Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102631 - 102631
Опубликована: Дек. 1, 2024
Язык: Английский
Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102631 - 102631
Опубликована: Дек. 1, 2024
Язык: Английский
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(6), С. 167247 - 167247
Опубликована: Май 16, 2024
Язык: Английский
Процитировано
10Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июль 4, 2024
Lactylation is a process where lactate, cellular metabolism byproduct, added to proteins, altering their functions. In the realm of macrophage activation, lactylation impacts inflammatory response and immune regulation. Understanding effects on activation vital in lung diseases, as abnormal function are pivotal conditions like pneumonia, pulmonary fibrosis, COPD, cancer. This review explores concept lactylation, its regulation recent research progress diseases. It offers new insights into disease pathogenesis potential therapeutic targets.
Язык: Английский
Процитировано
10MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Март 1, 2025
Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic epigenetic mechanisms collectively contribute to the disruption pulmonary homeostasis. In recent years, advancements research technology have identified numerous gene deletions mutations, addition bone morphogenetic protein receptor type 2, that are closely associated with remodeling process PH. Additionally, modifications such RNA methylation, DNA histone modification, noncoding RNAs been shown precisely regulate PH molecular networks cell-type-specific manner, emerging potential biomarkers therapeutic targets. This review summarizes analyzes roles currently genes factors PH, emphasizing pivotal role long ncRNAs its regulation. it examines current clinical preclinical therapies for targeting these explores new treatment strategies.
Язык: Английский
Процитировано
2Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 5, 2024
High levels of lactate are positively associated with prognosis and mortality in pulmonary hypertension (PH). Lactate dehydrogenase A (LDHA) is a key enzyme for the production lactate. This study undertaken to investigate role molecular mechanisms LDHA PH.
Язык: Английский
Процитировано
5BMC Immunology, Год журнала: 2025, Номер 26(1)
Опубликована: Фев. 10, 2025
Pulmonary arterial hypertension (PAH) is a critical cardiopulmonary vascular disorder marked by the progressive elevation of pulmonary artery pressure, increased resistance, and eventual right heart failure. Research has shown that various immune cells play significant role in pathogenesis PAH, both patients diagnosed with condition experimental models PAH. Cell–cell communication important for PAH progression therapies, while global cell landscape intercellular signaling not been elucidated. We performed single-cell RNA sequencing on NCBI Gene Expression Omnibus (GEO) databases GSE169471, GSE 210248, GSE228643 GSE244781, analyzed lung tissue samples across healthy controls patients. In total, approximately 124,561 were total 34 clusters identified. integrated results multiple used an enhanced workflow to overcome limitations single study. this study, we elucidated functional characteristics potential regulatory interactions several subpopulations have previously documented similar research. constructed comprehensive communications at resolution, which expected significantly advance development personalized diagnostic therapeutic strategies demonstrated transcriptomic features different types presented in-depth analysis T subsets, myeloid heterogeneity SMCs FBs subsets dynamics exhibited suggests targeting cytotoxic regulation may be strategy. Significant changes functions especially focused GPNMB+ macrophages. addition, CellChat NicheNet analyses reveal altered dys-regulated pathways progression. The MIF IL-1 induced inflammatory response greatly driven. systematically explored population target valuable developing new precise therapies.
Язык: Английский
Процитировано
0Respiratory Research, Год журнала: 2025, Номер 26(1)
Опубликована: Март 12, 2025
Pulmonary arterial hypertension (PAH) is a complex and progressive disease characterized by elevated pulmonary artery pressure vascular remodeling. Recent studies have underscored the pivotal role of metabolic dysregulation epigenetic modifications in pathogenesis PAH. Lactate, byproduct glycolysis, now recognized as key molecule that links cellular metabolism with activity regulation. findings indicate that, addition to altered glycolytic dysregulated. Lactate homeostasis lactylation—a novel modification—also play significant development This review synthesizes current knowledge regarding relationship between PAH, particular focus on cumulative effects lactate cells. Furthermore, lactylation, an emerging modification, discussed context By elucidating interplay lactylation this aims provide insights into potential therapeutic targets. Understanding these pathways may lead innovative strategies for managing PAH improving patient outcomes. Future research should underlying mechanisms through which influences pathophysiology thereby aiding targeted interventions.
Язык: Английский
Процитировано
0Metabolism, Год журнала: 2025, Номер unknown, С. 156234 - 156234
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Mediators of Inflammation, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Objective: Hypoxia-glycolysis-lactylation (HGL) may play a crucial role in neonatal sepsis (NS). This study aims to identify HGL marker genes NS and explore immune microenvironment among subtypes. Materials Methods: The gene expression dataset GSE69686, comprising 64 cases 85 controls, was selected for analysis. Based on the screened HGL-related genes, diagnostic prediction models were constructed using nine machine learning algorithms, molecular subtypes of identified through consensus clustering. Subsequently, heterogeneity biological functions cell infiltration different analyzed. Finally, lactylation validated GSE25504 dataset, clinical samples, mouse neutrophil, respectively. Results: MERTK, HK3, PGK1, STAT3 as model support vector (SVM) algorithm exhibited optimal predictive performance. patterns, two distinct identified. Functional enrichment analysis highlighted significant immune-related pathways, while revealed differences neutrophil proportions between Furthermore, levels positively correlated with infiltration. Importantly, experimental validation results consistent findings from bioinformatics Conclusion: their associated genes. These will contribute elucidating disease's establishing appropriate personalized therapeutic approaches.
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116787 - 116787
Опубликована: Май 23, 2024
Pulmonary hypertension (PH) is a cardiovascular disorder characterized by substantial morbidity and mortality rates. It chronic condition intricate pathogenesis uncontrollable factors. We summarized the pathological effects of estrogen, genetics, neuroinflammation, intestinal microbiota, metabolic reorganization, histone modification on PH. PH not only pulmonary vascular disease, but also systemic disease. The findings emphasize that onset exclusively confined to vasculature, consequently necessitating treatment approaches extend beyond targeting blood vessels. Hence, research mechanism limited target organs such as vessels, focuses exploring other fields (such modification).
Язык: Английский
Процитировано
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