Bird’s Eye View on Mycobacterium tuberculosis–HIV Coinfection: Understanding the Molecular Synergism, Challenges, and New Approaches to Therapeutics DOI

Siranjeevi Rangaraj,

Anushka Agarwal,

Sharmistha Banerjee

и другие.

ACS Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is the most common secondary infection in Human Immunodeficiency Virus (HIV) infected population, accounting for more than one-fourth of deaths people living with HIV (PLWH). Reciprocally, increases susceptibility to primary TB or reactivation latent several folds. The synergistic interactions between M.tb and not only potentiate their deleterious impact but also complicate clinical management both diseases. M.tb-HIV coinfected patients have a high risk failure accurate diagnosis, treatment inefficiency HIV, concurrent nontuberculous mycobacterial infections, other comorbidities such as diabetes mellitus, severe cytotoxicity due drug overburden, immune reconstitution inflammatory syndrome (IRIS). need hour understand coinfection biology collective on host immunocompetence think out-of-the-box perspectives, including host-directed therapy under rising view homeostatic medicines. This review aims highlight molecular players, from pathogens host, that facilitate host-associated proteins/enzymes regulating immunometabolism, underlining potential targets designing screening chemical inhibitors reduce burden concomitantly during coinfection. To appreciate necessity revisiting therapeutic approaches research priorities, we provide glimpse anti-TB antiretroviral drug-drug interactions, project gaps our understanding biology, enlist some key initiatives will help us deal epidemic

Язык: Английский

Ubiquitination regulation of mitochondrial homeostasis: a new sight for the treatment of gastrointestinal tumors DOI Creative Commons

Bingqian Huang,

Yang Yulin,

Jinming Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 11, 2025

Mitochondrial homeostasis (MH) refers to the dynamic balance of mitochondrial number, function, and quality within cells. Maintaining MH is significant in occurrence, development, clinical treatment Gastrointestinal (GI) tumors. Ubiquitination, as an important post-translational modification mechanism proteins, plays a central role regulation MH. Over past decade, research on by ubiquitination has focused biogenesis, dynamics, Mitophagy, metabolism during these processes. This review summarizes potential therapeutic targets ubiquitin (Ub)-regulated intervention GI

Язык: Английский

Процитировано

0

Elucidating the co-metabolism mechanism of 4-chlorophenol and 4-chloroaniline degradation by Rhodococcus through genomics and transcriptomics DOI

Yonglin Bo,

Yanqing Niu,

Mingjun Zhu

и другие.

Environmental Research, Год журнала: 2025, Номер 274, С. 121362 - 121362

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

0

Associations of indoor airborne microbiome with systemic inflammation in the context of indoor particulate matter pollution and the metabolic mechanisms DOI
Yetong Zhao, Luyi Li,

Wenlou Zhang

и другие.

Journal of Environmental Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution DOI Creative Commons
Ганна Володимирівна Невойт, Gediminas Jaruševičius, М. M. Potyazhenko

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 963 - 963

Опубликована: Апрель 15, 2025

Background/Objectives: This review has been prepared to promote interest in the interdisciplinary study of mitochondrial dysfunction (MD) and atherosclerosis. aims describe state this problem indicate direction for further implementation knowledge clinical medicine. Methods: Extensive research literature was implemented elucidate role molecular mechanisms MD pathogenesis Results: A view on atherosclerosis through prism about is presented. cause primary mechanism onset progression It proposed that be considered context a continuum. Conclusions: are united by common pathogenesis. Knowledge should used argue healthy lifestyle as way prevent The development new approaches diagnosing treating an urgent task challenge modern science.

Язык: Английский

Процитировано

0

Bird’s Eye View on Mycobacterium tuberculosis–HIV Coinfection: Understanding the Molecular Synergism, Challenges, and New Approaches to Therapeutics DOI

Siranjeevi Rangaraj,

Anushka Agarwal,

Sharmistha Banerjee

и другие.

ACS Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is the most common secondary infection in Human Immunodeficiency Virus (HIV) infected population, accounting for more than one-fourth of deaths people living with HIV (PLWH). Reciprocally, increases susceptibility to primary TB or reactivation latent several folds. The synergistic interactions between M.tb and not only potentiate their deleterious impact but also complicate clinical management both diseases. M.tb-HIV coinfected patients have a high risk failure accurate diagnosis, treatment inefficiency HIV, concurrent nontuberculous mycobacterial infections, other comorbidities such as diabetes mellitus, severe cytotoxicity due drug overburden, immune reconstitution inflammatory syndrome (IRIS). need hour understand coinfection biology collective on host immunocompetence think out-of-the-box perspectives, including host-directed therapy under rising view homeostatic medicines. This review aims highlight molecular players, from pathogens host, that facilitate host-associated proteins/enzymes regulating immunometabolism, underlining potential targets designing screening chemical inhibitors reduce burden concomitantly during coinfection. To appreciate necessity revisiting therapeutic approaches research priorities, we provide glimpse anti-TB antiretroviral drug-drug interactions, project gaps our understanding biology, enlist some key initiatives will help us deal epidemic

Язык: Английский

Процитировано

0