5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance DOI Creative Commons
Li Fang, Tingting Liu, Yi Dong

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 3, 2025

Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms. Among epigenetic factors, m5C RNA modification is emerging as key player drug resistance, similar to the well-known m6A modification. affects metabolism processes, including splicing, export, translation, and stability, thereby influencing efficacy. This review highlights critical roles modulating chemotherapy, targeted therapy, radiotherapy, immunotherapy. also discusses functions regulators, methyltransferases, demethylases, m5C-binding proteins, essential modulators landscape that contribute dynamic regulatory network. Targeting these components offers promising strategy overcome resistance. We highlight need for further research elucidate specific mechanisms by which contributes develop precise m5C-targeted therapies, presenting m5C-focused strategies potential novel anticancer treatments.

Язык: Английский

5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance DOI Creative Commons
Li Fang, Tingting Liu, Yi Dong

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 3, 2025

Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms. Among epigenetic factors, m5C RNA modification is emerging as key player drug resistance, similar to the well-known m6A modification. affects metabolism processes, including splicing, export, translation, and stability, thereby influencing efficacy. This review highlights critical roles modulating chemotherapy, targeted therapy, radiotherapy, immunotherapy. also discusses functions regulators, methyltransferases, demethylases, m5C-binding proteins, essential modulators landscape that contribute dynamic regulatory network. Targeting these components offers promising strategy overcome resistance. We highlight need for further research elucidate specific mechanisms by which contributes develop precise m5C-targeted therapies, presenting m5C-focused strategies potential novel anticancer treatments.

Язык: Английский

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