Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown
Опубликована: Окт. 3, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155575 - 155575
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
8
Free Radical Biology and Medicine, Год журнала: 2024, Номер 225, С. 933 - 939
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
5
Journal of Medicinal Food, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
This study investigates the protective effects of CGK012 [(7S)-(+)-cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester], a small-molecule inhibitor targeting Wnt/β-catenin signaling pathway, against inflammatory responses elicited by lipopolysaccharide (LPS). The evaluated influence on heme oxygenase (HO)-1, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expressions in LPS-stimulated human endothelial cells. It examined its iNOS, tumor necrosis factor (TNF)-α, interleukin (IL)-1β LPS-challenged mice. treatment resulted increased HO-1 production, inhibited nuclear factor-kappa B activation, decreased levels COX-2/PGE2 iNOS/NO. Additionally, reduced signal transducer activator transcription-1 phosphorylation facilitated Nrf2 translocation binding to antioxidant response elements, culminating IL-1β production LPS-exposed umbilical vein Notably, inhibitory effect iNOS/NO was reversed upon knockdown via RNA interference. In vivo, markedly attenuated iNOS expression lung tissue TNF-α bronchoalveolar lavage fluid. These findings underscore anti-inflammatory potential CGK012, suggesting therapeutic promise for conditions characterized pathological inflammation.
Язык: Английский
Процитировано
0
BMC Nephrology, Год журнала: 2025, Номер 26(1)
Опубликована: Март 3, 2025
Chronic kidney disease (CKD) has been a growing public medical concern in recent years which calls for effective interventions. Mesenchymal stem cells (MSCs) have garnered increased interest past decades due to their potential repair and regenerate damaged tissues. Many clinical trials highlighted the safety effectiveness of with this novel cell therapy. MSC infusion can improve renal function indices such as glomerular filtration rate, urine protein, serum creatinine, blood urea nitrogen, while inhibiting immune response by increasing regulatory T cells. The therapeutic mechanisms may be primarily attributed combined immunomodulation, anti-inflammation, anti-fibrosis, promoting angiogenesis, anti-oxidation, anti-apoptosis, or tissue healing produced secretsome. However, CKD is broad concept many pathological etiologies including diabetes, hypertension, heart disease, immunological damage, family history failure, so on. Furthermore, efficacy MSCs influenced different sources, injection methods, medication dosage, homing proportion. As result, it timely essential access advancements application on CKD.
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Март 24, 2025
Studies examining the therapeutic potential of Mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) in wound healing and skin regeneration have progressed rapidly. Prior to considering clinical translation, a systematic comprehensive understanding these experimental details overall impact MSC-EVs on is necessary. 83 studies were identified Web Science, Embase, PubMed that satisfied set prespecified inclusion criteria. A random effects meta-analysis was conducted for closure rate, scar width, blood vessel density collagen deposition. Our findings demonstrate clear be developed as therapy both diabetic non-diabetic animal models. Moreover, subgroup analyses demonstrated apoptotic small (ApoSEVs) showed better efficacy than bodies (ApoBDs) (sEVs) outcome deposition, while sEVs displayed ApoEVs revascularization. Among frequently used routes administration, subcutaneous injection greater improvement closure, deposition revascularization compared dressing/covering. easier-access source MSCs, ADSCs best effect rate compared, BMMSCs Additionally, high heterogeneity observed collection conditions, separation methods, storage modifications, treatment dose, administration route, frequency underscores urgent need standardization areas, prior translation. PROSPERO CRD42024499172.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 156489 - 156489
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
2
Antioxidants, Год журнала: 2024, Номер 14(1), С. 17 - 17
Опубликована: Дек. 26, 2024
Spinal cord injury (SCI) initiates a cascade of secondary damage driven by oxidative stress, characterized the excessive production reactive oxygen species and other molecules, which exacerbate cellular tissue through activation deleterious signaling pathways. This review provides comprehensive critical evaluation recent advancements in antioxidant-based therapeutic strategies for SCI, including natural compounds, RNA-based therapies, stem cell interventions, biomaterial applications. It emphasizes limitations single-regimen approaches, particularly their limited efficacy suboptimal delivery to injured spinal tissue, while highlighting synergistic potential combination therapies that integrate multiple modalities address multifaceted pathophysiology SCI. By analyzing emerging trends current limitations, this identifies key challenges proposes future directions, refinement antioxidant systems, development multi-targeted overcome structural complexities cord. work underscores pressing need innovative integrative approaches advance clinical translation interventions improve outcomes SCI patients.
Язык: Английский
Процитировано
1
Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
0