Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells
Brain Sciences,
Год журнала:
2024,
Номер
14(3), С. 284 - 284
Опубликована: Март 15, 2024
Diabetes
is
a
chronic
metabolic
condition
associated
with
high
levels
of
blood
glucose
which
leads
to
serious
damage
the
heart,
kidney,
eyes,
and
nerves.
Elevated
brain
function
cognitive
abilities.
They
also
lead
various
neurological
neuropsychiatric
disorders,
including
neurodegeneration
decline.
High
neuronal
can
cause
drastic
due
neurotoxicity.
Astrocytes,
type
glial
cell,
play
vital
role
in
maintaining
through
neuron–astrocyte
coupling.
Hyperglycemia
progressive
decline
networks
impairment,
contributing
dysfunction
fostering
neurodegenerative
environment.
In
this
review,
we
summarize
connections,
functions,
impairments
cells
diabetic
brain.
We
effects
hyperglycemia
on
functions
Язык: Английский
Generating neurons in the embryonic and adult brain: compared principles and mechanisms
Comptes Rendus Biologies,
Год журнала:
2024,
Номер
347(G1), С. 199 - 221
Опубликована: Ноя. 13, 2024
Neurogenesis
is
a
lifelong
process,
generating
neurons
in
the
right
amount,
time
and
place
with
correct
identity
to
permit
growth,
function,
plasticity
repair
of
nervous
system,
notably
brain.
originates
from
neural
progenitor
cells
(NPs),
endowed
capacity
divide,
renew
maintain
population,
or
commit
engage
neurogenesis
process.
In
adult
brain,
these
progenitors
are
classically
called
stem
(NSCs).
We
review
here
commonalities
differences
between
NPs
NSCs,
their
cellular
molecular
attributes
but
also
potential,
regulators
lineage,
embryonic
brains.
Our
comparison
based
on
two
most
studied
model
systems,
namely
telencephalon
zebrafish
mouse.
discuss
how
population
gives
rise
outstanding
questions
pertaining
this
transition.
La
neurogenèse
est
un
processus
continu
qui
génère
des
neurones
en
quantité,
temps
et
lieu
voulus
avec
l'identité
correcte
pour
permettre
la
croissance,
fonction,
plasticité
réparation
du
système
nerveux,
notamment
cerveau.
origine
progéniteurs
neuraux
(PN),
dotés
de
capacité
se
diviser,
renouveler
maintenir
progénitrice,
ou
s'engager
dans
le
neurogenèse.
Dans
cerveau
adulte,
ces
sont
classiquement
appelés
cellules
souches
neurales
(CSN).
Nous
examinons
ici
les
points
communs
différences
entre
PN
CSN,
leurs
attributs
cellulaires
moléculaires,
mais
aussi
leur
potentiel,
régulateurs
lignage,
cerveaux
embryonnaires
adultes.
Notre
comparaison
basée
sur
deux
systèmes
modèles
plus
étudiés,
à
savoir
télencéphale
poisson-zèbre
souris.
discutons
également
façon
dont
donne
naissance
aux
CSN
adultes,
restent
suspens
concernant
cette
Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
ABSTRACT
Controlled
proliferation
of
neural
stem
cells
(NSCs)
builds
a
functional
nervous
system
during
development.
While
their
cellular
niche
is
recognized
as
signalling
hub,
the
contribution
its
structure
and
mechanics
in
regulating
neurogenesis
remains
unexplored.
The
Drosophila
larval
central
contains
self-renewing
NSCs
close
contact
with
cortex
glial
cells.
Transcriptomics
identified
triad
immunoglobulin
superfamily
cell
adhesion
molecules
(Dpr10/Dpr6
glia
DIP-α
NSCs)
which
physically
mechanically
connect
NSC
membranes,
acting
mechanoregulators.
Their
disruption
increases
cortical
tension,
causing
non-autonomous
mitotic
defects
NSCs,
characterized
by
abnormal
spindle
morphologies
impaired
progression.
Additionally,
elevated
tensile
forces
increase
Lamin
content
protective
response
also
resulting
nuclear
deformation.
Ultimately
proliferative
potential
genome
integrity
are
compromised.
Our
study
reveals
that
native
mechanical
properties
transmitted
to
regulate
function.
Graphical
abstract
Язык: Английский