Journal of Zhejiang University (Medical Sciences),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
To
investigate
the
effect
of
Shenge
powder
(SGP)
on
myocardial
fibrosis
in
rats
with
heart
failure
after
infarction
and
its
relation
lysyl
oxidase
like
protein
2
(LOXL2)/transforming
growth
factor-β1
(TGF-β1)/IL-11
signaling
pathway.
Seventy-two
SPF
male
SD
were
divided
into
blank
control
group,
model
SGP
small
dose
large
positive
dose+LOXL2
activator
12
each
group.
Except
for
post-myocardial
was
induced
by
coronary
constriction
all
groups.
Corresponding
treatments
given
immediately
successful
modeling,
once
a
day
4
weeks.
Left
ventricular
fractional
shortening
(LVFS)
left
ejection
fraction
(LVEF)
detected
Color
Doppler
ultrasound
imaging.
Levels
IL-1β
IL-6
serum
analyzed
ELISA
method,
Myocardial
collagen
volume
(CVF)
evaluated
Masson
staining.
Expressions
Ⅰ
α-smooth
muscle
actin
(α-SMA)
tissue
immunohistochemical
The
mRNA
expressions
matrix
metalloproteinase-9
(MMP-9)
inhibitor
metalloproteinase
1
(TIMP-1)
qRT-PCR.
Expression
LOXL2,
TGF-β1,
IL-11
proteins
Western
blotting.
Compared
LVFS
LVEF
group
decreased,
levels
elevated,
CVF
value,
α-SMA
tissue,
MMP-9
TIMP-1
mRNA,
increased
(all
P<0.05).
increased,
Collagen
decreased
(P<0.05);
while
LOXL2
reversed
improvement
high-dose
infarction.
may
inhibit
inhibiting
LOXL2/TGF-β1/IL-11
Pharmacological Research,
Год журнала:
2024,
Номер
206, С. 107281 - 107281
Опубликована: Июнь 26, 2024
Cardiovascular
diseases
(CVDs)
have
a
complex
pathogenesis
and
pose
major
threat
to
human
health.
Cardiomyocytes
low
regenerative
capacity,
their
death
is
key
factor
in
the
morbidity
mortality
of
many
CVDs.
Cardiomyocyte
can
be
regulated
by
specific
signaling
pathways
known
as
programmed
cell
(PCD),
including
apoptosis,
necroptosis,
autophagy,
pyroptosis,
ferroptosis,
etc.
Abnormalities
PCD
lead
development
variety
cardiovascular
diseases,
there
are
also
molecular-level
interconnections
between
different
under
same
disease
model.
Currently,
link
cardiomyocytes
not
fully
understood.
This
review
describes
molecular
mechanisms
impact
cardiomyocyte
on
development.
Emphasis
placed
summary
drugs
potential
therapeutic
approaches
that
used
treat
targeting
blocking
cardiomyocytes.
Redox Biology,
Год журнала:
2024,
Номер
76, С. 103321 - 103321
Опубликована: Авг. 19, 2024
Cell
death
constitutes
a
critical
component
of
the
pathophysiology
cardiovascular
diseases.
A
growing
array
non-apoptotic
forms
regulated
cell
(RCD)-such
as
necroptosis,
ferroptosis,
pyroptosis,
and
cuproptosis-has
been
identified
is
intimately
linked
to
various
conditions.
These
RCD
are
governed
by
genetically
programmed
mechanisms
within
cell,
with
epigenetic
modifications
being
common
crucial
regulatory
method.
Such
include
DNA
methylation,
RNA
histone
acetylation,
non-coding
RNAs.
This
review
recaps
roles
modifications,
RNAs
in
diseases,
well
which
regulate
key
proteins
involved
death.
Furthermore,
we
systematically
catalog
existing
pharmacological
agents
targeting
novel
their
action
article
aims
underscore
pivotal
role
precisely
regulating
specific
pathways
thus
offering
potential
new
therapeutic
avenues
that
may
prove
more
effective
safer
than
traditional
treatments.
Phytomedicine,
Год журнала:
2024,
Номер
132, С. 155632 - 155632
Опубликована: Май 22, 2024
Type
2
cardiorenal
syndrome
(CRS)
is
a
progressive
renal
insufficiency
in
patients
with
chronic
heart
failure,
but
its
pathophysiology
still
unclear.
The
Chinese
medicine
Zhenwu
Decoction
plays
an
important
role
the
prevention
and
treatment
of
2-CRS,
however,
mechanism
action
remains
unknown.
Journal of Cancer,
Год журнала:
2023,
Номер
15(2), С. 494 - 507
Опубликована: Дек. 5, 2023
Pyroptosis,
a
highly
regulated
form
of
cell
death,
could
hold
the
key
to
revolutionizing
cancer
treatment.
With
posing
significant
global
health
challenge
due
its
high
morbidity
and
mortality
rates,
exploring
unconventional
therapeutic
approaches
becomes
imperative.
Chinese
medicine,
renowned
for
holistic
principles,
presents
intriguing
possibilities
treating
gastric
(GC).
Notably,
baicalin,
prominent
component
found
in
traditional
herb
Scutellaria
baicalensis
Georgi,
has
shown
promising
clinical
potential
treatment.To
shed
light
on
this
phenomenon,
multidisciplinary
approach
was
undertaken,
combining
systems
biology,
bioinformatics,
