ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Extracellular
vesicles
are
nanoscale
released
by
a
diversity
of
cells
that
mediate
intercellular
communication
transporting
an
array
biomolecules.
They
gaining
increasing
attention
in
cancer
research
due
to
their
ability
carry
specific
biomarkers.
This
characteristic
makes
them
potentially
useful
for
highly
sensitive,
noninvasive
diagnostic
procedures
and
more
precise
prognostic
assessments.
Consequently,
EVs
emerging
as
transformative
tool
treatment,
facilitating
early
detection
personalized
medicine.
Despite
significant
progress,
clinical
implementation
is
hindered
challenges
EV
isolation,
purification,
characterization.
However,
developing
advanced
biosensor
technologies
offers
promising
solutions
these
obstacles.
review
highlights
recent
progress
biosensors
analysis,
focusing
on
various
sensing
modalities
including
optical,
electrochemical,
microfluidic,
nanomechanical,
biological
sensors.
We
also
explore
techniques
characterization,
such
electron
microscopy,
atomic
force
nanoparticle
tracking
single-particle
analysis.
Furthermore,
the
critically
assesses
associated
with
put
forward
future
directions,
aiming
usher
cutting-edge
era
precision
medicine
through
advanced,
sensor-based,
diagnosis
detecting
EV-carried
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 30, 2024
Abstract
The
advancement
of
nanoscience
and
material
design
in
recent
times
has
facilitated
the
creation
point-of-care
devices
for
cancer
diagnosis
biomolecule
sensing.
Exosomes
(EXOs)
facilitate
transfer
bioactive
molecules
between
cells
diverse
local
distant
microenvironments,
thereby
contributing
to
progression
metastasis.
Specifically,
EXOs
derived
from
are
likely
function
as
biomarkers
early
detection
due
genetic
or
signaling
alterations
they
transport
payload
within
origin.
It
been
verified
that
circulate
steadily
bodily
secretions
contain
a
variety
information
indicates
tumor.
However,
acquiring
molecular
interactions
regarding
presented
significant
technical
challenges
their
nanoscale
nature
high
heterogeneity.
Colorimetry,
surface
plasmon
resonance
(SPR),
fluorescence,
Raman
scattering
examples
optical
techniques
utilized
quantify
exosomal
biomarkers,
including
lipids,
proteins,
RNA,
DNA.
Many
optically
active
nanoparticles
(NPs),
predominantly
carbon-based,
inorganic,
organic,
composite-based
nanomaterials,
have
employed
biosensing
technology.
exceptional
physical
properties
exhibited
by
carbon
NPs,
noble
metal
magnetic
progress
development
nanobiosensors
intended
originating
tumors.
Following
summary
biogenesis,
biological
functions,
biomarker
value
known
EXOs,
this
article
provides
an
update
on
methodologies
currently
under
investigation.
In
conclusion,
we
propose
some
potential
enhancements
biosensors
detecting
EXO,
utilizing
various
NP
materials
such
silicon
graphene
oxide
(GO),
quantum
dots
(QDs).
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 792 - 792
Опубликована: Июль 3, 2024
The
vast
regenerative
potential
of
stem
cells
has
laid
the
foundation
for
cell-based
therapies.
However,
certain
challenges
limit
application
therapeutic
use
cell-free
therapy
can
avoid
limitations
associated
with
Acellular
therapies
rely
on
biological
factors
released
by
cells,
including
growth
and
extracellular
vesicles
such
as
exosomes.
Due
to
their
comparable
potential,
acellular
may
provide
a
feasible
scalable
alternative
Exosomes
are
small
secreted
various
types
cells.
contain
parent
cell-derived
nucleic
acids,
proteins,
lipids,
other
bioactive
molecules.
They
play
an
important
role
in
intra-cellular
communication
influence
characteristics
inherit
properties
cells;
therefore,
exosomes
particular
interest
applications
medicine.
In
comparison
therapy,
exosome
offers
several
benefits,
easy
transport
storage,
no
risk
immunological
rejection,
few
ethical
dilemmas.
Unlike
be
lyophilized
stored
off-the-shelf,
making
standardized
more
accessible
while
reducing
overall
treatment
costs.
Exosome-based
treatments
therefore
readily
available
patients
at
time
care.
current
review
discusses
therapy.
explores
molecular
mechanism
biogenesis,
methods
isolation,
characterization.
addition,
latest
advancements
bioengineering
techniques
enhance
have
been
discussed.
well
diverse
diagnosis
diseases
reviewed
detail.
Frontiers in Oncology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 16, 2025
Multiple
Myeloma
(MM)
is
the
second
most
common
malignancy
of
hematopoietic
system,
accounting
for
approximately
10%
all
hematological
malignancies,
and
currently,
there
no
complete
cure.
Existing
research
indicates
that
exosomal
long
non-coding
RNAs
(lncRNAs)
play
a
crucial
regulatory
role
in
initiation
progression
tumors,
involving
various
interactions
such
as
lncRNA-miRNA,
lncRNA-mRNA,
lncRNA-RNA
binding
proteins
(RBP).
Despite
significant
clinical
application
potential
lncRNAs,
this
area
still
faces
challenges
due
to
their
low
abundance
technical
limitations.
To
our
knowledge,
review
first
comprehensively
integrate
elucidate
three
mechanisms
action
lncRNAs
MM,
propose
therapeutic
targets
cases
based
on
these
mechanisms.
We
highlight
latest
advancements
biomarkers
targets,
offering
not
only
comprehensive
analysis
MM
but
also
new
perspectives
methods
future
diagnosis
treatment
multiple
myeloma.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 144 - 144
Опубликована: Фев. 22, 2025
Exosome-like
nanovesicles
(ELNs)
derived
from
natural
products
are
gaining
attention
as
innovative
therapeutic
agents
due
to
their
biocompatibility,
low
immunogenicity,
and
capability
transport
bioactive
molecules
such
proteins,
lipids,
nucleic
acids.
These
plant-derived
ELNs
exhibit
structural
similarities
with
mammalian
exosomes,
making
them
suitable
for
drug
delivery,
microbiome-targeted
therapies,
regenerative
medicine.
Recent
studies
highlight
potential
in
treating
cancer,
inflammation,
metabolic
disorders.
Additionally,
have
applications
cosmetics,
agriculture,
the
food
industry.
This
review
combines
latest
advancements
research
on
ELNs,
focusing
isolation
techniques,
pharmacological
effects,
applications.
Although
offer
promising
opportunities,
several
challenges
must
be
addressed,
including
standardization,
large-scale
production,
vivo
efficacy.
By
summarizing
cutting-edge
suggesting
future
directions,
we
aim
inspire
further
development
of
next-generation
platforms.
Cancers,
Год журнала:
2025,
Номер
17(6), С. 940 - 940
Опубликована: Март 10, 2025
Exosomes
have
emerged
as
pivotal
players
in
precision
oncology,
offering
innovative
solutions
to
longstanding
challenges
such
metastasis,
therapeutic
resistance,
and
immune
evasion.
These
nanoscale
extracellular
vesicles
facilitate
intercellular
communication
by
transferring
bioactive
molecules
that
mirror
the
biological
state
of
their
parent
cells,
positioning
them
transformative
tools
for
cancer
diagnostics
therapeutics.
Recent
advancements
exosome
engineering,
artificial
intelligence
(AI)-driven
analytics,
isolation
technologies
are
breaking
barriers
scalability,
reproducibility,
clinical
application.
Bioengineered
exosomes
being
leveraged
CRISPR-Cas9
delivery,
while
AI
models
enhancing
biomarker
discovery
liquid
biopsy
accuracy.
Despite
these
advancements,
key
obstacles
heterogeneity
populations
lack
standardized
protocols
persist.
This
review
synthesizes
pioneering
research
on
biology,
molecular
translation,
emphasizing
dual
roles
both
mediators
tumor
progression
intervention.
It
also
explores
emerging
areas,
including
microbiome–exosome
interactions
integration
machine
learning
exosome-based
medicine.
By
bridging
innovation
with
translational
strategies,
this
work
charts
a
forward-looking
path
integrating
into
next-generation
care,
setting
it
apart
comprehensive
guide
overcoming
technological
hurdles
rapidly
evolving
field.
Cosmetics,
Год журнала:
2025,
Номер
12(1), С. 9 - 9
Опубликована: Янв. 13, 2025
This
study
addresses
a
significant
gap
in
the
clinical
validation
and
standardization
of
exosome-based
applications
within
domains
cosmetics
regenerative
medicine.
Despite
offering
thorough
overview
potential
therapeutic
benefits
underlying
mechanisms
exosomes,
manuscript
underscores
several
unresolved
challenges,
including
paucity
evidence,
regulatory
barriers,
inconsistencies
standardization,
incomplete
mechanistic
understanding.
The
primary
aim
this
research
is
to
conduct
systematic
comprehensive
review
existing
studies
on
exosomes
skincare.
To
achieve
this,
literature
was
performed,
drawing
major
medical
database
PubMed.
approach
facilitated
collection
meta-analysis
relevant
data,
ensuring
rigorous
assessment
recent
advancements
exosome
research.
main
outcomes
highlight
multifaceted
roles
promoting
skin
rejuvenation
mitigating
signs
aging.
Specific
discussed
include
pigmentation
correction,
wound
healing,
tissue
repair,
innovative
delivery
mechanisms.
Moreover,
examines
emerging
plastic
surgery
Challenges
limitations,
such
as
constraints,
hurdles,
need
for
further
validation,
are
critically
analyzed,
providing
framework
future
directions.
