Retinopathy in Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons
Myrsini Orfanidou, Stergios A. Pοlyzos

Medicina, Год журнала: 2024, Номер 61(1), С. 38 - 38

Опубликована: Дек. 30, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystemic disease, i.e., influencing various organ systems beyond the and, thus, contributing to comorbidities. Characterized by excessive fat accumulation in hepatocytes, MASLD frequently linked metabolic syndrome components, such as obesity, insulin resistance, dyslipidemia, and hypertension. Therefore, exploring intricate connection between other systems, including eyes, seems be essential. In this context, retinopathy has been investigated for its potential association with MASLD, since both conditions share common pathogenetic pathways. Chronic low-grade inflammation, oxidative stress, endothelial dysfunction are only some of those mechanisms progression possibly, determining bidirectional interplay retinal pathology. This narrative review aims summarize data concerning multisystemicity primarily focusing on eyes particularly, retinopathy. Identifying possible may emphasize need early screening integrated management approaches that address interconnected components within framework systemic disease. Further research necessary delineate precise develop targeted interventions mitigate impact aiming reduce overall burden improve patient outcomes.

Язык: Английский

Metabolic Dysfunction-Associated Steatotic Liver Disease and the Cardiovascular System DOI
Antonis A. Manolis, Theodora A. Manolis, Apostolos Vouliotis

и другие.

Trends in Cardiovascular Medicine, Год журнала: 2025, Номер 35(4), С. 258 - 265

Опубликована: Янв. 21, 2025

Язык: Английский

Процитировано

4
High-Intensity Interval Training Reduces Liver Enzyme Levels and Improves MASLD-Related Biomarkers in Overweight/Obese Girls DOI Open Access
Wissal Abassi, Nejmeddine Ouerghi, M. Hammami

и другие.

Nutrients, Год журнала: 2025, Номер 17(1), С. 164 - 164

Опубликована: Янв. 1, 2025

Background/Objectives: Despite the abundant body of evidence linking high-intensity interval training (HIIT) to cardiometabolic markers, little is known about how HIIT affects liver enzymes, particularly in obese adolescents. This study aimed investigate effects on metabolic dysfunction-associated steatotic disease (MASLD)-related biomarkers overweight/obese adolescent girls. Methods: Thirty-three girls (age, 17.0 ± 1.15 yr.; mass index, 33.3 4.77 kg/m2) were randomly assigned (n = 17) or control 16) groups. The group participated a nine-week program (three times weekly) without caloric restriction. Maximal aerobic speed, composition indexes, blood pressure, MASLD-related [liver enzymes (alanine aminotransferase (ALT) and aspartate (AST)), plasma lipids, uric acid, platelet count, homeostasis model assessment index for insulin-resistance (HOMA-IR)] examined at baseline after intervention. Results: Significant “time × group” interactions found systolic maximal ALT AST, glucose, HOMA-IR. resulted an increase speed (p 0.035) decrease lipids < 0.01), pressure 0.011), 0.013), AST 0.012), HOMA-IR but no significant changes acid count. None these markers changed group. Conclusions: improvement biomarkers. could be effective exercise therapy prevent reverse MASLD adolescents with obesity.

Язык: Английский

Процитировано

2
MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women DOI Creative Commons
Ilaria Milani,

Marianna Chinucci,

Frida Leonetti

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 855 - 855

Опубликована: Апрель 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Язык: Английский

Процитировано

1
TJ0113 attenuates fibrosis in metabolic dysfunction-associated steatohepatitis by inducing mitophagy DOI
Chun-Lian Huang,

Shen Qi-En,

Xufeng Cen

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114678 - 114678

Опубликована: Апрель 18, 2025

Язык: Английский

Процитировано

1
Effects of Different Exercises Combined with Different Dietary Interventions on Body Composition: A Systematic Review and Network Meta-Analysis DOI Open Access
Yongchao Xie, Yu Gu, Zhen Li

и другие.

Nutrients, Год журнала: 2024, Номер 16(17), С. 3007 - 3007

Опубликована: Сен. 5, 2024

Background: Exercise and dietary interventions are essential for maintaining weight reducing fat accumulation. With the growing popularity of various strategies, evidence suggests that combining exercise with offers greater benefits than either approach alone. Consequently, this combined strategy has become a preferred method many individuals aiming to maintain health. Calorie restriction, 5/2 intermittent fasting, time-restricted feeding, ketogenic diet among most popular today. Aerobic exercise, resistance training, mixed widely practiced forms physical activity. Exploring best combinations these approaches determine which yields effective results is both meaningful valuable. Despite trend, comparative analysis effects different lacking. This study uses network meta-analysis evaluate impact on body composition compare their efficacy. Methods: We systematically reviewed literature from database inception through May 2024, searching PubMed, Web Science, Embase, Cochrane Library. The was registered in PROSPERO under title: “Effects Combined Different Dietary Interventions Body Composition: A Systematic Review Network Meta-Analysis” (identifier: CRD42024542184). Studies were meticulously selected based specific inclusion exclusion criteria (The included studies must be randomized controlled trials involving healthy adults aged 18 65 years. Articles rigorously screened according specified criteria.), risk bias assessed using tool. Data aggregated analyzed meta-analysis, intervention efficacy ranked by Surface Under Cumulative Ranking (SUCRA) curves. Results: 78 5219 participants, comparing four interventions: calorie restriction (CR+EX), eating (TRF+EX), fasting (5/2F+EX), (KD+EX) composition. Intervention ranking as follows: (1) Weight Reduction: CR+EX > KD+EX TRF+EX 5/2F+EX (Relative CR+EX, effect sizes 5/2F+EX, 2.94 (−3.64, 9.52); 2.37 (−0.40, 5.15); 1.80 (−1.75, 5.34)). (2) BMI: 1.95 (−0.49, 4.39); 2.20 (1.08, 3.32); 1.23 (−0.26, 2.71)). (3) Fat Percentage: 2.66 (−1.56, 6.89); 2.84 (0.56, 5.13); 3.14 (0.52, 5.75).). (4) Lean Mass Male: −1.60 (−6.98, 3.78); −2.76 (−7.93, 2.40)). (5) Female: TRF+EX, −0.52 (−2.58, 1.55); −1.83 (−4.71, 1.04); −2.46 (−5.69,0.76).). Conclusion: emerged percentage while lean mass. For women, proved optimal preserving muscle While effectively reduces weight, it comparatively less at decreasing Hence, considered suboptimal.

Язык: Английский

Процитировано

7
Nicotinamide Adenine Dinucleotide Phosphate Oxidases and Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons
Vittoria Cammisotto, Emanuele Valeriani, Pasquale Pignatelli

и другие.

Antioxidants, Год журнала: 2025, Номер 14(1), С. 83 - 83

Опубликована: Янв. 13, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by lipid accumulation in the due to an excess their supplies or impairment management. While some patients remain stable for years, a proportion of them progress up steatohepatitis (MASH). MASLD links with systemic pathways being associated metabolic and non-metabolic diseases. Although represents first hit MASLD, pathophysiology its development progression MASH remains not completely understood. Oxidative stress has received particular attention recent as most oxidative process occurs liver, which also target stress-induced damage. Growing evidence linked activity nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) increased production reactive oxygen species damage fibrosis. NOX acts both hepatocytes non-parenchymal hepatic cells, contributing hepatocyte lipotoxicity, impaired microcirculation, stellate, mesenchymal stem cells activation proliferation. This review aims summarize current knowledge on involvement MASLD-MASH transition, focusing role isoforms, suggest targeting therapeutic approach MASLD.

Язык: Английский

Процитировано

0
Enhanced accuracy and stability in automated intra-pancreatic fat deposition monitoring of type 2 diabetes mellitus using Dixon MRI and deep learning DOI Creative Commons
Zhongxian Pan,

Qiuyi Chen,

Haiwei Lin

и другие.

Abdominal Radiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

Процитировано

0
Metabolic dysfunction associated steatotic liver and kidney stones: what is going on? DOI

Owen P Cunneely,

Anne S. Roberts, Sonia Fargue

и другие.

Current Opinion in Nephrology & Hypertension, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Metabolic dysfunction associated steatotic liver disease (MASLD) is increasing throughout the world, affecting nearly one in three individuals. Kidney stone disease, which also increasing, with MASLD. Common risk factors for both, including obesity, diabetes, dyslipidemia, hypertension, and metabolic syndrome, are likely drivers of this association. We present here a review associations possible interconnections between these two common processes. Epidemiological studies discordant regarding impact sex on association MASLD incident risk. The nature kidney stones rarely taken into account.A favorable milieu uric acid formation may be created by lower urine pH resulting from defective ammonium production insulin resistance, MASLD.Endogenous oxalate synthesis, major factor calcium stones, increased via decline activity enzymes involved detoxification glyoxylate, immediate precursor oxalate. driving remain to elucidated. Potential mechanisms identified underlying include an increase both stones.

Язык: Английский

Процитировано

0
Efficacy of pemafibrate in metabolic dysfunction associated steatotic liver disease and metabolic dysfunction and alcohol associated steatotic liver disease with dyslipidemia: alanine aminotransferase reduction and predictive factors DOI Creative Commons
Takako Nomura, Masafumi Ono, Kiyoyuki Kobayashi

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Background: Although pemafibrate has shown promise in treating metabolic dysfunction associated steatotic liver disease (MASLD), reports on its effects and alcohol (MetALD) are limited. The aim of this study was to evaluate the efficacy pemafibrate both conditions complicated with dyslipidemia, focus alanine aminotransferase (ALT) reduction. Predictive factors for treatment response were also identified. Methods: This retrospective, single-center cohort included 96 patients MASLDand14 MetALD treated 24 weeks. Changes function tests, lipid profiles, body mass index analyzed. Factors predicting ALT reduction identified using correlation analysis multivariate regression. Patients categorized as responders or non-responders based changes at Results: After weeks, significant improvements observed tests profiles MASLD; similar benefits found MetALD. median rate -24.75%. Higher baseline aspartate (AST) gamma-glutamyl transferase (GGT) levels greater Baseline AST GGT above upper limit normal predictors Conclusions: Pemafibrate effectively improved MASLD by dyslipidemia. enzyme levels, particularly normal, treatment.

Язык: Английский

Процитировано

0
Liver fibrosis progression analyzed with AI predicts renal decline DOI Creative Commons
Dan‐Qin Sun, Jiaqi Shen,

Xiaofei Tong

и другие.

JHEP Reports, Год журнала: 2025, Номер 7(5), С. 101358 - 101358

Опубликована: Фев. 13, 2025

The relationship between biopsy-proven liver fibrosis progression and renal function decline in patients with metabolic dysfunction-associated steatotic disease (MASLD) has not been fully elucidated. We used an automated quantitative assessment (qFibrosis) technique to investigate the temporal changes regional fibrosis. This retrospective longitudinal study included 68 MASLD their paired formalin-fixed sections of biopsies. One hundred eighty-four parameters were quantified five different hepatic regions, including portal tract, peri-portal, zone 2, peri-central central vein qFibrosis continuous values calculated for all samples based on 10 using assessment. Liver (QLF+, n = 18) regression (QLF-, 23) was defined as at least a 20% relative change over 23-month follow-up. Renal assessed by estimated glomerular filtration rate (eGFR) changes. eGFR greater QLF+ group (106.53 ± 13.71 ml/min/1.73 m2 vs. 105.28 12.46 m2) than QLF- (110.87 14.58 114.18 14.81 m2). In addition, pericentral regions more strongly associated periportal, 2 tract regions. combined these construct prediction model, which better differentiated (a cut-off value index 0.52, p <0.001). A is significantly related MASLD. Regional may efficiently predict decline, thus highlighting importance assessing worsening shows that be provides new perspective understanding complex pathological processes. combination artificial intelligence digital pathology earlier precisely quantify fibrosis, identifying function. opens possibility early interventions, are essential improve patients' outcomes.

Язык: Английский

Процитировано

0