Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential DOI Creative Commons

A. Cristina,

David Briand,

Aman Kukde

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

ABSTRACT Controlled proliferation of neural stem cells (NSCs) builds a functional nervous system during development. While their cellular niche is recognized as signalling hub, the contribution its structure and mechanics in regulating neurogenesis remains unexplored. The Drosophila larval central contains self-renewing NSCs close contact with cortex glial cells. Transcriptomics identified triad immunoglobulin superfamily cell adhesion molecules (Dpr10/Dpr6 glia DIP-α NSCs) which physically mechanically connect NSC membranes, acting mechanoregulators. Their disruption increases cortical tension, causing non-autonomous mitotic defects NSCs, characterized by abnormal spindle morphologies impaired progression. Additionally, elevated tensile forces increase Lamin content protective response also resulting nuclear deformation. Ultimately proliferative potential genome integrity are compromised. Our study reveals that native mechanical properties transmitted to regulate function. Graphical abstract

Язык: Английский

Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells DOI Creative Commons
Vishal Chavda, Dhananjay Yadav, Snehal S. Patel

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(3), С. 284 - 284

Опубликована: Март 15, 2024

Diabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage the heart, kidney, eyes, and nerves. Elevated brain function cognitive abilities. They also lead various neurological neuropsychiatric disorders, including neurodegeneration decline. High neuronal can cause drastic due neurotoxicity. Astrocytes, type glial cell, play vital role in maintaining through neuron–astrocyte coupling. Hyperglycemia progressive decline networks impairment, contributing dysfunction fostering neurodegenerative environment. In this review, we summarize connections, functions, impairments cells diabetic brain. We effects hyperglycemia on functions

Язык: Английский

Процитировано

9

Generating neurons in the embryonic and adult brain: compared principles and mechanisms DOI Creative Commons

Mathilde Chouly,

Laure Bally‐Cuif

Comptes Rendus Biologies, Год журнала: 2024, Номер 347(G1), С. 199 - 221

Опубликована: Ноя. 13, 2024

Neurogenesis is a lifelong process, generating neurons in the right amount, time and place with correct identity to permit growth, function, plasticity repair of nervous system, notably brain. originates from neural progenitor cells (NPs), endowed capacity divide, renew maintain population, or commit engage neurogenesis process. In adult brain, these progenitors are classically called stem (NSCs). We review here commonalities differences between NPs NSCs, their cellular molecular attributes but also potential, regulators lineage, embryonic brains. Our comparison based on two most studied model systems, namely telencephalon zebrafish mouse. discuss how population gives rise outstanding questions pertaining this transition. La neurogenèse est un processus continu qui génère des neurones en quantité, temps et lieu voulus avec l'identité correcte pour permettre la croissance, fonction, plasticité réparation du système nerveux, notamment cerveau. origine progéniteurs neuraux (PN), dotés de capacité se diviser, renouveler maintenir progénitrice, ou s'engager dans le neurogenèse. Dans cerveau adulte, ces sont classiquement appelés cellules souches neurales (CSN). Nous examinons ici les points communs différences entre PN CSN, leurs attributs cellulaires moléculaires, mais aussi leur potentiel, régulateurs lignage, cerveaux embryonnaires adultes. Notre comparaison basée sur deux systèmes modèles plus étudiés, à savoir télencéphale poisson-zèbre souris. discutons également façon dont donne naissance aux CSN adultes, restent suspens concernant cette

Процитировано

1

Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential DOI Creative Commons

A. Cristina,

David Briand,

Aman Kukde

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

ABSTRACT Controlled proliferation of neural stem cells (NSCs) builds a functional nervous system during development. While their cellular niche is recognized as signalling hub, the contribution its structure and mechanics in regulating neurogenesis remains unexplored. The Drosophila larval central contains self-renewing NSCs close contact with cortex glial cells. Transcriptomics identified triad immunoglobulin superfamily cell adhesion molecules (Dpr10/Dpr6 glia DIP-α NSCs) which physically mechanically connect NSC membranes, acting mechanoregulators. Their disruption increases cortical tension, causing non-autonomous mitotic defects NSCs, characterized by abnormal spindle morphologies impaired progression. Additionally, elevated tensile forces increase Lamin content protective response also resulting nuclear deformation. Ultimately proliferative potential genome integrity are compromised. Our study reveals that native mechanical properties transmitted to regulate function. Graphical abstract

Язык: Английский

Процитировано

0