Alu Polymorphisms of Autophagy and Apoptosis Regulatory Genes as Human Lifespan Factors

Russian Journal of Genetics, Год журнала: 2025, Номер 61(1), С. 98 - 107

Опубликована: Янв. 1, 2025

Язык: Английский

Evolution of Repetitive Elements, Their Roles in Homeostasis and Human Disease, and Potential Therapeutic Applications

Biomolecules, Год журнала: 2024, Номер 14(10), С. 1250 - 1250

Опубликована: Окт. 2, 2024

Repeating sequences of DNA, or repetitive elements (REs), are common features across both prokaryotic and eukaryotic genomes. Unlike many their protein-coding counterparts, the functions REs in host cells remained largely unknown have often been overlooked. While there is still more to learn about functions, now recognized play significant roles beneficial pathological processes hosts at cellular organismal levels. Therefore, this review, we discuss various types review what known evolution. In addition, aim classify general mechanisms by which promote that variously harmful cells/organisms. Finally, address emerging role cancer, aging, neurological disorders provide insights into how RE modulation could new therapeutic benefits for these specific conditions.

Язык: Английский

Retrotransposon SINEs in Age-Related Diseases: Mechanisms and Therapeutic Implications

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102539 - 102539

Опубликована: Окт. 11, 2024

Язык: Английский