Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116712 - 116712
Опубликована: Дек. 1, 2024
Язык: Английский
Cancers, Год журнала: 2025, Номер 17(3), С. 342 - 342
Опубликована: Янв. 21, 2025
In solid tumors, tumor-associated macrophages (TAMs) are one of the most numerous populations and play an important role in processes tumor cell invasion, metastasis, angiogenesis. Therefore, TAMs considered promising diagnostic prognostic biomarkers many attempts have been made to influence these cells as part antitumor therapy. There several key principles action on ТАМs: inhibition monocyte/macrophage transition; destruction macrophages; reprogramming macrophage phenotypes (polarization M2 M1); stimulation phagocytic activity CAR-M Despite large number studies this area, date, there no adequate approaches using therapy based alterations TAM functioning that would show high efficacy when administered a mono-regimen for treatment malignant neoplasms. Studies devoted evaluation drugs acting characterized by small sample heterogeneity patient groups; addition, such studies, chemotherapy or immunotherapy is used, which significantly complicates effectiveness agent TAMs. review, we attempted systematize evidence malignancies lung cancer, breast colorectal cervical prostate gastric head neck squamous soft tissue sarcomas.
Язык: Английский
Процитировано
1
CA A Cancer Journal for Clinicians, Год журнала: 2025, Номер unknown
Опубликована: Март 9, 2025
Despite the advances in cancer prevention, early detection, and treatments, all of which have led to improved survival, globally, there is an increased incidence cancer-related deaths. Although each patient tumor wholly unique, tipping point incurable disease common across patients: dual capacity for cancers metastasize resist systemic treatment. The discovery genetic mutations epigenetic variation that emerges during progression highlights evolutionary ecology principles can be used understand how evolves a lethal phenotype. By applying such eco-evolutionary framework, authors reinterpret our understanding metastatic process as one ecologic invasion define paths evolving therapy resistance. With this understanding, draw from successful strategies optimized strategic interventions with goal altering trajectory cancer. Ultimately, studying, treating using provides opportunity improve lives patients
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 90 - 90
Опубликована: Янв. 31, 2025
Chimeric antigen receptor-T (CAR-T) cell therapy has demonstrated impressive efficacy in the treatment of blood cancers; however, its effectiveness against solid tumors been significantly limited. The differences arise from a range difficulties linked to tumors, including an unfriendly tumor microenvironment, variability within and barriers CAR-T infiltration longevity at location. Research shows that reasons for decreased cells treating are not well understood, highlighting ongoing need strategies address these challenges. Current frequently incorporate combinatorial therapies designed boost functionality enhance their capacity effectively target tumors. However, remain testing phase necessitate additional validation assess potential benefits. CAR-NK (natural killer), CAR-iNKT (invariant natural killer T), CAR-M (macrophage) emerging as promising Recent studies highlight construction optimization cells, emphasizing overcome unique challenges posed by such hypoxia metabolic barriers. This review focuses on CAR
Язык: Английский
Процитировано
0
Life Sciences, Год журнала: 2024, Номер 361, С. 123300 - 123300
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
2
Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116712 - 116712
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0