ACS Infectious Diseases,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis
(M.tb),
is
the
most
common
secondary
infection
in
Human
Immunodeficiency
Virus
(HIV)
infected
population,
accounting
for
more
than
one-fourth
of
deaths
people
living
with
HIV
(PLWH).
Reciprocally,
increases
susceptibility
to
primary
TB
or
reactivation
latent
several
folds.
The
synergistic
interactions
between
M.tb
and
not
only
potentiate
their
deleterious
impact
but
also
complicate
clinical
management
both
diseases.
M.tb-HIV
coinfected
patients
have
a
high
risk
failure
accurate
diagnosis,
treatment
inefficiency
HIV,
concurrent
nontuberculous
mycobacterial
infections,
other
comorbidities
such
as
diabetes
mellitus,
severe
cytotoxicity
due
drug
overburden,
immune
reconstitution
inflammatory
syndrome
(IRIS).
need
hour
understand
coinfection
biology
collective
on
host
immunocompetence
think
out-of-the-box
perspectives,
including
host-directed
therapy
under
rising
view
homeostatic
medicines.
This
review
aims
highlight
molecular
players,
from
pathogens
host,
that
facilitate
host-associated
proteins/enzymes
regulating
immunometabolism,
underlining
potential
targets
designing
screening
chemical
inhibitors
reduce
burden
concomitantly
during
coinfection.
To
appreciate
necessity
revisiting
therapeutic
approaches
research
priorities,
we
provide
glimpse
anti-TB
antiretroviral
drug-drug
interactions,
project
gaps
our
understanding
biology,
enlist
some
key
initiatives
will
help
us
deal
epidemic
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 11, 2025
Mitochondrial
homeostasis
(MH)
refers
to
the
dynamic
balance
of
mitochondrial
number,
function,
and
quality
within
cells.
Maintaining
MH
is
significant
in
occurrence,
development,
clinical
treatment
Gastrointestinal
(GI)
tumors.
Ubiquitination,
as
an
important
post-translational
modification
mechanism
proteins,
plays
a
central
role
regulation
MH.
Over
past
decade,
research
on
by
ubiquitination
has
focused
biogenesis,
dynamics,
Mitophagy,
metabolism
during
these
processes.
This
review
summarizes
potential
therapeutic
targets
ubiquitin
(Ub)-regulated
intervention
GI
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 963 - 963
Опубликована: Апрель 15, 2025
Background/Objectives:
This
review
has
been
prepared
to
promote
interest
in
the
interdisciplinary
study
of
mitochondrial
dysfunction
(MD)
and
atherosclerosis.
aims
describe
state
this
problem
indicate
direction
for
further
implementation
knowledge
clinical
medicine.
Methods:
Extensive
research
literature
was
implemented
elucidate
role
molecular
mechanisms
MD
pathogenesis
Results:
A
view
on
atherosclerosis
through
prism
about
is
presented.
cause
primary
mechanism
onset
progression
It
proposed
that
be
considered
context
a
continuum.
Conclusions:
are
united
by
common
pathogenesis.
Knowledge
should
used
argue
healthy
lifestyle
as
way
prevent
The
development
new
approaches
diagnosing
treating
an
urgent
task
challenge
modern
science.
ACS Infectious Diseases,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis
(M.tb),
is
the
most
common
secondary
infection
in
Human
Immunodeficiency
Virus
(HIV)
infected
population,
accounting
for
more
than
one-fourth
of
deaths
people
living
with
HIV
(PLWH).
Reciprocally,
increases
susceptibility
to
primary
TB
or
reactivation
latent
several
folds.
The
synergistic
interactions
between
M.tb
and
not
only
potentiate
their
deleterious
impact
but
also
complicate
clinical
management
both
diseases.
M.tb-HIV
coinfected
patients
have
a
high
risk
failure
accurate
diagnosis,
treatment
inefficiency
HIV,
concurrent
nontuberculous
mycobacterial
infections,
other
comorbidities
such
as
diabetes
mellitus,
severe
cytotoxicity
due
drug
overburden,
immune
reconstitution
inflammatory
syndrome
(IRIS).
need
hour
understand
coinfection
biology
collective
on
host
immunocompetence
think
out-of-the-box
perspectives,
including
host-directed
therapy
under
rising
view
homeostatic
medicines.
This
review
aims
highlight
molecular
players,
from
pathogens
host,
that
facilitate
host-associated
proteins/enzymes
regulating
immunometabolism,
underlining
potential
targets
designing
screening
chemical
inhibitors
reduce
burden
concomitantly
during
coinfection.
To
appreciate
necessity
revisiting
therapeutic
approaches
research
priorities,
we
provide
glimpse
anti-TB
antiretroviral
drug-drug
interactions,
project
gaps
our
understanding
biology,
enlist
some
key
initiatives
will
help
us
deal
epidemic
