Associations of indoor airborne microbiome with systemic inflammation in the context of indoor particulate matter pollution and the metabolic mechanisms

Journal of Environmental Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution

Biomedicines, Год журнала: 2025, Номер 13(4), С. 963 - 963

Опубликована: Апрель 15, 2025

Background/Objectives: This review has been prepared to promote interest in the interdisciplinary study of mitochondrial dysfunction (MD) and atherosclerosis. aims describe state this problem indicate direction for further implementation knowledge clinical medicine. Methods: Extensive research literature was implemented elucidate role molecular mechanisms MD pathogenesis Results: A view on atherosclerosis through prism about is presented. cause primary mechanism onset progression It proposed that be considered context a continuum. Conclusions: are united by common pathogenesis. Knowledge should used argue healthy lifestyle as way prevent The development new approaches diagnosing treating an urgent task challenge modern science.

Язык: Английский

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Bird’s Eye View on Mycobacterium tuberculosis–HIV Coinfection: Understanding the Molecular Synergism, Challenges, and New Approaches to Therapeutics

ACS Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is the most common secondary infection in Human Immunodeficiency Virus (HIV) infected population, accounting for more than one-fourth of deaths people living with HIV (PLWH). Reciprocally, increases susceptibility to primary TB or reactivation latent several folds. The synergistic interactions between M.tb and not only potentiate their deleterious impact but also complicate clinical management both diseases. M.tb-HIV coinfected patients have a high risk failure accurate diagnosis, treatment inefficiency HIV, concurrent nontuberculous mycobacterial infections, other comorbidities such as diabetes mellitus, severe cytotoxicity due drug overburden, immune reconstitution inflammatory syndrome (IRIS). need hour understand coinfection biology collective on host immunocompetence think out-of-the-box perspectives, including host-directed therapy under rising view homeostatic medicines. This review aims highlight molecular players, from pathogens host, that facilitate host-associated proteins/enzymes regulating immunometabolism, underlining potential targets designing screening chemical inhibitors reduce burden concomitantly during coinfection. To appreciate necessity revisiting therapeutic approaches research priorities, we provide glimpse anti-TB antiretroviral drug-drug interactions, project gaps our understanding biology, enlist some key initiatives will help us deal epidemic

Язык: Английский

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Naphthenic Acid Fraction Components-Induced Metabolic and Mitochondrial Alterations in Rat Hepatoma Cells: Monitoring Metabolic Reprogramming with Tryptophan–Kynurenine Ratio

Journal of Xenobiotics, Год журнала: 2025, Номер 15(3), С. 61 - 61

Опубликована: Апрель 24, 2025

Altered body condition and diminished growth in wildlife the Alberta Oil Sands Region (AOSR) are prompting investigations into impact of oil sands industrial activity on region. Chemical constituents from bitumen-influenced waters, including process-affected water (OSPW), can disrupt endocrine signaling, leading to aberrant lipid accumulation altered glycemic control mammals. This study aimed investigate effects naphthenic acid fraction components (NAFCs), derived OSPW, energy homeostasis using McA-RH7777 rat hepatocyte model. Cells were exposed NAFCs at nominal concentrations 0, 0.73, 14.7, 73.4 mg/L for 24 48 h. We assessed gene expression related glucose metabolism measured triglyceride accumulation, glucose, fatty uptake. NAFC exposure (14.7 mg/L) reduced levels uptake increased beta-oxidation genes, suggesting a metabolic switch oxidation. substrate availability signifies shift cellular dynamics, potentially linked mitochondrial function. To this, we conducted adenosine triphosphate (ATP), membrane potential, terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assays measure ATP levels, apoptosis, respectively. At both time points, resulted induced hyperpolarization, apoptosis. These results suggest that efficiency is compromised, necessitating adaptations maintain homeostasis. Given cells exhibit flexibility allows them dynamically respond changes availability, further demonstrated kynurenine-tryptophan ratio (KTR) serves as marker under these stress conditions. work provides mechanistic framework understanding how bitumen-derived organic contaminants may function living AOSR. findings support use molecular markers like KTR evaluate sub-lethal environmental health monitoring.

Язык: Английский

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Alterations in hepatic amino acid metabolism related to MASLD in individuals with obesity

Journal of Physiology and Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Язык: Английский

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