Exosome-Based Sensor: A Landmark of the Precision Cancer Diagnostic Era DOI
Swarup Sonar, Asmit Das,

Lee Yeong Zher

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Extracellular vesicles are nanoscale released by a diversity of cells that mediate intercellular communication transporting an array biomolecules. They gaining increasing attention in cancer research due to their ability carry specific biomarkers. This characteristic makes them potentially useful for highly sensitive, noninvasive diagnostic procedures and more precise prognostic assessments. Consequently, EVs emerging as transformative tool treatment, facilitating early detection personalized medicine. Despite significant progress, clinical implementation is hindered challenges EV isolation, purification, characterization. However, developing advanced biosensor technologies offers promising solutions these obstacles. review highlights recent progress biosensors analysis, focusing on various sensing modalities including optical, electrochemical, microfluidic, nanomechanical, biological sensors. We also explore techniques characterization, such electron microscopy, atomic force nanoparticle tracking single-particle analysis. Furthermore, the critically assesses associated with put forward future directions, aiming usher cutting-edge era precision medicine through advanced, sensor-based, diagnosis detecting EV-carried

Язык: Английский

Emerging role of exosomes in cancer therapy: progress and challenges DOI Creative Commons
Jiale Li,

Jiachong Wang,

Zigui Chen

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Язык: Английский

Процитировано

25

Increasing the sensitivity and accuracy of detecting exosomes as biomarkers for cancer monitoring using optical nanobiosensors DOI Creative Commons
Saman Yasamineh,

Naghmeh Nikben,

Mareb Hamed Ahmed

и другие.

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Май 30, 2024

Abstract The advancement of nanoscience and material design in recent times has facilitated the creation point-of-care devices for cancer diagnosis biomolecule sensing. Exosomes (EXOs) facilitate transfer bioactive molecules between cells diverse local distant microenvironments, thereby contributing to progression metastasis. Specifically, EXOs derived from are likely function as biomarkers early detection due genetic or signaling alterations they transport payload within origin. It been verified that circulate steadily bodily secretions contain a variety information indicates tumor. However, acquiring molecular interactions regarding presented significant technical challenges their nanoscale nature high heterogeneity. Colorimetry, surface plasmon resonance (SPR), fluorescence, Raman scattering examples optical techniques utilized quantify exosomal biomarkers, including lipids, proteins, RNA, DNA. Many optically active nanoparticles (NPs), predominantly carbon-based, inorganic, organic, composite-based nanomaterials, have employed biosensing technology. exceptional physical properties exhibited by carbon NPs, noble metal magnetic progress development nanobiosensors intended originating tumors. Following summary biogenesis, biological functions, biomarker value known EXOs, this article provides an update on methodologies currently under investigation. In conclusion, we propose some potential enhancements biosensors detecting EXO, utilizing various NP materials such silicon graphene oxide (GO), quantum dots (QDs).

Язык: Английский

Процитировано

15

Stem Cell-Based Acellular Therapy: Insight into Biogenesis, Bioengineering and Therapeutic Applications of Exosomes DOI Creative Commons
Mahmood S. Choudhery, Taqdees Arif,

Ruhma Mahmood

и другие.

Biomolecules, Год журнала: 2024, Номер 14(7), С. 792 - 792

Опубликована: Июль 3, 2024

The vast regenerative potential of stem cells has laid the foundation for cell-based therapies. However, certain challenges limit application therapeutic use cell-free therapy can avoid limitations associated with Acellular therapies rely on biological factors released by cells, including growth and extracellular vesicles such as exosomes. Due to their comparable potential, acellular may provide a feasible scalable alternative Exosomes are small secreted various types cells. contain parent cell-derived nucleic acids, proteins, lipids, other bioactive molecules. They play an important role in intra-cellular communication influence characteristics inherit properties cells; therefore, exosomes particular interest applications medicine. In comparison therapy, exosome offers several benefits, easy transport storage, no risk immunological rejection, few ethical dilemmas. Unlike be lyophilized stored off-the-shelf, making standardized more accessible while reducing overall treatment costs. Exosome-based treatments therefore readily available patients at time care. current review discusses therapy. explores molecular mechanism biogenesis, methods isolation, characterization. addition, latest advancements bioengineering techniques enhance have been discussed. well diverse diagnosis diseases reviewed detail.

Язык: Английский

Процитировано

14

Exosomes as targeted diagnostic biomarkers: Recent studies and trends DOI

Aida Abbasi Marjani,

Nader D. Nader, Ayuob Aghanejad

и другие.

Life Sciences, Год журнала: 2024, Номер 354, С. 122985 - 122985

Опубликована: Авг. 14, 2024

Язык: Английский

Процитировано

12

Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma DOI Creative Commons
Hong Yan, Nan Jiang, M Kellis

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 14

Опубликована: Янв. 16, 2025

Multiple Myeloma (MM) is the second most common malignancy of hematopoietic system, accounting for approximately 10% all hematological malignancies, and currently, there no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in initiation progression tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, lncRNA-RNA binding proteins (RBP). Despite significant clinical application potential lncRNAs, this area still faces challenges due to their low abundance technical limitations. To our knowledge, review first comprehensively integrate elucidate three mechanisms action lncRNAs MM, propose therapeutic targets cases based on these mechanisms. We highlight latest advancements biomarkers targets, offering not only comprehensive analysis MM but also new perspectives methods future diagnosis treatment multiple myeloma.

Язык: Английский

Процитировано

2

Liquid biopsy technologies: innovations and future directions in breast cancer biomarker detection DOI

L. Cao,

Qiaohong Duan,

Zixin Zhu

и другие.

Biomedical Microdevices, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 24, 2025

Язык: Английский

Процитировано

2

Recent Advances in the Isolation Strategies of Plant-Derived Exosomes and Their Therapeutic Applications DOI Creative Commons

Jeong‐Geon Mun,

Dandan Song, Ji‐Ye Kee

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 144 - 144

Опубликована: Фев. 22, 2025

Exosome-like nanovesicles (ELNs) derived from natural products are gaining attention as innovative therapeutic agents due to their biocompatibility, low immunogenicity, and capability transport bioactive molecules such proteins, lipids, nucleic acids. These plant-derived ELNs exhibit structural similarities with mammalian exosomes, making them suitable for drug delivery, microbiome-targeted therapies, regenerative medicine. Recent studies highlight potential in treating cancer, inflammation, metabolic disorders. Additionally, have applications cosmetics, agriculture, the food industry. This review combines latest advancements research on ELNs, focusing isolation techniques, pharmacological effects, applications. Although offer promising opportunities, several challenges must be addressed, including standardization, large-scale production, vivo efficacy. By summarizing cutting-edge suggesting future directions, we aim inspire further development of next-generation platforms.

Язык: Английский

Процитировано

2

Exosome isolation and characterization for advanced diagnostic and therapeutic applications DOI Creative Commons
Nobendu Mukerjee, Arghya Bhattacharya, Swastika Maitra

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101613 - 101613

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

2

Exosomes in Precision Oncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics DOI Open Access

Emile M. Youssef,

Dannelle Palmer,

Brandon Fletcher

и другие.

Cancers, Год журнала: 2025, Номер 17(6), С. 940 - 940

Опубликована: Март 10, 2025

Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.

Язык: Английский

Процитировано

2

Use of Exosomes for Cosmetics Applications DOI Creative Commons
Luis Jesús Villarreal-Gómez,

Sergio Origel-Lucio,

Daniela Alejandra Hernández-Hernández

и другие.

Cosmetics, Год журнала: 2025, Номер 12(1), С. 9 - 9

Опубликована: Янв. 13, 2025

This study addresses a significant gap in the clinical validation and standardization of exosome-based applications within domains cosmetics regenerative medicine. Despite offering thorough overview potential therapeutic benefits underlying mechanisms exosomes, manuscript underscores several unresolved challenges, including paucity evidence, regulatory barriers, inconsistencies standardization, incomplete mechanistic understanding. The primary aim this research is to conduct systematic comprehensive review existing studies on exosomes skincare. To achieve this, literature was performed, drawing major medical database PubMed. approach facilitated collection meta-analysis relevant data, ensuring rigorous assessment recent advancements exosome research. main outcomes highlight multifaceted roles promoting skin rejuvenation mitigating signs aging. Specific discussed include pigmentation correction, wound healing, tissue repair, innovative delivery mechanisms. Moreover, examines emerging plastic surgery Challenges limitations, such as constraints, hurdles, need for further validation, are critically analyzed, providing framework future directions.

Язык: Английский

Процитировано

1