Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages
Epigenomes,
Год журнала:
2024,
Номер
8(2), С. 22 - 22
Опубликована: Июнь 4, 2024
The
development
of
the
nervous
system
is
regulated
by
numerous
intracellular
molecules
and
cellular
signals
that
interact
temporally
spatially
with
extracellular
microenvironment.
three
major
cell
types
in
brain,
i.e.,
neurons
two
glial
cells
(astrocytes
oligodendrocytes),
are
generated
from
common
multipotent
neural
stem
(NSCs)
throughout
life.
However,
NSCs
do
not
have
this
multipotentiality
beginning.
During
cortical
development,
sequentially
obtain
abilities
to
differentiate
into
response
combinations
spatiotemporally
modulated
cell-intrinsic
epigenetic
alterations
extrinsic
factors.
After
completion
brain
a
limited
population
remains
adult
continues
produce
(adult
neurogenesis),
thus
contributing
learning
memory.
Many
biological
aspects
neurogenesis
changes
via
behavioral
control
NSCs.
Epigenetic
dysregulation
has
also
been
implicated
pathogenesis
various
diseases.
Here,
we
present
recent
advances
regulation
NSC
behavior
its
disorders.
Язык: Английский
The “Jekyll Side” of the S100B Protein: Its Trophic Action in the Diet
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 881 - 881
Опубликована: Фев. 28, 2025
The
calcium-binding
S100B
protein
is
concentrated
in
glial
cells
(including
enteroglial
cells)
the
nervous
system.
Its
conformation
and
amino
acid
composition
are
significantly
conserved
different
species;
this
characteristic
suggests
biological
role(s)
for
protein.
activity
concentration-dependent:
low
physiological
concentrations
exert
a
neurotrophic
effect,
while
high
proinflammatory/toxic
role.
role
of
currently
attracts
scientific
community's
primary
attention,
protein's
action
remains
unraveled-yet
remarkably
interesting.
This
now
topical
issue
due
to
recently
consolidated
notion
that
natural
trophic
nutrient
available
breast
milk
and/or
other
aliments,
possibly
interacting
with
body
districts
through
its
impact
on
microbiota.
These
recent
data
may
offer
novel
clues
understanding
challenging
Язык: Английский
Long Non-Coding RNAs in Stem Cell Regulation and Regenerative Medicine: Stemness, Differentiation, and Therapeutic Innovation
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
critical
regulators
in
stem
cell
biology,
influencing
cellular
functions
such
pluripotency,
differentiation,
and
self-renewal.
Their
unique
ability
to
modulate
gene
expression
at
multiple
levels—epigenetic,
transcriptional,
post-transcriptional—makes
lncRNAs
powerful
tools
for
controlling
fate.
In
regenerative
medicine,
understanding
the
roles
of
specific
can
enhance
therapeutic
approaches,
particularly
cell-based
tissue
repair
engineering.
By
modulating
lncRNA
activity,
researchers
potentially
direct
differentiation
toward
desired
lineages,
facilitating
development
functional
tissues
clinical
applications.
This
chapter
explores
how
influence
states,
highlights
current
research
therapies,
discusses
potential
future
applications
where
lncRNA-based
interventions
could
drive
advancements
engineering
medicine.
Язык: Английский
Neuronal expression of E2F4DN restores adult neurogenesis in homozygous 5xFAD mice via TrkB signaling
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
The
etiology
of
Alzheimer’s
disease
(AD)
has
been
associated
with
impaired
neurogenesis
in
the
adult
subventricular
zone
(SVZ),
but
molecular
mechanism
leading
to
this
impairment
remains
poorly
understood.
Neuronal
dysfunction
AD-affected
brain
might
lead
reduced
production
neuron-derived
paracrine
factors
acting
through
receptors
necessary
for
SVZ
(ASN).
To
test
hypothesis,
we
focused
on
TrkB
receptor,
which
can
transduce
signals
from
neurotrophins
BDNF
and
NT4/5,
since
is
known
regulate
ASN
process
its
function
becomes
altered
AD.
Here
show
that
homozygous
5xFAD
(h5xFAD)
mice.
This
prevented
by
administering
an
AAV.PHP.eB
vector
expresses
neurons
transcription
factor
E2F4
carrying
Thr249Ala/Th251Ala
mutation
(E2F4DN),
a
gene
therapeutic
approach
previously
demonstrated
exert
multifactorial
effects
mouse
model
use
culture
media
conditioned
primary
cortical
expressing
E2F4DN
was
able
recover
proliferative
differentiative
capacity
neural
stem
cells
(NSCs)
isolated
h5xFAD
effect
blocked
inhibiting
receptor.
Accordingly,
activation
mimicked
E2F4DN-conditioned
medium
NSCs,
finding
consistent
upregulation
NT4/5
expression
E2F4DN-transduced
neurons.
We
conclude
released
E2F4DN-expressing
phenotype
Therefore,
includes
recovery
signaling
NSCs.
Язык: Английский