interactions,
project
gaps
our
understanding
biology,
enlist
some
key
initiatives
will
help
us
deal
epidemic
Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
262, С. 108710 - 108710
Опубликована: Авг. 22, 2024
In
an
aging
society,
unveiling
new
anti-aging
strategies
to
prevent
and
combat
aging-related
diseases
is
of
utmost
importance.
Mitochondria
are
the
primary
ATP
production
sites
key
regulators
programmed
cell
death.
Consequently,
these
highly
dynamic
organelles
play
a
central
role
in
maintaining
tissue
function,
mitochondrial
dysfunction
pivotal
factor
progressive
age-related
decline
cellular
homeostasis
organ
function.
The
current
review
examines
recent
advances
understanding
interplay
between
organ-specific
aging.
Thereby,
we
dissect
molecular
mechanisms
underlying
impairment
associated
with
deterioration
exploring
DNA,
reactive
oxygen
species
homeostasis,
metabolic
activity,
damage-associated
patterns,
biogenesis,
turnover,
dynamics.
We
also
highlight
emerging
therapeutic
preclinical
clinical
tests
that
supposed
rejuvenate
such
as
antioxidants,
biogenesis
stimulators,
modulators
turnover
Furthermore,
discuss
potential
benefits
challenges
use
interventions,
emphasizing
need
for
approaches
given
unique
characteristics
different
tissues.
conclusion,
this
highlights
addressing
mitigate
aging,
focusing
on
skin,
liver,
lung,
brain,
skeletal
muscle,
well
reproductive,
immune,
cardiovascular
systems.
Based
comprehensive
multifaceted
roles
mitochondria,
innovative
may
be
developed
optimized
biological
promote
healthy
across
diverse
Cell Reports,
Год журнала:
2024,
Номер
43(2), С. 113739 - 113739
Опубликована: Фев. 1, 2024
Glucose
uptake
increases
during
B
cell
activation
and
antibody-secreting
(ASC)
differentiation,
but
conflicting
findings
prevent
a
clear
metabolic
profile
at
different
stages
of
activation.
Deletion
the
glucose
transporter
type
1
(GLUT1)
gene
in
mature
cells
(GLUT1-cKO)
results
normal
development,
it
reduces
germinal
center
ASCs.
GLUT1-cKO
mice
show
decreased
antigen-specific
antibody
titers
after
vaccination.
In
vitro,
GLUT1-deficient
impaired
activation,
whereas
established
plasmablasts
abolish
glycolysis,
relying
on
mitochondrial
activity
fatty
acids.
Transcriptomics
metabolomics
reveal
an
altered
anaplerotic
balance
Despite
attempts
to
compensate
for
deprivation
by
increasing
mass
expression
associated
with
tricarboxylic
acid
cycle,
hexosamine
synthesis,
ASCs
lack
metabolites
energy
production
respiration,
limiting
protein
synthesis.
We
identify
GLUT1
as
critical
player
defining
response
humoral
immunity.
Immunological Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 17, 2024
Summary
The
NLRP3
inflammasome
is
a
multiprotein
complex
that
upon
activation
by
the
innate
immune
system
drives
broad
inflammatory
response.
primary
initial
mediators
of
this
response
are
pro‐IL‐1β
and
pro‐IL‐18,
both
which
in
an
inactive
form.
Formation
activates
caspase‐1,
cleaves
pro‐IL‐18
triggers
formation
gasdermin
D
pores.
Gasdermin
pores
allow
for
secretion
active
IL‐1β
IL‐18
initiating
organism‐wide
can
be
beneficial
to
host;
however,
if
inappropriately
activated
it
lead
significant
pathology.
While
components
known,
precise
details
assembly
less
well
defined
conflicting.
Here,
we
discuss
several
proposed
pathways
inflammasome.
We
examine
role
subcellular
localization
reciprocal
regulation
autophagy.
focus
on
roles
mitochondria
mitophagy
activating
regulating
Finally,
detail
impact
pathologic
responses
development
manifestations
pulmonary
disease.
Journal of Biological Chemistry,
Год журнала:
2025,
Номер
unknown, С. 108252 - 108252
Опубликована: Фев. 1, 2025
Every
cell
in
the
body
is
exposed
to
a
certain
level
of
CO2
and
O2.
Hypercapnia
hypoxia
elicit
stress
signals
influence
cellular
metabolism
function.
Both
conditions
exert
profound
yet
distinct
effects
on
metabolic
pathways
mitochondrial
dynamics,
highlighting
need
for
cells
adapt
changes
gaseous
microenvironment.
The
interplay
between
hypercapnia
signalling
key
dictating
homeostasis
as
microenvironmental
O2
levels
are
inextricably
linked.
Hypercapnia,
characterized
by
elevated
pCO₂,
introduces
adaptations
within
aerobic
pathways,
affecting
TCA
cycle
flux,
lipid,
amino
acid
metabolism,
OXPHOS
ETC.
Hypoxia,
defined
reduced
oxygen
availability,
necessitates
shift
from
anaerobic
glycolysis
sustain
ATP
production,
process
orchestrated
stabilisation
HIF-1α.
Given
that
present
both
physiological
cancerous
microenvironments,
how
might
coexistence
function
niches
tumor
microenvironment?
Toxics,
Год журнала:
2024,
Номер
12(1), С. 67 - 67
Опубликована: Янв. 13, 2024
Three-dimensional
(3D)
printer
usage
in
household
and
school
settings
has
raised
health
concerns
regarding
chemical
particle
emission
exposures
during
operation.
Although
the
composition
of
3D
emissions
varies
depending
on
materials,
little
is
known
about
impact
that
from
different
filament
types
may
have
respiratory
underlying
cellular
mechanisms.
In
this
study,
we
used
an
vitro
exposure
chamber
system
to
deliver
two
popular
3D-printing
types,
acrylonitrile
butadiene
styrene
(ABS)
polylactic
acid
(PLA),
directly
human
small
airway
epithelial
cells
(SAEC)
cultured
air–liquid
interface
Using
a
scanning
mobility
sizer
(SMPS)
optical
(OPS),
monitored
particulate
matter
(PM)
terms
their
size
distribution,
concentrations,
calculated
deposited
doses.
Elemental
ABS
PLA
was
assessed
using
electron
microscopy
coupled
with
energy
dispersive
X-ray
spectroscopy
(SEM-EDX).
Finally,
compared
effects
cell
viability,
inflammation,
metabolism
SAEC.
Our
results
reveal
that,
although
filaments
emitted
higher
total
concentration
particles
smaller
particles,
SAEC
were
exposed
similar
doses
for
each
type.
Conversely,
had
distinct
elemental
compositions,
which
likely
responsible
differential
oxidative
stress,
release
inflammatory
mediators,
changes
metabolism.
Specifically,
while
ABS-
PLA-emitted
both
reduced
viability
glutathione
levels
SAEC,
significantly
greater
effect
relative
emissions.
Additionally,
pro-inflammatory
cytokines
including
IL-1β,
MMP-9,
RANTES
increased
due
exposure.
While
IL-6
IL-8
stimulated
scenarios,
VEGF
exclusively
exposures.
Notably,
induced
metabolic
perturbation
amino
acids
metabolism,
as
well
redox-regulated
pathways
arginine,
methionine,
cysteine,
vitamin
B3
whereas
caused
fatty
carnitine
dysregulation.
Taken
together,
these
advance
our
mechanistic
understanding
3D-printer-emissions-induced
toxicity
highlight
role
properties
play
mediating
outcomes.
Autoimmunity Reviews,
Год журнала:
2024,
Номер
23(6), С. 103583 - 103583
Опубликована: Июнь 1, 2024
T
cells
are
key
drivers
of
the
pathogenesis
autoimmune
diseases
by
producing
cytokines,
stimulating
generation
autoantibodies,
and
mediating
tissue
cell
damage.
Distinct
mitochondrial
metabolic
pathways
govern
direction
T-cell
differentiation
function
rely
on
specific
nutrients
enzymes.
Metabolic
substrate
uptake
metabolism
form
foundational
elements
for
activation,
proliferation,
differentiation,
effector
function,
contributing
to
dynamic
interplay
between
immunological
signals
in
coordinating
adaptive
immunity.
Perturbations
availability
enzyme
activity
may
impair
immunosuppressive
fostering
autoreactive
responses
disrupting
immune
homeostasis,
ultimately
disease
pathogenesis.
A
growing
body
studies
has
explored
how
processes
regulate
diverse
subsets
such
as
systemic
lupus
erythematosus
(SLE),
multiple
sclerosis
(MS),
hepatitis
(AIH),
inflammatory
bowel
(IBD),
psoriasis.
This
review
describes
coordination
biology
metabolism,
including
electron
transport
chain
(ETC),
oxidative
phosphorylation,
amino
acid
fatty
one‑carbon
metabolism.
study
elucidated
intricate
crosstalk
programs,
signal
transduction
pathways,
transcription
factors.
summarizes
potential
therapeutic
targets
signaling
diseases,
providing
insights
future
studies.
Journal of Cell Science,
Год журнала:
2025,
Номер
138(9)
Опубликована: Май 1, 2025
As
we
have
learned
more
about
mitochondria
over
the
past
decades,
including
their
essential
cellular
roles
and
how
altered
mitochondrial
biology
results
in
disease,
it
has
become
apparent
that
they
are
not
just
powerplants
pumping
out
ATP
at
whim
of
cell.
Rather,
dynamic
information
energy
processors
play
crucial
directing
dozens
processes
behaviors.
They
provide
instructions
to
enact
programs
regulate
various
operations,
such
as
complex
metabolic
networks,
signaling
innate
immunity,
even
control
cell
fate,
dictating
when
cells
should
divide,
differentiate
or
die.
To
help
current
future
generations
biologists
incorporate
dynamic,
multifaceted
nature
assimilate
modern
discoveries
into
scientific
framework,
need
a
21st
century
'rebranding'.
In
this
Opinion
article,
argue
be
considered
'Chief
Executive
Organelle'
-
CEO
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Окт. 6, 2023
Abstract
Pancreatic
ductal
adenocarcinoma
(PDAC)
cells
have
a
great
demand
for
nutrients
in
the
form
of
sugars,
amino
acids,
and
lipids.
Particularly,
acids
are
critical
cancer
growth
and,
as
intermediates,
connect
glucose,
lipid
nucleotide
metabolism.
PDAC
meet
these
requirements
by
upregulating
selective
acid
transporters.
Here
we
show
that
SLC38A5
(SN2/SNAT5),
neutral
transporter
is
highly
upregulated
functional
cells.
Using
CRISPR/Cas9-mediated
knockout
SLC38A5,
its
tumor
promoting
role
an
vitro
cell
line
model
well
subcutaneous
xenograft
mouse
model.
metabolomics
RNA
sequencing,
significant
reduction
many
substrates
OXPHOS
inactivation
response
to
deletion.
Experimental
validation
demonstrates
inhibition
mTORC1,
glycolysis
mitochondrial
respiration
KO
cells,
suggesting
serious
metabolic
crisis
associated
with
Since
activators
mTORC1
TCA
cycle
intermediates/precursors,
speculate
insufficiency
possible
link
between
deletion
respiration,
underlying
mechanism
attenuation.
Overall,
promotes
PDAC,
thereby
identifying
novel,
hitherto
unknown,
therapeutic
target
PDAC.
The Crop Journal,
Год журнала:
2024,
Номер
12(4), С. 1185 - 1195
Опубликована: Июль 14, 2024
Low
temperatures
during
germination
inhibit
seed
growth,
lead
to
small
and
weak
seedlings,
significantly
reduce
the
wheat
yield.
Alleviating
adverse
effects
of
low
temperature
on
is
highly
important
for
achieving
high
stable
yields.
In
this
study,
Tongmai
6
(insensitive)
Zhengmai
113
(sensitive),
which
have
different
low-temperature
sensitivities
were
treated
with
germination.
The
transcriptome,
metabolome
physiological
data
revealed
that
decreased
rate,
downregulated
expression
a
large
number
genes
involved
in
regulating
glycometabolism,
inhibited
carbon,
nitrogen
(especially
amino
acids)
energy
metabolism
seeds.
Arginine
content
increased
at
temperature,
its
increase
low-temperature-tolerant
variety
was
greater
than
sensitive
variety.
priming
experiment
showed
treatment
an
appropriate
concentration
arginine
improved
rate.
conversion
starch
soluble
sugar
under
exogenous
conditions,
key
metabolites
increased,
utilization
ATP
seeds
increased.
Taken
together,
by
relieving
inhibition
carbon
improving
metabolism.