Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling

Molecules, Год журнала: 2024, Номер 29(8), С. 1729 - 1729

Опубликована: Апрель 11, 2024

Derived from hazelnuts, hazel leaf has been utilized in traditional folk medicine for centuries countries such as Portugal, Sweden, and Iran. In our previous investigations, we conducted a preliminary assessment of the polyphenol extract (referred to ZP) identified nine compounds, kaempferol chlorogenic acid, its composition. ZP shown promising properties an antioxidant anti-inflammatory agent. Our research revealed that protective effects against cisplatin-induced acute kidney injury (AKI). We comprehensive examination both pathological ultrastructural aspects found effectively ameliorated renal tissue lesions mitigated mitochondrial damage. Moreover, significantly suppressed malondialdehyde levels while increasing glutathione catalase concentrations kidneys AKI-induced mice. decreased number apoptotic cells pro-apoptotic protein expression mice human tubular epithelial (HK-2). Furthermore, treatment with increased proteins marking anti-ferroptosis, GPX4, FTH1, FSP1, experiments vivo vitro. elucidated underlying mechanisms ZP’s actions, revealing inhibitory effect on Yap phosphorylation regulation Lats expression, which exert influence kidneys. inhibiting Hippo pathway compromised nephroprotective vitro studies. summary, this shows exhibits renoprotective properties, reducing oxidative damage, apoptosis, ferroptosis by targeting pathway.

Язык: Английский

---

Regulation of the p53/SLC7A11/GPX4 Pathway by Gentamicin Induces Ferroptosis in HEI-OC1 Cells

Otology & Neurotology, Год журнала: 2024, Номер 45(8), С. 947 - 953

Опубликована: Июль 29, 2024

Gentamicin is a commonly used aminoglycoside antibiotic, with ototoxicity as significant side effect. Ferroptosis, an iron-dependent form of cell death, has been implicated in variety disorders. Whether ferroptosis impacts gentamicin not yet known. The current work in-vitro model to examine the influence gentamicin-induced on cochlear hair damage and probable molecular biological pathways.

Язык: Английский

---

Hazel leaf polyphenols ameliorate hyperuricemia-induced renal fibrosis through regulating uric acid metabolism and inhibiting ferroptosis via the Nrf2/GPX4 signaling axis

Journal of Functional Foods, Год журнала: 2024, Номер 123, С. 106579 - 106579

Опубликована: Ноя. 14, 2024

Язык: Английский

---

In-situ formation of deep eutectic supramolecule based extraction method coupled to valve switching ion chromatography mass spectrometry for the determination of aminoglycosides in meat

Journal of Chromatography A, Год журнала: 2025, Номер 1745, С. 465757 - 465757

Опубликована: Фев. 9, 2025

Язык: Английский

---

Rodent models in sensorineural hearing loss research: A comprehensive review

Life Sciences, Год журнала: 2024, Номер unknown, С. 123156 - 123156

Опубликована: Окт. 1, 2024

Язык: Английский

---

Advancements of ROS-based biomaterials for sensorineural hearing loss therapy

Biomaterials, Год журнала: 2024, Номер 316, С. 123026 - 123026

Опубликована: Дек. 15, 2024

Язык: Английский

---