Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Язык: Английский
Exploring extracellular RNA as drivers of chemotherapy resistance in cancer
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Янв. 21, 2025
Язык: Английский
Mechanical Stress in GelMA/Fibrin Scaffolds Promotes Angiogenesis by Influencing Fibroblast-Derived Exosome Secretion
Materials Today Communications,
Год журнала:
2025,
Номер
unknown, С. 111892 - 111892
Опубликована: Фев. 1, 2025
Язык: Английский
Effect of conditioned medium from miRNA-34a transfected gastric cancer-associated fibroblast on peripheral blood mononuclear cells
BMC Immunology,
Год журнала:
2025,
Номер
26(1)
Опубликована: Фев. 25, 2025
Cancer-associated
fibroblast
(CAF)
cells
play
an
important
role
in
gastric
malignancy.
MiRNA
dysregulation
has
been
detected
CAF
cells,
which
is
related
to
the
tumor
progression
ability
of
these
cells.
Therefore,
this
study
aimed
evaluate
function
miRNA34a
carcinoma.
We
transiently
transfected
miRNA-34a
mimic
and
examined
effect
overexpressed
miRNA
on
PD-L1
expression
using
real-time
PCR.
Next,
we
evaluated
CAF-conditioned
medium
(CM)
immune
response
viability
cancer
cell
lines.
have
shown
that
significantly
reduced
(p
<
0.05).
However,
conditioned
had
no
significant
response.
also
found
CM
suppressed
line
relative
control
group
(P
indicated
can
reduce
proliferation.
Additionally,
may
improve
via
reduction.
Thus,
could
be
a
potential
therapeutic
agent
treatment.
Not
applicable.
Язык: Английский
Nano-drug delivery strategies affecting cancer-associated fibroblasts to reduce tumor metastasis
Acta Pharmaceutica Sinica B,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Spatial and single‐cell transcriptomic analysis reveals fibroblasts dependent immune environment in colorectal cancer
BioFactors,
Год журнала:
2025,
Номер
51(2)
Опубликована: Март 1, 2025
Abstract
Colorectal
cancer
(CRC)
exhibits
a
complex
tumor
microenvironment
with
significant
cellular
heterogeneity,
particularly
involving
cancer‐associated
fibroblasts
that
influence
behavior
and
metastasis.
This
study
integrated
single‐cell
RNA
sequencing
spatial
transcriptomics
to
dissect
fibroblast
heterogeneity
in
CRC.
Data
processing
employed
Seurat
for
quality
control,
principal
component
analysis
dimensionality
reduction,
t‐Distributed
Stochastic
Neighbor
Embedding
visualization.
Differentially
expressed
genes
were
identified
using
DESeq2.
Immune
infiltration
was
assessed
via
Single‐Sample
Gene
Set
Enrichment
Analysis,
CIBERSORT,
xCell
algorithms.
Prognostic
through
univariate
Cox
regression,
followed
by
consensus
clustering
survival
analysis.
Metabolic
pathways
explored
scMetabolism.
Experimental
validation
involved
CCK8,
scratch,
Transwell
assays
evaluate
the
roles
of
key
BGN
CERCAM
CRC
cell
proliferation
Machine
learning‐driven
four
fibroblast‐associated
(TRIP6,
TIMP1,
BGN,
CERCAM)
demonstrating
prognostic
relevance
Consensus
based
on
these
biomarkers
stratified
patients
into
three
distinct
molecular
subtypes
(Clusters
A–C).
Notably,
Cluster
C
exhibited
most
unfavorable
clinical
outcomes
coupled
marked
upregulation
all
fibroblast‐related
genes.
Comprehensive
immune
profiling
revealed
paradoxical
features
C:
heightened
global
activation
(characterized
substantial
leukocyte
infiltration)
coexisted
specific
immunosuppressive
elements,
including
enrichment
pro‐tumorigenic
M0
macrophages,
depletion
anti‐tumor
plasma
cells,
resting
memory
CD4+
T
along
coordinated
multiple
checkpoint
molecules.
Computational
prediction
TIDE
platform
suggested
enhanced
immunotherapy
responsiveness
patients.
Functional
demonstrated
knockdown
or
significantly
impaired
malignant
phenotypes,
reducing
proliferative
capacity,
migration
potential,
invasive
ability.
Fibroblasts
demonstrate
within
microenvironment,
impacting
prognosis
therapeutic
responses.
Key
emerge
as
potential
immunotherapeutic
targets,
offering
new
strategies
precision
treatment
Язык: Английский
Role of Cancer Associated Fibroblast (CAF) derived miRNAs on head and neck malignancies microenvironment: a systematic review
Parsa Golestannejad,
Mohamadparsa Monkaresi,
Farahnaz Zhian Zargaran
и другие.
BMC Cancer,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 1, 2025
MicroRNAs
(miRNAs)
play
a
key
role
in
regulating
gene
expression
within
the
tumor
microenvironment,
influencing
cancer
progression
and
therapy
response.
Cancer-associated
fibroblasts
(CAFs)
contribute
to
development
by
secreting
exosomal
miRNAs
that
promote
proliferation,
invasion,
resistance.
This
systematic
review
evaluates
impact
of
CAF-derived
on
head
neck
malignancies.
A
search
was
conducted
PubMed,
Scopus,
WOS,
Google
Scholar
following
PRISMA
guidelines.
Studies
focusing
cancers
were
included.
Data
extraction
covered
study
characteristics,
miRNA
profiling
methods,
functional
roles,
clinical
significance.
The
Scirap
tool
used
for
quality
assessment.
Among
921
identified
articles,
21
met
inclusion
criteria.
Findings
indicate
miR-21-5p,
miR-106-5p,
miR-196a
drive
oral
squamous
cell
carcinoma
(OSCC),
while
miR-124
miR-34a-5p
act
as
suppressors.
In
esophageal
(ESCC),
miR-21
miR-27a/b
chemotherapy
resistance,
whereas
miR-100-5p
inhibits
lymphangiogenesis.
(HNSCC),
miR-196b
may
serve
diagnostic
biomarkers.
Exosomal
miR-106a-5p
promotes
nasopharyngeal
(NPC)
metastasis,
miR-7
resistance
(HNC).
significantly
influence
progression,
These
findings
highlight
their
potential
biomarkers
therapeutic
targets,
warranting
further
research
personalized
treatment
strategies.
Язык: Английский
Prognostic value and anti-tumor immunity role of TMED9 in pan-cancer: a bioinformatics study
Translational Cancer Research,
Год журнала:
2024,
Номер
13(10), С. 5429 - 5445
Опубликована: Сен. 23, 2024
Transmembrane
p24
trafficking
protein
9
(
Язык: Английский
The spatial distribution of intermediate fibroblasts and myeloid-derived cells dictate lymph node metastasis dynamics in oral cancer
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 13, 2024
Oral
cancer
poses
a
significant
health
challenge
due
to
limited
treatment
protocols
and
therapeutic
targets.
We
aimed
investigate
the
invasive
margins
of
gingivo-buccal
oral
squamous
cell
carcinoma
(GB-OSCC)
tumors
in
terms
localization
genes
types
within
at
various
distances
that
could
lead
nodal
metastasis.
collected
tumor
tissues
from
23
resected
GB-OSCC
samples
for
gene
expression
profiling
using
digital
spatial
transcriptomics.
monitored
differential
varying
between
its
microenvironvent
(TME),
performed
deconvulation
study
immunohistochemistry
identify
cells
regulating
TME.
found
tumor–stromal
interface
(a
distance
up
200
µm
immune
cells)
is
most
active
region
disease
progression
GB-OSCC.
The
differentially
expressed
apex
genes,
such
as
FN1
COL5A1,
were
located
stromal
ends
margins,
together
with
enrichment
extracellular
matrix
(ECM)
an
immune-suppressed
microenvironment,
associated
lymph
node
Intermediate
fibroblasts,
myocytes,
neutrophils
enriched
ends,
while
cancer-associated
fibroblasts
(CAFs)
ends.
intermediate
transformed
into
CAFs
relocated
adjacent
where
they
participated
FN1-mediated
ECM
modulation.
have
generated
functional
organization
identified
spatially
contribute
metastasis
progression.
Our
dataset
might
now
be
mined
discover
suitable
molecular
targets
cancer.
Язык: Английский